<i>In vivo</i> micro‐angiography by means of speckle‐variance optical coherence tomography (<scp>SV</scp>‐<scp>OCT</scp>) is able to detect microscopic vascular changes in naevus to melanoma transition

Carvalho, Nathalie De; Ciardo, Silvana; Cesinaro, A. M.; Jemec, Gregor B. E.; Ulrich, Martina; Welzel, Julia; Holmes, Jon; Pellacani, Giovanni

doi:10.1111/jdv.13311

Cited by 43 publications

(48 citation statements)

References 7 publications

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“…Very recently, first investigations have reported the applicability of D-OCT for the evaluation of vascular patterns in vivo including tumour angiogenesis 7 and functional blood vessel dilatation/ constriction. 8,10 In contrast to established techniques such as dermoscopy and reflectance confocal microscopy, D-OCT allows the analysis of microvasculature to a depth of at least 500 lm and the 3D reconstruction of vascular networks.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 As a recent technical improvement, 'dynamic' OCT (D-OCT) allows the visualization of blood flow in vivo and therefore enables the visualization of microvasculature. 2,[7][8][9][10] As in all imaging techniques, correct image acquisition is important in D-OCT, but as functional data of blood flow is produced, special attention to the acquisition process and the reproducibility of the findings is required. New technology often needs new terminology, which is of major importance for the description of findings, for interpretation of data and to extract information.…”

Section: Introductionmentioning

confidence: 99%

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Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

Ulrich¹,

Themstrup

Carvalho

et al. 2017

Acad Dermatol Venereol

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

Ulrich¹,

Themstrup

Carvalho

et al. 2017

Acad Dermatol Venereol

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“…[63] In dermatology, OCT has become a popular tool for evaluation of various skin disorders in the clinic[6465666768] and OCTA is used for exploring vascular skin lesions. [6970]…”

Section: Optical Coherence Tomography Angiography and Other Diseasesmentioning

confidence: 99%

Optical coherence tomography angiography: A new tool in glaucoma diagnostics and research

Daneshvar¹,

Nouri‐Mahdavi²

2017

J Ophthalmic Vis Res

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Optical coherence tomography angiography (OCTA) is a new modality in ocular imaging which provides high resolution view of the vascular structures in the retina and optic nerve head. This technology has the advantages of being noninvasive, rapid and reproducible. OCTA is becoming a valuable tool for evaluating many retinal and optic nerve diseases. This article provides a brief introduction to the technology and its application in the field of glaucoma diagnostics.

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“…The commercially available form, named Dynamic OCT (D‐OCT; a variation in speckle variance OCT), enables in vivo imaging of skin microvasculature and has been validated for imaging of cutaneous blood flow . Initial reports on the potential utility of D‐OCT for diagnosing different skin lesions, including skin cancer, have been published . This study explores D‐OCT's ability to differentiate specific BCC subtypes based on microvascular and structural imaging.…”

Section: Introductionmentioning

confidence: 99%

In vivo differentiation of common basal cell carcinoma subtypes by microvascular and structural imaging using dynamic optical coherence tomography

Themstrup

Carvalho

Nielsen

et al. 2018

Experimental Dermatology

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The subtype of basal cell carcinoma (BCC) influences the choice of treatment. Optical coherence tomography (OCT) is a non-invasive imaging tool, and a recent development of an angiographic version of OCT has extended the application of OCT to image the cutaneous microvasculature (so-called dynamic OCT, D-OCT). This study explores D-OCT's ability to differentiate the common BCC subtypes by microvascular and structural imaging. Eighty-one patients with 98 BCC lesions, consisting of three subtypes: 27 superficial BCC (sBCC), 55 nodular BCC (nBCC) and 16 infiltrative BCC (iBCC) were D-OCT scanned at three European dermatology centres. Blinded evaluations of microvascular and structural features were performed, followed by extensive statistical analysis of risk ratio (RR) and multiple correspondence analysis. nBCC lesions displayed most characteristic structural and vascular features. Serpiginous vessels, branching vessels, vessels creating a circumscribed figure and sharply demarcated hyporeflective ovoid structures in the dermis were all associated with a higher risk of the subtype being nBCC. The presence of highly present lines and dark peripheral borders at the margin of ovoid structures was negatively associated with iBCC. Lastly, the finding of hyporeflective ovoid structures protruding from epidermis correlated with sBCC. We identified various microvascular and structural D-OCT features that may aid non-invasive identification of BCC subtypes. This would allow clinicians to individualize and optimize BCC treatment as well as aid follow-up of non-surgical treatment.

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In vivo micro‐angiography by means of speckle‐variance optical coherence tomography (SV‐OCT) is able to detect microscopic vascular changes in naevus to melanoma transition

Cited by 43 publications

References 7 publications

Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

Dynamic optical coherence tomography of skin blood vessels – proposed terminology and practical guidelines

Optical coherence tomography angiography: A new tool in glaucoma diagnostics and research

In vivo differentiation of common basal cell carcinoma subtypes by microvascular and structural imaging using dynamic optical coherence tomography

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