<i>In vivo</i> Skin Irritation Potential of a<i> Castanea sativa </i>(Chestnut) Leaf Extract, a Putative Natural Antioxidant for Topical Application

Almeida, Isabel F.; Valentão, Patrı́cia; Andrade, Paula B.; Seabra, Rosa M.; Pereira, Teresa M.; Amaral, Maria Helena; Costa, Pierre Mendes Da; Bahia, Maria Fernanda

doi:10.1111/j.1742-7843.2008.00301.x

Cited by 51 publications

(40 citation statements)

References 37 publications

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“…The content of phenolic compounds and the antioxidant activity are associated with beneficial health effects such as anticarcinogenic, anti-inflammatory, cardioprotective and neuroprotective activities [1,[3][4][5][6][7][8][9]. Phenolic acids (ellagic and gallic acid), flavonoids (rutin, quercetin and apigenin) and tannins were the main phenolic compounds reported [5,10].…”

Section: Introductionmentioning

confidence: 99%

Castanea sativa Bur: An Undervalued By-Product but a Promising Cosmetic Ingredient

et al. 2017

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Castanea sativa fruit processing generates high amounts of by-products, mostly bur. Currently, the cosmetic industry has a great interest in natural extracts as antioxidant sources. In the present study, C. sativa bur extract was used as the active ingredient, in different amounts, in topical hydrogels. The formulations were characterized regarding total phenolic and flavonoid contents (TPC and TFC, respectively), antioxidant activity (DPPH radical scavenging capacity and ferric reducing antioxidant power (FRAP)) and technological and microbiological properties. The same parameters were evaluated after 30 days of storage at 4 • C (T 30/4• C) and 20At time 0 (T 0 ), the TPC ranged between 0.79 and 9.65 mg of gallic acid equivalents (GAE)/g gel, while TFC varied from 0.05 to 1.23 mg of catechin equivalents (CAE)/g gel. Antioxidant activity was high for both assays, with values at T 0 ranging between 98.41 and 1013.43 µmol of ferrous sulphate equivalents (FSE)/g gel and varying between 431.96 and 990.84 µg of Trolox equivalents (TE)/g gel for FRAP and DPPH assays, respectively. No formulation exceeded the defined criteria in microbiological counts. All formulations showed similar technological profiles but particular attention should be given to pH. The gel with 50% of extract (F3) was selected as the best one for potential cosmetic applications.

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Section: Introductionmentioning

confidence: 99%

Castanea sativa Bur: An Undervalued By-Product but a Promising Cosmetic Ingredient

et al. 2017

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“…2 Induction of reactive oxygen species and free radicals above the physiological limits of the natural antioxidant defense mechanism in the skin lead to skin damage, including erythema, photoaging, and skin cancer. 3,4 Prolonged exposure to solar ultraviolet radiation activates biochemical reactions in human skin that cause depletion of cellular antioxidants and antioxidant enzyme producers, leading to a state of oxidative stress. Oxidative stress is a state of fragmented cellular DNA and membrane damage that can lead to death of cells and tissues due to protein denaturation and lipid peroxidation caused by reactive oxygen species and free radicals.…”

Section: Introductionmentioning

confidence: 99%

“…Novel photoprotective approaches are increasingly being used to prevent photodamage and to ameliorate sun-induced skin damage by prevention of penetration of ultraviolet radiation into the skin. [2][3][4] Topically applied antioxidants can directly enrich the natural antioxidant defense system and prevent/reduce oxidative damage to the skin. 7 Phyllanthus urinaria is a herbal plant belonging to the genus Phyllanthus, family Euphorbiaceae.…”

