J. Leonard Goldner Award 2008: Effect of Extracorporeal Shock Wave Therapy on Cultured Tenocytes

Abstract

Background: Little has been reported about the biologic effect of shock waves on human normal or pathologic tendon tissue. We hypothesized that inflammatory cytokine and MMP production would be down-regulated by shock wave stimulation. . IL-6 levels were higher in the diseased tenocytes as compared with normal tenocytes (44.10 ± 16.72 versus 0.21 ± 0.55 ng/ml, (p < 0.05). IL-1 levels in normal cells increased (2.24 ± 5.02 ng/ml to 9.31 ± 6.85 ng/ml) after shock wave treatment (p = 0.04). In diseased tenocytes, levels of MMP-1 (1.12 ± 0.23 to 0.75 ± 0.24 ng/ml; p = 0.04) and MMP-13 (1.43 ± 0.11 to 0.80 ± 0.15 ng/ml; p = 0.04) were significantly decreased after shock wave treatment. The IL-6 level in diseased tenocytes was decreased (44.10 ± 16.72 to 14.66 ±

Periodontal cytokines profile under orthodontic force and extracorporeal shock wave stimuli in a rat model

“…Several studies have reported that the application of ESWT on cells obtained from different tissues such as bone, tendon etc. caused a marked elevation in the expression of several cytokines . However, in this in‐vivo study, no statistically significant difference was found, on any of the study days, in the percentage of the periodontal area of both the positive and negative control groups that stained positively for any of the cytokines analyzed (except for TNF‐α), on both compression and tension sides.…”

Extracorporeal shock wave therapy improves short‐term limb use after canine tibial plateau leveling osteotomy

“…Reduction of inflammatory cytokines characteristic of the CrCL deficient stifle by ESWT may be responsible for improved limb use . An in vitro study of injured human tenocytes that were harvested and then treated with ESWT confirmed reduced levels of interleukin 6 and metalloproteinases 1, 2, and 13 after ESWT of tendon cells in culture . Alteration of these inflammatory mediators may have contributed to the improvement in lameness.…”

Non-insertional Achilles tendinopathy

“…82 Increased levels of tissue healing factors TGF- β 1 and IGF-I expression have been shown after ESWT in a rat tendinopathy model 83 and a significant decrease in some interleukins 84 and matrix metalloprotienases (MMPs) have been shown after shock-wave treatment on cultured tenocytes. 85 …”