<i>In vivo</i> tumor detection with combined MR–Photoacoustic-Thermoacoustic imaging

Huang, Lin; Cai, Wei; Zhao, Yuan; Wu, Dan; Wang, Lei; Wang, Yuqing; Lai, Dakun; Rong, Jian; Jiang, Huabei

doi:10.1142/s1793545816500152

Cited by 5 publications

(3 citation statements)

References 30 publications

(29 reference statements)

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“…Interestingly, the absorption properties of hemoglobin are affected by whether or not it binds to oxygen. By comparing the PA signals of deoxyhemoglobin (Hb), oxyhemoglobin (HbO) and oxygen saturation (sO 2 ) could be calculated in intratumoral and peritumoral areas ( Huang et al, 2016 ; Rich Laurie and Mukund, 2016 ; Dai et al, 2020 ; Jiao et al, 2020 ; Qian et al, 2020 ). In this way, OAI uses endogenous contrast mechanisms to visualize tumor microvascular structure and hemodynamics.…”

Section: Introductionmentioning

confidence: 99%

Noninvasive optoacoustic imaging of breast tumor microvasculature in response to radiotherapy

Xu²,

Xie³

et al. 2022

Front. Physiol.

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Detailed insight into the radiation-induced changes in tumor microvasculature is crucial to maximize the efficacy of radiotherapy against breast cancer. Recent advances in imaging have enabled precise targeting of solid lesions. However, intratumoral heterogeneity makes treatment planning and monitoring more challenging. Conventional imaging cannot provide high-resolution observation and longitudinal monitoring of large-scale microvascular in response to radiotherapy directly in deep tissues. Herein, we report on an emerging non-invasive imaging assessment method of morphological and functional tumor microvasculature responses with high spatio-temporal resolution by means of optoacoustic imaging (OAI). In vivo imaging of 4T1 breast tumor response to a conventional fractionated radiotherapy at varying dose (14 × 2 Gy and 3 × 8 Gy) has been performed after 2 weeks following treatment. Remarkably, optoacoustic images can generate richful contrast for the tumor microvascular architecture. Besides, the functional status of tumor microvasculature and tumor oxygenation levels were further estimated using OAI. The results revealed the differential (size-dependent) nature of vascular responses to radiation treatments at varying doses. The vessels exhibited an decrease in their density accompanied by a decline in the number of vascular segments following irradiation, compared to the control group. The measurements further revealed an increase of tumor oxygenation levels for 14 × 2 Gy and 3 × 8 Gy irradiations. Our results suggest that OAI could be used to assess the response to radiotherapy based on changes in the functional and morphological status of tumor microvasculature, which are closely linked to the intratumor microenvironment. OAI assessment of the tumor microenvironment such as oxygenation status has the potential to be applied to precise radiotherapy strategy.

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Section: Introductionmentioning

confidence: 99%

Noninvasive optoacoustic imaging of breast tumor microvasculature in response to radiotherapy

Xu²,

Xie³

et al. 2022

Front. Physiol.

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“…19,20 The actual averaged microwave power density at the surface of rat brain is below 0.32 mW/cm 2 , which is far below the safety standard (10 mW/cm 2 at 3 GHz). 21 …”

Section: Introductionmentioning

confidence: 99%

Thermoacoustic tomography of in vivo rat brain

Zhao

Chi

Huang

et al. 2017

J. Innov. Opt. Health Sci.

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We present for the¯rst time in vivo imaging of rat brain using microwave-induced thermoacoustic tomography (TAT). The in vivo imaging of rat brain was realized through an unconventional delivery of microwave energy from the front of rat brain (while the transducer was scanned along coronal plane of the animal brain), which maximized the microwave penetration into the brain. In addition, we found that the imaging contrast was highly dependent on the direction of the electric¯eld polarization (EFP) and that more tissue structures/compositions could be revealed when both X-and Y -EFPs were used for TAT. The in vivo TAT images of rat brain obtained were compared with the 3.0 T MRI images and histological photographs, and numerous important brain anatomical structures were identi¯ed. An example of our TAT approach for imaging a foreign object embedded in a rat brain was also demonstrated. This study suggests that TAT has a great potential to be used in neuroscience studies and in noninvasive imaging of brain disorders.

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“…With the publication of above reports, more and more researchers are aware of the advantages of TAI and put their e®orts into improving TAI system. Nowadays, the main TAI groups in this¯eld are Patch et al, [28][29][30][31][32][33] Ntziachristos et al, [34][35][36][37] Jiang et al, [38][39][40][41][42][43] Xin et al, [44][45][46][47][48][49] Arbabian et al, 50,51 Zheng et al, [52][53][54] Xing et al [80][81][82][83][84][85][86][87][88][89][90][91][92][93][94][95][96][97][98] and others. Under the e®orts of these researchers, the excitation source, data acquisition system and image algorithm have been improved greatly, and it can be revealed that TAI is e±cient in detecting the area with anomalous microwave absorption in biological tissue, particularly for breast cancer.…”

Section: Introductionmentioning

confidence: 99%

A review of microwave-induced thermoacoustic imaging: Excitation source, data acquisition system and biomedical applications

Cui

Yuan

2017

J. Innov. Opt. Health Sci.

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Microwave-induced thermoacoustic imaging (TAI) is a noninvasive modality based on the differences in microwave absorption of various biological tissues. TAI has been extensively researched in recent years, and several studies have revealed that TAI possesses advantages such as high resolution, high contrast, high imaging depth and fast imaging speed. In this paper, we reviewed the development of the TAI technique, its excitation source, data acquisition system and biomedical applications. It is believed that TAI has great potential applications in biomedical research and clinical study.

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In vivo tumor detection with combined MR–Photoacoustic-Thermoacoustic imaging

Cited by 5 publications

References 30 publications

Noninvasive optoacoustic imaging of breast tumor microvasculature in response to radiotherapy

Noninvasive optoacoustic imaging of breast tumor microvasculature in response to radiotherapy

Thermoacoustic tomography of in vivo rat brain

A review of microwave-induced thermoacoustic imaging: Excitation source, data acquisition system and biomedical applications

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