Section: Introductionmentioning

confidence: 99%

Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging

Mahdi¹,

Noor²,

Sakeena³

et al. 2011

IJN

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Background Recently there has been a remarkable surge of interest about natural products and their applications in the cosmetic industry. Topical delivery of antioxidants from natural sources is one of the approaches used to reverse signs of skin aging. The aim of this research was to develop a nanoemulsion cream for topical delivery of 30% ethanolic extract derived from local Phyllanthus urinaria ( P. urinaria ) for skin antiaging. Methods Palm kernel oil esters (PKOEs)-based nanoemulsions were loaded with P. urinaria extract using a spontaneous method and characterized with respect to particle size, zeta potential, and rheological properties. The release profile of the extract was evaluated using in vitro Franz diffusion cells from an artificial membrane and the antioxidant activity of the extract released was evaluated using the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) method. Results Formulation F12 consisted of wt/wt, 0.05% P. urinaria extract, 1% cetyl alcohol, 0.5% glyceryl monostearate, 12% PKOEs, and 27% Tween ® 80/Span ® 80 (9/1) with a hydrophilic lipophilic balance of 13.9, and a 59.5% phosphate buffer system at pH 7.4. Formulation F36 was comprised of 0.05% P. urinaria extract, 1% cetyl alcohol, 1% glyceryl monostearate, 14% PKOEs, 28% Tween ® 80/Span ® 80 (9/1) with a hydrophilic lipophilic balance of 13.9, and 56% phosphate buffer system at pH 7.4 with shear thinning and thixotropy. The droplet size of F12 and F36 was 30.74 nm and 35.71 nm, respectively, and their nanosizes were confirmed by transmission electron microscopy images. Thereafter, 51.30% and 51.02% of the loaded extract was released from F12 and F36 through an artificial cellulose membrane, scavenging 29.89% and 30.05% of DPPH radical activity, respectively. Conclusion The P. urinaria extract was successfully incorporated into a PKOEs-based nanoemulsion delivery system. In vitro release of the extract from the formulations showed DPPH radical scavenging activity. These formulations can neutralize reactive oxygen species and counteract oxidative injury induced by ultraviolet radiation and thereby ameliorate skin aging.

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“…Furthermore, plant extracts are also used in topical and cosmetic formulations such as fragrance, colorants, anti-irritant and antiaging etc [5]. Natural products may induce allergic and irritant contact dermatitis and phytophotodermatitis [6]. Topical treatments are a growing research area of formulators for skin diseases [7].…”

Section: Introductionmentioning

confidence: 99%

In vivo evaluation: the effects of a cream containing Acacia bark extract on skin melanin and erythema content

Ali¹,

Akhtar²,

Khan³

2012

pdia

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A b s t r a c t I In nt tr ro od du uc ct ti io on n: : Phenolic compounds have inhibitory effects on tyrosinase and inflammatory activities which lead to reduction in the melanin and erythema content. This is important for hyperpigmentation, dermatitis and other oxidative stress diseases. A Ai im m: : Investigation of the effects of a cream containing phenolic-rich extract of Acacia bark on the human skin melanin and erythema content. M Ma at te er ri ia al l a an nd d m me et th ho od ds s: : Eleven healthy male volunteers were analyzed and treated with active cream versus base for a period of three months by non-invasive bioengineering techniques. R Re es su ul lt ts s: : No serious adverse effects were observed after patch testing. Base showed insignificant results and active cream showed a significant decrease in skin melanin and erythema content after statistically applied ANOVA. C Co on nc cl lu us si io on ns s: : Our results show that the Acacia bark extract represents a valuable source of phenolic compounds produced naturally. Treatments of human skin with active cream containing phenolic-rich Acacia bark extract significantly reduce skin melanin and erythema in vivo and could be used for topical treatment of hyperpigmentation and dermatitis.K Ke ey y w wo or rd ds s: : Acacia nilotica, active cream, melanin, erythema.

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In vivo Skin Irritation Potential of a Castanea sativa (Chestnut) Leaf Extract, a Putative Natural Antioxidant for Topical Application

Cited by 51 publications

References 37 publications

Castanea sativa Bur: An Undervalued By-Product but a Promising Cosmetic Ingredient

Castanea sativa Bur: An Undervalued By-Product but a Promising Cosmetic Ingredient

Formulation and in vitro release evaluation of newly synthesized palm kernel oil esters-based nanoemulsion delivery system for 30% ethanolic dried extract derived from local Phyllanthus urinaria for skin antiaging

In vivo evaluation: the effects of a cream containing Acacia bark extract on skin melanin and erythema content

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