Kaempferia parviflora extract increases energy consumption through activation of <scp>BAT</scp> in mice

Yoshino, Satoshi; Kim, Minji; Awa, Riyo; Kuwahara, Hiroshige; Kano, Yuriko; Kawada, Teruo

doi:10.1002/fsn3.144

Cited by 43 publications

(36 citation statements)

References 20 publications

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“…As KP showed no notable effects on food intake, the observed anti-obesity effects may be attributable to increased EE. mice (20). We also confi rmed that intraduodenal administration of a KP extract increased sympathetic nerve activity in BAT of rats (unpublished observations).…”

supporting

confidence: 63%

“…An anti-obesity effect of dietary supplementation of KP was reported in obese type II diabetic mice (18,19) and also in mice fed on a high-fat diet (20). As KP showed no notable effects on food intake, the observed anti-obesity effects may be attributable to increased EE.…”

Section: Discussionmentioning

confidence: 94%

“…KP was demonstrated to have some benefi cial effects such as stomach-protecting, anti-oxidant, and anti-infl ammatory effects (15)(16)(17). Moreover, it has been reported that dietary supplementation of rhizome powder of KP suppressed body weight increase, body fat accumulation, and glucose intolerance in obese type II diabtetic mice (18)(19)(20), suggesting anti-obesity effects of KP. As KP showed no notable effects on food intake, the observed anti-obesity effects may be attributable to increased EE.…”

mentioning

confidence: 99%

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Kaempferia parviflora Extract Increases Whole-Body Energy Expenditure in Humans: Roles of Brown Adipose Tissue

Matsushita

Yoneshiro

Aita

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Summary Kaempferia parvifl ora extract (KP) has been reported to have a preventive effect on obesity in mice, probably by increasing energy expenditure (EE). The aims of the current study were to examine the acute effects of KP ingestion on whole-body EE in humans and to analyze its relation to the activity of brown adipose tissue (BAT), a site of non-shivering thermogenesis. After an oral ingestion of an ethanol extract of KP, EE increased signifi cantly, showing a maximal increase of 229Ϯ69 kJ/d at 60 min, while it did not change after placebo ingestion. To evaluate BAT activity, the subjects underwent fl uorodeoxyglucose-positron emission tomography, and divided into two groups with high-and low-BAT activities. A similar and greater response of EE to KP ingestion was observed in the high-BAT group (351Ϯ50 kJ/d at 60 min), but not in the low activity group. Placebo ingestion did not cause any signifi cant EE change in either group. These results indicate that a single oral ingestion of the KP extract can potentially increase whole-body EE probably through the activation of BAT in healthy men, and may be useful as an anti-obesity regimen.

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supporting

confidence: 63%

Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

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Kaempferia parviflora Extract Increases Whole-Body Energy Expenditure in Humans: Roles of Brown Adipose Tissue

Matsushita

Yoneshiro

Aita

et al. 2015

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…In the present study, ingestion of KPE did not result in a change in energy intake during the ingestion period, which suggests that the anti-obesity effects of KPE involve acceleration of energy expenditure rather than inhibition of energy intake. Indeed, we previously reported that KPE enhances energy expenditure in mice via activation of sympathetic nerve activity 23. Others reported that one intake of KPE increases whole-body energy expenditure in humans 24.…”

Section: Discussionmentioning

confidence: 92%

“…KP also reportedly exhibits beneficial activities, such as anticholinesterase,11 antiinflammatory,12–14 spasmolytic,15 gastric ulcer amelioration,16 antioxidative,17 and vasodilatory18 effects in addition to regulation of adipocyte differentiation 19,20. Dietary supplementation with KP extract (KPE) also reportedly suppresses body weight increases, body fat accumulation, and glucose intolerance in obese mice 21–23. Other reports suggest that oral intake of KPE increases energy expenditure and fat utilization 23–25.…”

Section: Introductionmentioning

confidence: 99%

Daily intake of Kaempferia parviflora extract decreases abdominal fat in overweight and preobese subjects: a randomized, double-blind, placebo-controlled clinical study

