<i>In vivo</i>therapeutic exploring for<i>Mori folium</i>extract against type 2 diabetes mellitus in rats

Lyu, Kaibo; Wei, Yonggang; Ran, Junhua; Liu, Yunjuan; Zhu, Xueliang

doi:10.1042/bsr20210977

Cited by 6 publications

(4 citation statements)

References 22 publications

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“…Fufang Fanshiliu decoction (FFSLD) is a traditional Chinese medicine formula composed of 10 different herbal medicines and has been used for diabetes therapy for more than seven years in clinics. Associated research studies showed that the drugs in FFSLD, for instance, Psidium guajava L. (Fanshiliuye) [ 12 ], Morus alba L. (Sangye) [ 13 ], Euonymus alatus (Thunb.) Sied.…”

Section: Introductionmentioning

confidence: 99%

Fufang Fanshiliu Decoction Revealed the Antidiabetic Effect through Modulating Inflammatory Response and Gut Microbiota Composition

Huang

Chen³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Diabetes mellitus brings serious threats and financial burdens to human beings worldwide. Fufang Fanshiliu decoction (FFSLD), a traditional Chinese medicine formula showing great antidiabetic effects, has been used in clinics for many years. Objective. This study aims to explore the underlying therapeutic mechanisms of FFSLD in Type II diabetes mellitus (T2DM). Methods. Sprague–Dawley rats induced by high-fat diet feeding combined with streptozotocin injection were used to establish the T2DM model. All rats were randomly divided into 6 groups: control, model, metformin, high dosage, middle dosage, and low dosage of FFSLD. After 4 weeks of treatment, serum, intestinal mucosa, and fecal samples were collected for further analysis. ELISA was used to detect the diabetic-related serum indicators and proinflammation cytokines. Gene or protein expressions of mitogen-activated protein kinase (MAPK), interleukin 1 beta (IL-1β), transforming growth factor-beta (TGF-β), and tumor necrosis factor-alpha (TNF-α) in intestinal mucosa were analyzed by quantitative real-time polymerase chain reaction (RT-PCR) or western blot. 16s rRNA gene sequencing was used to detect the changes of gut microbiome in these groups. Intestinal gut microbiota (GM) composition was further analyzed according to the sequencing libraries. Results. FFSLD effectively recovered the diabetic-related biochemical indexes by reducing fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), insulin, and increasing high-density lipoprotein cholesterol (HDL-C). Furthermore, FFSLD significantly ameliorated the abnormal levels of proinflammation cytokines including IL-1β, IL-6, TNF-α, and TGF-β. In addition, the GM compositions of rats in control, model, and FFSLD treated groups were different. FFSLD significantly increased the relative abundance of Lactobacillus, Akkermansia, and Proteus, and reduced the relative abundance of Alistipes, Desulfovibrio, and Helicobacter. Moreover, these changed bacteria were closely related to the diabetic-related serum indicators and proinflammatory cytokines. Conclusion. These results suggest that FFSLD alleviates diabetic symptoms in T2DM rats through regulating GM composition and inhibiting inflammatory response, which clarify the therapeutic mechanism of FFSLD on T2DM and provide a theoretical basis for its further clinical application.

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Section: Introductionmentioning

confidence: 99%

Fufang Fanshiliu Decoction Revealed the Antidiabetic Effect through Modulating Inflammatory Response and Gut Microbiota Composition

Huang

Chen³

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…As expected, our study has confirmed that diabetes mellitus can induce visual fatigue, lens opacity and transparency reduction, and increased hepatic MDA concentrations in rats. Additionally, it decreased hepatic GSH concentrations and SOD, CAT, GSH, GR, and GSH-Px activities [27,28]. When the watersoluble, purified lutein beverage was administered to rats, visual fatigue was attenuated.…”

Section: Discussionmentioning

confidence: 98%

Lutein-Rich Beverage Alleviates Visual Fatigue in the Hyperglycemia Model of Sprague–Dawley Rats

