In vivostudy of the tissue distribution and immunosuppressive response of cyclosporin a-loaded polyester micro- and nanospheres

Application of PLGA nano/microparticle delivery systems for immunomodulation and prevention of allotransplant rejection

“…Nanoparticles and 1-µm microparticles demonstrated a greater response initially (0-24 h), whereas 30-µm microparticle led to more extensive immunosuppression on day 7. These studies demonstrated that PLGA micro/nanoparticles could be used as novel dosage forms, and could modulate the duration and intensity of immunosuppression, compared with free CyA, ultimately resulting in long term immunosuppressant therapy [56,60,61]. Targeted delivery and release of CsA-encapsulated PLGA nanoparticles (average diameter 260 nm) to both cells and lymphatics have been investigated in assays by Yoshikawa et al They observed that nanoparticles enable a depot release of CsA for 30 days and compared with free CsA, resulted in a greater local concentration of drug in the targeted tissues and cells.…”