Yoshino¹,

Awa²,

Miyake³

et al. 2018

DMSO

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PurposeObesity is a serious problem, which is now a worldwide health problem. Kaempferia parviflora extract (KPE) exhibits anti-obesity effects in animals. However, as no clinical trials have evaluated the anti-obesity effects of KPE in humans, we examined the effects of KPE in reducing abdominal fat in overweight and preobese Japanese subjects.Materials and methodsA 12-week, single-center, randomized, double-blind, placebo-controlled clinical trial was conducted. Seventy-six subjects (males and females aged 20 to <65 years) with a body mass index ≥24 and <30 kg/m2 were randomly assigned into two groups. The subjects in each group ingested one capsule of placebo or active KPE (containing 150 mg of KPE) once daily for 12 weeks. The primary outcome was reduction in visceral fat area as determined by computed tomography scanning. The key secondary outcomes were reductions in subcutaneous fat area and total fat area. Subgroup analysis was also performed in healthy subjects without dyslipidemia, hypertension, or hyperglycemia. The safety of KPE ingestion was also evaluated.ResultsCompared with the placebo group, the active KPE group exhibited significant reduction in abdominal fat area (visceral, subcutaneous, and total fat) and triglyceride levels after 12 weeks. Subgroup analyses demonstrated a significant reduction in abdominal fat area and triglyceride levels in healthy subjects compared with the placebo group after 12 weeks. Neither group exhibited adverse events related to the test foods or clinically relevant abnormal changes in physical, biochemical, or hematologic parameters, or in urinalysis results and medical interview.ConclusionDaily ingestion of KPE safely reduces body fat, particularly abdominal fat, in Japanese overweight and preobese subjects.

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Xanthoangelol and 4‐hydroxyderrcin suppress obesity‐induced inflammatory responses

Goto

Ikutani

et al. 2016

Obesity

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Objective: Obesity-induced inflammation plays a pivotal role in the pathogenesis of insulin resistance and type 2 diabetes. Xanthoangelol (XA) and 4-hydroxyderrcin (4-HD), phytochemicals extracted from Angelica keiskei, have been reported to possess various biological properties. Whether XA and 4-HD alleviate obesity-induced inflammation and inflammation-induced adipocyte dysfunction was investigated. Methods: For the in vitro study, a co-culture system composed of macrophages and adipocytes and macrophages stimulated with conditioned medium derived from fully differentiated adipocytes was conducted. For the in vivo study, mice were fed a high-fat diet supplemented with XA for 14 weeks. Results: XA and 4-HD suppressed inflammatory factors in co-culture system. Moreover, treatment of RAW macrophages with XA and 4-HD moderated the suppression of uncoupling protein 1 promoter activity and gene expression in C3H10T1/2 adipocytes, which was induced by conditioned medium derived from LPS-stimulated RAW macrophages. Also, XA and 4-HD inhibited c-Jun N-terminal kinase phosphorylation, nuclear factor-jB, and activator protein 1, the last two being transcription activators in activated macrophages. Furthermore, in mice fed the high-fat diet, XA reduced inflammatory factors within the white adipose tissue. Conclusions: These results suggest that XA and 4-HD might be promising phytochemicals to suppress obesity-induced inflammation and inflammation-induced adipocyte dysfunction.

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Kaempferia parviflora extract increases energy consumption through activation of BAT in mice

Cited by 43 publications

References 20 publications

<i>Kaempferia parviflora</i> Extract Increases Whole-Body Energy Expenditure in Humans: Roles of Brown Adipose Tissue

<i>Kaempferia parviflora</i> Extract Increases Whole-Body Energy Expenditure in Humans: Roles of Brown Adipose Tissue

Daily intake of <em>Kaempferia parviflora</em> extract decreases abdominal fat in overweight and preobese subjects: a randomized, double-blind, placebo-controlled clinical study

Xanthoangelol and 4‐hydroxyderrcin suppress obesity‐induced inflammatory responses

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