2001
DOI: 10.1046/j.1365-2567.2001.01204.x
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In vivo maturation and migration of dendritic cells

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Cited by 98 publications
(73 citation statements)
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“…Central to pathways for activating tumor antigen-specific T cell and antibody responses is the uptake, processing, and presentation of the tumor antigen by dendritic cells (DC), professional antigen presenting cells [1,2]. The importance of endogenous DC has been highlighted by better clinical outcomes for patients with various tumor types when DC are found to be infiltrating the tumor [3,4].…”
Section: Introductionmentioning
confidence: 99%
“…Central to pathways for activating tumor antigen-specific T cell and antibody responses is the uptake, processing, and presentation of the tumor antigen by dendritic cells (DC), professional antigen presenting cells [1,2]. The importance of endogenous DC has been highlighted by better clinical outcomes for patients with various tumor types when DC are found to be infiltrating the tumor [3,4].…”
Section: Introductionmentioning
confidence: 99%
“…The latter interactions lead to transcriptional activation of genes encoding the co-stimulatory molecules (6). By the time the DCs migrate from the site of infection to the draining lymph nodes (DLN), they have matured, present antigenic peptides, and express costimulatory molecules (7,8). In the DLN, the mature DCs interact with naïve T cells through both TCR-peptide/ MHC and CD28-CD80/CD86 and activate T cells by providing two stimulating signals.…”
mentioning
confidence: 99%
“…The immature stage is able to capture antigens by several mechanisms such as macropinocytosis, phagocytosis, and receptor-mediated uptake, especially through lectin receptors such as Langerin͞CD207 (11) and DEC-205͞CD205 (12). Typically, these immature cells are located in nonlymphoid organs such as skin, trachea, intestine, vagina, etc., sites that are normally in contact with environmental antigens (13,14). In contrast, the mature stage is characterized by a high capacity for T cell stimulation and differentiation, and these cells are often located in secondary lymphoid organs (spleen, lymph nodes, and Peyer's patches).…”
mentioning
confidence: 99%
“…In contrast, the mature stage is characterized by a high capacity for T cell stimulation and differentiation, and these cells are often located in secondary lymphoid organs (spleen, lymph nodes, and Peyer's patches). In their immature stage, DCs express many receptors for antigen uptake as well as environmental sensing, e.g., Toll-like receptors, whereas in the more mature state, DCs express high levels of activation (CD25) (15) and costimulatory (CD40 and CD86) molecules important for T cell responses (14).…”
mentioning
confidence: 99%