Tang,

Wei,

et al. 2023

Metabolites

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Asthenopia is a syndrome based on the symptoms of eye discomfort that has become a chronic disease that interferes with and harms people’s physical and mental health. Lutein is an internationally recognized “eye nutrient”, and studies have shown that it can protect the retina and relieve visual fatigue. In this study, lutein was extracted from marigold (Tagetes erecta L.) and saponified. The purified lutein concentration measured by HPLC was 50.12 mg/100 g. Then, purified lutein was modified to be water-soluble by nanoscale modification and microencapsulation technology. Water-soluble lutein was then mixed with a leaching solution of Chinese wolfberry and chrysanthemum to make a functional beverage. The effects of this beverage on hepatic antioxidant enzymes and the alleviation of visual fatigue in a rat model of diabetes were investigated for 4 weeks. Lutein intake of 0.72 (medium-lutein beverage group) and 1.44 mg/mL (high-lutein beverage group) relieved visual fatigue, ameliorated turbidity symptoms of impaired crystalline lenses, reduced hepatic MDA concentration, increased hepatic GSH concentration, and significantly increased the activities of the hepatic antioxidant enzymes SOD, CAT, GSH-Px, and GR in rats. These data suggest that a lutein-rich beverage is an effective and harmless way to increase the total anti-oxidation capacity of lenses and alleviate visual fatigue.

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“…Rosmarinic acid, caffeic acid, rutin, and quercetin form PV increased serum-insulin, attenuation of α-amylase and α-glucosidase ( Raafat et al, 2016 ). Aqueous extract of MA improved glucose metabolism disorders, ameliorated the antioxidative ability, and decreased insulin resistance via IRS-1/PI3K/Glut-4 signaling pathway ( Cai et al, 2016 ; Lyu et al, 2021 ). Both MA extract ( Wu et al, 2017 ) and CI water extract ( Nepali et al, 2018 ) exert anti-diabetic activity by regulating the AMPK pathway in diet-induced obesity mice models.…”

Section: Biological Activitiesmentioning

confidence: 99%

Phytochemistry, Pharmacology and Quality Control of Xiasangju: A Traditional Chinese Medicine Formula

Luo

Zhong

et al. 2022

Front. Pharmacol.

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As a traditional Chinese herbal formula, Xiasangju (XSJ) is widely used in China for antipyresis and influenza treatment. However, XSJ still fails to have a comprehensive summary of the research progress in the last decade. This review summarizes the advanced research on the extraction process, phytochemistry, pharmacological activity, and quality control of XSJ. Current research mainly focuses on quality control and the pharmacological effects of single herbs and active ingredients, but many pharmacological mechanisms of the formula are unclear. The development of active ingredients reflects the active characteristics of triterpenes, phenolic acids and flavonoids, but the hepatotoxicity of Prunella vulgaris L. has not been taken into account. XSJ has extensive historical practical experiences, while systematic clinical trials remain lacking. Therefore, it is necessary to study the active ingredients and define the mechanisms of XSJ to develop multiple applications, and further studies on the dose range between its hepatoprotective activity and hepatotoxicity are necessary to improve the safety of the clinical application. In this review, the current problems are discussed to facilitate the reference basis for the subsequent research on the development of XSJ and future application directions.

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In vivotherapeutic exploring forMori foliumextract against type 2 diabetes mellitus in rats

Cited by 6 publications

References 22 publications

Fufang Fanshiliu Decoction Revealed the Antidiabetic Effect through Modulating Inflammatory Response and Gut Microbiota Composition

Fufang Fanshiliu Decoction Revealed the Antidiabetic Effect through Modulating Inflammatory Response and Gut Microbiota Composition

Lutein-Rich Beverage Alleviates Visual Fatigue in the Hyperglycemia Model of Sprague–Dawley Rats

Phytochemistry, Pharmacology and Quality Control of Xiasangju: A Traditional Chinese Medicine Formula

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