Kigelia africana (Lam.) Benth leaf extract inhibits rat brain and liver mitochondrial membrane permeability transition pore opening

Hesperidin Protects Mitochondrial Permeability Transition Pore of Rat Liver from Toxicity of High-Glucose Concentration and Some Heavy Metals

“…CaCl2 triggered the opening of the pore in intact mitochondria, whereas spermine, a standard inhibitor, signi cantly reversed the opening. This was consistent with previously published research [13].…”

“…Aside from MMPT pore modulation (opening and closing), mitochondria moreover contribute meaningfully to the generation of free radicals in the cell due to concentrated oxidative processes that eventually result in the synthesis of ATP, making it the cell's livewire. The mitochondrial matrix typically produces oxidants able to induce peroxidation of mitochondrial lipids in the inner mitochondrial membrane, making the membrane more penetrable and permeable to hydrophilic ions and high molecular structures, thereby depolarizing this supramolecular structure ATP is hydrolyzed rather than synthesized by the mitochondrial ATPase [13]. Our ndings showed that hesperidin had a protective effect on mitochondrial lipid peroxidation.…”

“…6 (A & B) and Table 1 respectively. 9], liver and breast cancers [10,11], and prostate cancer [12,13].…”

“…With the exception of substrate-level phosphorylation in the course of glycolysis, the mitochondrial ATP synthase is the location of ATP synthesis in the cell [13]. There was a proposition that mitochondrial ATPase is a component of the MMPT pore [27].…”

“…Aluminum chloride can be dangerous to humans, especially when anhydrous. Aluminum chloride has been shown to induce a transition pore in the mitochondrial membrane of albino rat brain mitochondria [13]. Mercury (II) sulfate, also known as mercuric sulfate, is a chemical compound (HgSO4).…”