<i>In vivo</i> investigations on the penetration of various oils and their influence on the skin barrier

Patzelt, Alexa; Lademann, Juergen; Richter, Heike; Darvin, Maxim E.; Schanzer, Sabine; Thiede, Gisela; Sterry, Wolfram; Vergou, Theognosia; Hauser, Matthias

doi:10.1111/j.1600-0846.2011.00578.x

Cited by 121 publications

(150 citation statements)

References 15 publications

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“…The skin hydration may improve the penetration of active substances [20] . Petroleum jelly is more effective occlusiver than oils [27] . Hydrophobic bases, especially Vaseline petroleum jelly, provide prolonged contact of the formulation with the skin as they tend to remain on the skin surface [21,27,28] .…”

Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 90%

“…Some hydrophobic components of a base may penetrate into the lipids of the stratum corneum intercellular cement and thus impact properties of skin barrier (stratum corneum permeability, values of skin/ semisolid formulation partition coefficients for active substances may be changed) but the rate of this process is usually limited [27] . For vegetable oils and liquid paraffin a deeper penetration than into the first 2-3 upper layers of the stratum corneum could be excluded when they are applied for 30 min at once [27] .…”

Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 99%

“…For vegetable oils and liquid paraffin a deeper penetration than into the first 2-3 upper layers of the stratum corneum could be excluded when they are applied for 30 min at once [27] . However, under the influence of the systematic application of the hydrophobic formulations, lipophilic components of a base may be incorporated into the lipids of the stratum corneum.…”

Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 99%

“…It can provide transepidermal water loss reduction and increase in the hydration state of the stratum corneum [21,27] . The skin hydration may improve the penetration of active substances [20] .…”

Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 99%

“…Vaseline petrolatum adheres strongly to the skin and thus its use provides prolonged contact of the formulation with the skin [27] . The effectiveness of petrolatum-based ointments as active substances carriers may also result from the occlusive properties of these bases.…”

Section: Comparative Release Of Active Substances From Hydrophobic Bamentioning

confidence: 99%

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Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Jankowski¹,

Dyja²,

Sarecka-Hujar³

2017

pharmaceutical-sciences

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Jankowski, et al.: Dermal and Transdermal Delivery from SemisolidsThe selection of a semisolid base type (hydrophobic, hydrophilic or emulsion) has an essential influence on the skin and transdermal delivery of active substances. The cutaneous and percutaneous absorption may be influenced by interactions occurring between base components and skin on the one hand and interactions between base components and the active ingredient on the other hand. The present article discusses the utility of different types of semisolid bases as carriers of active substances and summarizes results of studies comparing delivery of active substances from different semisolid bases.

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Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 90%

Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 99%

Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 99%

Section: Types Of Bases Used In Semisolid Formulations Hydrophobic Bamentioning

confidence: 99%

Section: Comparative Release Of Active Substances From Hydrophobic Bamentioning

confidence: 99%

See 3 more Smart Citations

Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Jankowski¹,

Dyja²,

Sarecka-Hujar³

2017

pharmaceutical-sciences

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Fixing the Skin Barrier: Past, Present and Future — Man and Dog Compared

Marsella¹

2013

Advances in Veterinary Dermatology

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Effectiveness of Protective Preparations: Impact of Vegetable Oil Additives to Recipes

Kulawik‐Pióro

Klimaszewska

Ogorzałek

et al. 2020

Euro J Lipid Sci & Tech

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The aim of the study is to demonstrate the effect of the addition of vegetable oils rich in EFA on the effectiveness of hydrophobic skin protection preparations intended for work in the wet environment. The research hypothesis assumes that the increase in the concentration of vegetable oils in the formula of protective preparations improves their spreadability on the skin, thus translating into acceptance of the preparations by users, improving their quality of life, strengthening the barrier functions of the skin without reducing the effectiveness of the protective action. The distribution capacity of pure vegetable oils is determined using instrumental analysis and sensory analysis. Also, TEWL tests are used to evaluate their occlusal properties. For protective preparations based on them, the distribution capacity is tested by in vitro methods as well as in vivo tests and sensory analyses are performed. The effectiveness of the tested preparations is measured by tests concerning absorbability, occlusion capacity and washability. The results are analyzed and compared, and a correlation matrix is developed to establish the relationship between sensory and instrumental measurements. The effectiveness of the preparations depends on the type of oil (its spreadability and viscosity) and the amount in the formulation. Practical Applications: For hydrophobic preparations of ointment type, there is a possibility to implement such instrumental techniques as: determination of preparation consistency by means of a cone, ability to distribute by means of parallel plates, but also determination of preparation viscosity by rheological methods. Viscosity, spreading ability, and oil occlusion ability are the most important parameters that should be taken into account when we design hydrophobic skin protection preparations intended for the works in the wet environment.

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In vivo investigations on the penetration of various oils and their influence on the skin barrier

Cited by 121 publications

References 15 publications

Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Dermal and Transdermal Delivery of Active Substances from Semisolid Bases

Fixing the Skin Barrier: Past, Present and Future — Man and Dog Compared

Effectiveness of Protective Preparations: Impact of Vegetable Oil Additives to Recipes

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