In vivo pharmacokinetic study of vanillic acid in monocrotaline‐induced pulmonary arterial hypertension rats and its tissue distribution
Xuxia A,
Meiduo Huayu,
Zhanqiang Li
et al.
Abstract:Vanillic acid (VA) is a bioactive chemical present in many food plants and fruits. It has been shown to have a protective effect on pulmonary tissues in monocrotaline‐induced pulmonary arterial hypertension, as well as an intervention effect on right ventricular remodeling. The purpose of this study was to develop and test a reliable method for assessing VA utilizing ultra‐performance liquid chromatography–high resolution mass spectrometry using caffeic acid as the internal standard. Across diverse substrates,… Show more
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