KRASallelic imbalance drives tumour initiation yet suppresses metastasis in colorectal cancerin vivo
Arafath K. Najumudeen,
Sigrid K. Fey,
Laura M. Millett
et al.
Abstract:OncogenicKRASmutations are well-described functionally and are known to drive tumorigenesis. Recent reports describe a significant prevalence ofKRASallelic imbalances or gene dosage changes in human cancers, including loss of the wild-type allele inKRASmutant cancers. However, there is still much debate over the function of wild-typeKRASin tumour initiation, progression and therapeutic response. We have developed a genetically engineered mouse model which allows deletion of the wild-type copy ofKrasin the cont… Show more
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