In vivo visualization of hyaluronic acid injection by high spatial resolution T2 parametric magnetic resonance images

Gensanne, D.; Josse, Gwendal; Schmitt, Anne-Marie; Lagarde, Jean‐Michel; Vincensini, D.

doi:10.1111/j.1600-0846.2007.00241.x

Cited by 30 publications

(31 citation statements)

References 16 publications

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“…The capability of MRI to obtain quantitative information allows in vivo monitoring of morphologic, functional and metabolic phenomena [34]. Using fat-saturated T2 the distribution of injectable fillers can be recognized [35], and intravenous administration of contrast material allows additional assessment of tissue perfusion. We used a dedicated imaging protocol for the improved detection of HA and the volumetry procedure had been validated on a specifically designed phantom.…”

Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

et al. 2015

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Objective: This prospective observational study evaluated magnetic resonance imaging (MRI) findings of hyaluronic acid (HA) injections used for the correction of HIV-associated facial lipoatrophy. Methods: Ten consecutive males underwent subdermal HA injection (mean 1.3 ± 0.6 ml per side) and MRI examinations prior to and then 1, 6 and 12 months after injection. Two radiologists blinded to the clinical data assessed morphologic and quantitative changes. Results: MRI revealed HA deposition in the subdermal and deep fat compartments. A significant HA volume increase was observed 1 month after injection (mean increase 331%, p < 0.0001) as compared to the injected amount. No volume reduction occurred at 12 months (p = 0.9961). The measured bound water content did not change (p > 0.9991), whereas skin thickness and tissue vascularization increased during the first 6 months (p = 0.01). Conclusion: Our data show that the cosmetic results of HA injections are caused by water binding in the deep facial fat and by a transient increase in vascularization and skin thickness.

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Section: Discussionmentioning

confidence: 99%

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

et al. 2015

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“…[17][18][19] The various brands have different concentrations of hyaluronic acid and cross-linking chemistries, which impart different viscosities. The more viscous forms of hyaluronic acid gel are appropriate for treating HIV lipoatrophy, while the soft and pliable consistency of the less viscous forms is particularly suitable for use in the lips, perioral, and periocular regions.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

“…In general, hyaluronic acid has a lower incidence of complications than semipermanent and permanent agents. 19 Furthermore, hyaluronic acid fillers can be rapidly reversed by injection of hyaluronidase.…”

Section: Hyaluronic Acidmentioning

confidence: 99%

Imaging Features of Midface Injectable Fillers and Associated Complications

Ginat

Schatz

2012

AJNR Am J Neuroradiol

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“…Exclusion criteria were: (1) any facial anti-wrinkle therapy; (2) facial soft tissue augmentation; (3) laser or chemical peeling; (4) cosmetic facial surgery below the level of the lower orbital rim within the previous 6 months; (5) pregnant or nursing women; (6) damaged skin, active skin diseases, or recently treated skin cancer close to the injection sites; (7) allergies; (8) autoimmune disease; (9) coagulation disorders; or (10) any other severe systemic disease.…”

Section: Subjectsmentioning

confidence: 99%

Clinical comparison between two hyaluronic acid-derived fillers in the treatment of nasolabial folds in Chinese subjects: BioHyalux versus Restylane

Sun

et al. 2016

Arch Dermatol Res

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Hyaluronic acid fillers are used to improve the appearance of nasolabial folds (NLF). This study aimed to compare the efficacy, safety, and durability of a new hyaluronic acid gel (BioHyalux) versus Restylane for the correction of NLF. This was a multicenter, double-blinded, randomized, controlled, non-inferiority clinical trial involving 88 subjects with moderate to severe NLF. Subjects were randomized to BioHyalux and Restylane on either sides of the NLF. NLF was assessed before and right after injection, and at 1 week, 1, 3, and 6 months. Patients were followed up for 13-15 months to evaluate the durability and long-term safety. A clinically meaningful response was predefined as at least one-point improvement on the Wrinkle Severity Rating Scale, which is a five-point scale. At 6 months, the response rate of BioHyalux was not inferior to that of Restylane (P < 0.05). At the 13-15 months follow-up, the response rate by investigators was 58.0 % on the BioHyalux side versus 63.8 % on the Restylane side. The response rate by subjects showed similar results, which was 56.5 % on the BioHyalux side versus 60.9 % on the Restylane side at 13-15 months. The subjects' Global Aesthetic Improvement Scale (GAIS) showed that most subjects felt improvements on both sides of NLF (P > 0.05) at all time points. At 6 months, 100 % reported improvements on both side; at 13-15 months, 60 % of subjects reported improvements with BioHyalux versus 64 % with Restylane. Adverse events were transient and predominantly mild or moderate in severity including injection site swelling, pain, itching, bruising, and tenderness. BioHyalux had reliable safety and tolerance, and could be an effective injectable filler for correcting NLF.

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In vivo visualization of hyaluronic acid injection by high spatial resolution T₂ parametric magnetic resonance images

Cited by 30 publications

References 16 publications

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

Hyaluronic Acid Filler in HIV-Associated Facial Lipoatrophy: Evaluation of Tissue Distribution and Morphology with MRI

Imaging Features of Midface Injectable Fillers and Associated Complications

Clinical comparison between two hyaluronic acid-derived fillers in the treatment of nasolabial folds in Chinese subjects: BioHyalux versus Restylane

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