<i>Incilius alvarius</i> Cell-Based Synthesis of 5-Methoxy-N,N-Dimethyltryptamine

Lerer, Leonard; Reynolds, Eric C.; Varia, Jeet; Blakolmer, Karin; Lerer, Bernard

doi:10.1089/psymed.2022.0001

Psychedelic Medicine

2023

DOI: 10.1089/psymed.2022.0001

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Incilius alvarius Cell-Based Synthesis of 5-Methoxy-N,N-Dimethyltryptamine

Leonard Lerer¹,

Eric C. Reynolds²,

Jeet Varia³

et al.

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2024

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“…Shen et al reviewed the metabolism, pharmacokinetics, drug interactions, and pharmacological actions of 5-MeO-DMT (Shen et al, 2010). 5-MeO-DMT can be synthesized by various methods, including an Incilius alvarius cellbased synthesis method (Lerer et al, 2023), and a microbial method (Friedberg et al, 2023). The mammalian brain endogenously synthesizes DMT (Dean et al, 2019), and likely also 5-MeO-DMT (Barker et al, 2012).…”

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confidence: 99%

5-MeO-DMT in the complete resolution of the consequences of chronic, severe sexual abuse in early childhood—a retrospective case study

Turkia

2024

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5-MeO-DMT is a psychedelic substance with a short duration of action and intensive effects. Its therapeutic efficacy and practicality may significantly surpass those of classical psychedelics such as ayahuasca and LSD. This retrospective ethnographic inquiry features a woman in her mid-thirties who witnessed her mother's violent suicide and its bloody aftermath at the age of three. Before and after that, her childhood was characterized by domestic violence and sexual abuse perpetrated by several members of her family and extended family. In her twenties and thirties, she dated a member of the local mafia with the intention of asking him to kill her father, who had been the main perpetrator of the sexual abuse and violence. This plan was eventually not carried out, but it reflected her deep bitterness and wrath. A process initiated in her early thirties involving four 5-MeO-DMT sessions and a few additional sessions with psilocybin and ayahuasca in the course of two years completely resolved her symptoms related to the abuses, to the extent that she could rebuild a functional relationship with her father and feel love and compassion towards him. This outcome, i.e., the complete reversal of her attitude and emotions towards her father, appeared highly unusual. For the last three years, the outcome had remained stable. The article also presents the perspective of a female facilitator of this treatment process. The article contributes to a better understanding of the use of 5-MeO-DMT in severe traumatization as well as exemplifies the possible positive contributions of actors who are not medical professionals in resolving deep collective traumatization in societies.

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confidence: 99%

5-MeO-DMT in the complete resolution of the consequences of chronic, severe sexual abuse in early childhood—a retrospective case study

Turkia

2024

Preprint

View full text Add to dashboard Cite

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Incilius alvarius Cell-Based Synthesis of 5-Methoxy-N,N-Dimethyltryptamine

Cited by 1 publication

References 18 publications

5-MeO-DMT in the complete resolution of the consequences of chronic, severe sexual abuse in early childhood—a retrospective case study

5-MeO-DMT in the complete resolution of the consequences of chronic, severe sexual abuse in early childhood—a retrospective case study

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