<i>In Vivo</i> Visualization of Senile‐Plaque‐Like Pathology in Alzheimer's Disease Patients by MR Microscopy on a 7T System

Nakada, Tsutomu; Matsuzawa, H; Igarashi, Hironaka; Fujii, Yukihiko; Kwee, Ingrid L.

doi:10.1111/j.1552-6569.2007.00179.x

Cited by 88 publications

(74 citation statements)

References 30 publications

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“…These features included hypointense foci and diffuse granular patterns of less distinct hypointense foci in the cerebral cortex [10]. Similar patterns have been described in studies of AD transgenic mice and postmortem human AD cases, and were attributed to the presence of amyloid plaques using histological confirmation [11][12][13][14][15][16][17][18][19]. It has been proposed that the visualization on MRI of plaques in humans and mice is based on the fact that these deposits colocalize with iron, which gives rise to magnetic susceptibility effects on T2*-weighted images over volumes that are much larger than the actual size of amyloid plaques [17,[19][20][21][22][23][24].…”

Section: Introductionsupporting

confidence: 61%

Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker

Rooden

Versluis

Liem

et al. 2013

Alzheimer's & Dementia

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Background: Postmortem studies have indicated the potential of high-field magnetic resonance imaging (MRI) to visualize amyloid depositions in the cerebral cortex. The aim of this study is to test this hypothesis in patients with Alzheimer's disease (AD). Methods: T2*-weighted MRI was performed in 16 AD patients and 15 control subjects. All magnetic resonance images were scored qualitatively by visual assessment, and quantitatively by measuring phase shifts in the cortical gray matter and hippocampus. Statistical analysis was performed to assess differences between groups.Results: Patients with AD demonstrated an increased phase shift in the cortex in the temporoparietal, frontal, and parietal regions (P , .005), and this was associated with individual Mini-Mental State Examination scores (r 5 20.54, P , .05). Conclusion: Increased cortical phase shift in AD patients demonstrated on 7-tesla T2*-weighted MRI is a potential new biomarker for AD, which may reflect amyloid pathology in the early stages.

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Section: Introductionsupporting

confidence: 61%

Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker

Rooden

Versluis

Liem

et al. 2013

Alzheimer's & Dementia

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“…MRI detection of plaques in humans will thus become a major topic of research in coming years. Using 7 Tesla MRI in human studies may allow in vivo detection of cortical amyloid deposition in the future, based on susceptibility related imaging [182] or direct visualization of amyloid plaques using intrinsic or extrinsic contrast agents. The validity of first findings and their relevance for early diagnosis will be explored in the coming years.…”

Section: Future Directions: Novel Methodsmentioning

confidence: 99%

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020

Hampel

Lista

Teipel

et al. 2014

Biochemical Pharmacology

102

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Recent advances in understanding the molecular mechanisms underlying various paths toward the pathogenesis of Alzheimer's disease (AD) has begun to provide new insight for interventions to modify disease progression. The evolving knowledge gained from multidisciplinary basic research has begun to identify new concepts for treatments and distinct classes of therapeutic targets; as well as putative disease-modifying compounds that are now being tested in clinical trials. There is a mounting consensus that such disease modifying compounds and/or interventions are more likely to be effectively administered as early as possible in the cascade of pathogenic processes preceding and underlying the clinical expression of AD. The budding sentiment is that "treatments" need to be applied before various molecular mechanisms converge into an irreversible pathway leading to morphological, metabolic and functional alterations that characterize the pathophysiology of AD. In light of this, biological indicators of pathophysiological mechanisms are desired to chart and detect AD throughout the asymptomatic early molecular stages into the prodromal and early dementia phase. A major conceptual development in the clinical AD research field was the recent proposal of new diagnostic criteria, which specifically incorporate the use of biomarkers as defining criteria for preclinical stages of AD. This paradigm shift in AD definition, conceptualization, operationalization, detection and diagnosis represents novel fundamental opportunities for the modification of interventional trial designs. This perspective summarizes not only present knowledge regarding biological markers but also unresolved questions on the status of surrogate indicators for detection of the disease in asymptomatic people and diagnosis of AD

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“…10). 22) º Fig. 10 Axial in vivo susceptibility-weighted microscopic images at levels of the midbrain (A) and third ventricle (B) on a 7 T magnetic resonance imaging system of a patient with pure germinoma.…”

Section: Microscopic Imagingmentioning

confidence: 99%

Diagnostic Neuroimaging by Magnetic Resonance Imaging: Update

Fujii

Nakada

2010

Neurol. Med. Chir.(Tokyo)

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Magnetic resonance (MR) imaging remains the most versatile technique in diagnostic imaging. In addition to conventional imaging sequences such as T 1 -weighted imaging, T 2 -weighted imaging, or fluid-attenuated inversion recovery imaging, various techniques specific for certain pathological conditions are being continuously introduced. Pulse sequences for various imaging contrasts are becoming mature, and studies on high (3 T), or even ultra-high (7 T) field systems are emerging as a golden standard for neurosurgical practices. MR spectroscopic imaging capable of providing a pictorial display of the chemical properties of the brain and microscopic imaging providing images with significantly high anatomical resolution equivalent to histological preparations are now becoming essential for presurgical evaluation.

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In Vivo Visualization of Senile‐Plaque‐Like Pathology in Alzheimer's Disease Patients by MR Microscopy on a 7T System

Cited by 88 publications

References 30 publications

Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker

Cortical phase changes in Alzheimer's disease at 7T MRI: A novel imaging marker

Perspective on future role of biological markers in clinical therapy trials of Alzheimer's disease: A long-range point of view beyond 2020

Diagnostic Neuroimaging by Magnetic Resonance Imaging: Update

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