<i>In vivo</i>non-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes

Koo, Jasung; Jeon, Mansik; Oh, Yunok; Kang, Hyun Wook; Kim, Jeehyun; Kim, Chulhong; Oh, Junghwan

doi:10.1088/0031-9155/57/23/7853

Cited by 67 publications

(44 citation statements)

References 54 publications

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“…172,210,214 SWNT has a diameter of several nm and length of 50–300 nm and ICG was attached to the surface of the SWNT. Hence it is expected that the total particle size can remain relatively small, enabling tumor targeting by iv injection.…”

Section: Organic Compoundsmentioning

confidence: 99%

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

2014

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Photoacoustic tomography (PAT) can offer structural, functional and molecular contrasts at scalable observation level. By ultrasonically overcoming the strong optical scattering, this imaging technology can reach centimeters penetration depth while retaining high spatial resolution in biological tissue. Recent extensive research has been focused on developing new contrast agents to improve the imaging sensitivity, specificity and efficiency. These emerging materials have substantially accelerated PAT applications in signal sensing, functional imaging, biomarker labeling and therapy monitoring etc. Here, the potentials of different optical probes as PAT contrast agents were elucidated. We first describe the instrumental embodiments and the measured functional parameters, then focus on emerging contrast agent-based PAT applications, and finally discuss the challenges and prospects.

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Section: Organic Compoundsmentioning

confidence: 99%

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

2014

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“…Due to the relatively low sensitivity and poor spatial resolution of scintigraphy and single photon emission computed tomography, it is highly desirable to develop new imaging probes for other imaging modalities. The objective is to improve the detection of SLNs for either noninvasive visualization or intrasurgical guidance (10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

“…The limited tissue penetration of light is less critical because of the open field of view during surgery (16). For example, NIR fluorescence dyes, such as indocyanine green, have been investigated for sentinel node navigation during surgery either alone or in combination with nanoformulations (13,14). Owing to the nanometer-scale size, stability, and strong fluorescence, various nanoparticles and nanoformulations have been applied for SLN imaging and showed promising results in preclinical models (10)(11)(12).…”

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confidence: 99%

In vivo albumin labeling and lymphatic imaging

Wang

Lang

Huang

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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The ability to accurately and easily locate sentinel lymph nodes (LNs) with noninvasive imaging methods would assist in tumor staging and patient management. For this purpose, we developed a lymphatic imaging agent by mixing fluorine-18 aluminum fluoridelabeled NOTA (1,4,7-triazacyclononane-N,N',N''-triacetic acid)-conjugated truncated Evans blue ( 18 F-AlF-NEB) and Evans blue (EB) dye. After local injection, both 18 F-AlF-NEB and EB form complexes with endogenous albumin in the interstitial fluid and allow for visualizing the lymphatic system. Positron emission tomography (PET) and/or optical imaging of LNs was performed in three different animal models including a hind limb inflammation model, an orthotropic breast cancer model, and a metastatic breast cancer model. In all three models, the LNs can be distinguished clearly by the apparent blue color and strong fluorescence signal from EB as well as a high-intensity PET signal from 18 F-AlF-NEB. The lymphatic vessels between the LNs can also be optically visualized. The easy preparation, excellent PET and optical imaging quality, and biosafety suggest that this combination of 18 F-AlF-NEB and EB has great potential for clinical application to map sentinel LNs and provide intraoperative guidance.PET | lymph node | optical imaging | albumin | Evans blue

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“…When compared with blood in phantom studies, SWNTs show promising properties for the significant signal enhancement of for PA imaging at about 1064 nm wavelength. 290 Recently, noninvasive SWNT-enhanced PA imaging in a small animal model was applied in many biomedical applications, such as SLNs imaging, 271 cancer targeting. 290 293 The SLNs PA imaging were successfully imaged in vivo with intrinsic optical contrast at micrometer level of resolution.…”

Section: Photoacoustic Imagingmentioning

confidence: 99%

Nanoparticles for Molecular Imaging

Yang¹,

Liao²,

Thakor³

et al. 2014

j biomed nanotechnol

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Imaging techniques have been instrumental in the visualization of fundamental biological processes, identification and diagnosis of diseased states and the development of structure-function relationships at the cellular, tissue and anatomical levels. Together with the advancements made in imaging techniques, complementary chemical compounds, also known as imaging probes or contrast agents, are developed to improve the visibility of the image by enhancing sensitivity, and for the identification and quantitation of specific molecular species or structures. Extensive studies have been conducted to explore the use of inorganic nanoparticles which exhibit magnetic and optical properties unique to the nano regime so as to enhance the signals sensitivity for magnetic resonance and fluorescent imaging. These physical properties are tailored by controlling the size, shape and surface properties of nanoparticles. In addition, surface modification of nanoparticles is often required to improve its stability, compatibility and functionality. Surfactants, surface-active agents, have been used to engineer the surface characteristics of nanoparticles to improved particle stability and functionality. Surfactants enhance nanoparticle stability through the reduction of surface energy, and by acting as a barrier to agglomeration through either steric hindrance or repulsive electrostatic forces. Coupling of nanoparticles with biomolecules such as antibodies or tumor targeting peptides are enabled by the presence of functional groups (e.g., carboxyl or amine groups) on surfactants. This paper provides an overview of the chemistry underlying the synthesis and surface modification of nanomaterials together with a discussion on how the physical properties (e.g., magnetic, absorption and luminescent) can be controlled. The applications of these nanoparticles for magnetic resonance, fluorescent and photoacoustic imaging techniques that do not rely on ionizing radiation are also covered in this review.

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In vivonon-ionizing photoacoustic mapping of sentinel lymph nodes and bladders with ICG-enhanced carbon nanotubes

Cited by 67 publications

References 54 publications

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

Structural and functional photoacoustic molecular tomography aided by emerging contrast agents

In vivo albumin labeling and lymphatic imaging

Nanoparticles for Molecular Imaging

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