Abstract. Let X be a space of homogeneous type and let L be an injective, non-negative, selfadjoint operator on L 2 (X) such that the semigroup generated by −L fulfills Davies-Gaffney estimates of arbitrary order. We prove that the operator, acts as a bounded linear operator on the Hardy space H 1 L (X) associated with L whenever F is a bounded, sufficiently smooth function. Based on this result, together with interpolation, we establish Hörmander type spectral multiplier theorems on Lebesgue spaces for non-negative, self-adjoint operators satisfying generalized Gaussian estimates in which the required differentiability order is relaxed compared to all known spectral multiplier results.