<i>In vivo</i> Structure‐Activity Relationship of Dihydromethysticin in Reducing Nicotine‐Derived Nitrosamine Ketone (NNK)‐Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice

Xing, Chengguo; Hati, Santanu; Hu, Qi; Huo, Zhiguang; Lü, Junxuan

doi:10.1002/cmdc.202100727

Cited by 3 publications

(2 citation statements)

References 25 publications

(80 reference statements)

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“…The in vivo structure-activity relationship study found that the unnatural enantiomer of DHM was more potent than the natural enantiomer in NNK-induced A/J mice. More importantly, DHM analogues with high structural similarity show distinct efficacy in reducing NNK-induced DNA damage [ 61 ]. Moreover, it was determined that the methylenedioxy functional group in DHM that effectively reduced O 6 -mG adducts formation was critical to the chemopreventive activity and the lactone of DHM could be modified [ 61 , 62 ].…”

Section: Chemoprevention Of Lung Cancer By Dietary Phytochemicalsmentioning

confidence: 99%

“…More importantly, DHM analogues with high structural similarity show distinct efficacy in reducing NNK-induced DNA damage [ 61 ]. Moreover, it was determined that the methylenedioxy functional group in DHM that effectively reduced O 6 -mG adducts formation was critical to the chemopreventive activity and the lactone of DHM could be modified [ 61 , 62 ]. It was also found that DHM decreased the level of O 6 -mG in female C57BL/6 mice.…”

Section: Chemoprevention Of Lung Cancer By Dietary Phytochemicalsmentioning

confidence: 99%

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Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

et al. 2023

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Lung cancer is the second most common cancer in the world. Cigarette smoking is strongly connected with lung cancer. Benzo[a]pyrene (BaP) and 4-(N-methyl-N-nitrosamine)-1-(3-pyridyl)-butanone (NNK) are the main carcinogens in cigarette smoking. Evidence has supported the correlation between these two carcinogens and lung cancer. Epidemiology analysis suggests that lung cancer can be effectively prevented through daily diet adjustments. This review aims to summarize the studies published in the past 20 years exploring dietary phytochemicals using Google Scholar, PubMed, and Web of Science databases. Dietary phytochemicals mainly include medicinal plants, beverages, fruits, vegetables, spices, etc. Moreover, the perspectives on the challenges and future directions of dietary phytochemicals for lung cancer chemoprevention will be provided. Taken together, treatment based on the consumption of dietary phytochemicals for lung cancer chemoprevention will produce more positive outcomes in the future and offer the possibility of reducing cancer risk in society.

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Section: Chemoprevention Of Lung Cancer By Dietary Phytochemicalsmentioning

confidence: 99%

Section: Chemoprevention Of Lung Cancer By Dietary Phytochemicalsmentioning

confidence: 99%

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

et al. 2023

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A Novel Four‑Gene Biomarker for Tobacco Smoking-Induced Colorectal Cancer Progression

Jiang,

Zhang,

Huang

et al. 2024

Nicotine and Tobacco Research

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Introduction Cigarette smoking greatly promotes the progression and poor prognosis of colorectal cancer (CRC) patients, with the molecular mechanism still not fully clear. Methods In this study, CRC cells were exposed to tobacco specific nitrosamine 4‑(methylnitrosamino)‑1‑(3‑pyridyl) 1‑butanone (NNK), and the differentially expressed smoking-related genes were identified based on both NNK-induced CRC cells and a total of 763 CRC tissues from TCGA cohort. Cox regression analysis, ROC curve and Kaplan-Meier plot were used to establish the risk score model for CRC prognosis. Moreover, qRT-PCR, western blotting, colony formation, migration and invasion assays were performed to verify the core differentially expressed smoking-related gene and its molecular function in NNK-induced CRC progression. Results Results indicated NNK significantly enhanced CRC cell proliferation, migration and invasion. Moreover, a four-gene signature containing AKR1B10, CALB2, PLAC1, GNA15 was established as CRC prognosis marker. Among these four genes, AKR1B10 was further validated as the core gene, and its expression was significantly inhibited after NNK exposure in CRC cells. Results of gene enrichment analysis and western blotting suggested AKR1B10 might reduce the malignant progression of NNK-induced CRC cells through inhibiting Wnt signaling pathway by promoting E-Cadherin expression and inhibiting the expression of N-Cadherin, β-Catenin, Vimentin and Snail. Conclusion In conclusion, a new four smoking-related genes can be jointly used as prognostic markers for CRC. AKR1B10 served as a tumor suppressor, can be used as a potential target to inhibit NNK-induced CRC malignant progression through regulating Wnt signaling pathway. Implications This study demonstrates tobacco-derived NNK dependence would promote the malignant progression of colorectal cancer through regulating the expressions of AKR1B10/Wnt signaling pathway. And a novel four-gene signature is established for the prognosis prediction of smoking CRC patients. These findings have important translational implications given the continued use of tobacco and the difficulty in smoking cessation worldwide, which can be applied to alleviate the adverse effects induced by tobacco dependence on colorectal cancer patients.

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Opportunities and Challenges of Kava in Lung Cancer Prevention

Freeman

Mamallapalli

Bian

et al. 2023

IJMS

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Lung cancer is the leading cause of cancer-related deaths due to its high incidence, late diagnosis, and limited success in clinical treatment. Prevention therefore is critical to help improve lung cancer management. Although tobacco control and tobacco cessation are effective strategies for lung cancer prevention, the numbers of current and former smokers in the USA and globally are not expected to decrease significantly in the near future. Chemoprevention and interception are needed to help high-risk individuals reduce their lung cancer risk or delay lung cancer development. This article will review the epidemiological data, pre-clinical animal data, and limited clinical data that support the potential of kava in reducing human lung cancer risk via its holistic polypharmacological effects. To facilitate its future clinical translation, advanced knowledge is needed with respect to its mechanisms of action and the development of mechanism-based non-invasive biomarkers in addition to safety and efficacy in more clinically relevant animal models.

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In vivo Structure‐Activity Relationship of Dihydromethysticin in Reducing Nicotine‐Derived Nitrosamine Ketone (NNK)‐Induced Lung DNA Damage against Lung Carcinogenesis in A/J Mice

Cited by 3 publications

References 25 publications

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

Dietary Phytochemicals as Potential Chemopreventive Agents against Tobacco-Induced Lung Carcinogenesis

A Novel Four‑Gene Biomarker for Tobacco Smoking-Induced Colorectal Cancer Progression

Opportunities and Challenges of Kava in Lung Cancer Prevention

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