<i>In Vivo</i> Tracking of Superparamagnetic Iron Oxide-Labeled Bone Marrow Mesenchymal Stem Cells in Rat Skull Defects Repairing

Wang, Qiu-xu; Na, Zhenwen; Meng, Xue; Wei-Xian, Liu

doi:10.1166/jbt.2017.1601

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“…IONPs, as a NMR contrast agent, can be used for cell tracking by MRI. In a study, IONPs labeled BMSCs were implanted into skull defects of Sprague‐Dawley rats, the labeled cells were effectively tracked in vivo by MRI, and histological examination and statistical analysis indicated that IONPs labeling did not affect the viability or differentiation ability of BMSCs . IONPs‐based MSCs‐tracking was also attempted to implement in a sheep ovine model of tendonitis and the labeled cells remained detectable by MRI at 7 days .…”

Section: Ionps‐based Stem Cell Therapies For Bone Regenerationmentioning

confidence: 99%

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

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The paper provides a brief overview of the use of iron oxide nanoparticles (IONPs) in the areas of bone regenerative medicine. Reconstruction of bone defects caused by trauma, non-union, and bone tumor excision, still faces many challenges despite the intense investigations and advancement in bone-tissue engineering and bone regeneration over the past decades. IONPs have promising prospects in this field due to their controlled responsive characteristics in specific external magnetic fields and have been of great interest during the last few years. This Minireview aims to summarize the relevant progress and describes the following five aspects: (i) The general introduction of IONPs, with a focus on the magnetic properties as the base of application; (ii) using IONPs as tools to study and control stem cells for better treatment efficacy in stem-cell-based bone defect repair; (iii) the use of IONPs and their complexes in the delivery of therapeutic agents, including chemical drug molecules, growth factors, and genetic materials, to promote osteogenesis-related cell function and differentiation, healthy bone tissue growth, and functional reconstruction; (iv) magneto-mechanical actuation in the regulation of cells distribution, mechano-transduction membrane receptors activation, and mechanosensitive signaling pathways regulation, and (v) fabrication, characteristics, and in vitro and in vivo osteogenic effects of magnetic composite bone scaffolds. Ongoing prospects are also discussed.

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Section: Ionps‐based Stem Cell Therapies For Bone Regenerationmentioning

confidence: 99%

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

et al. 2018

ChemPhysChem

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In Vivo Tracking of Superparamagnetic Iron Oxide-Labeled Bone Marrow Mesenchymal Stem Cells in Rat Skull Defects Repairing

Cited by 1 publication

References 0 publications

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

Adaptive Materials Based on Iron Oxide Nanoparticles for Bone Regeneration

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