<i>In vivo</i>intra-operative breast tumor margin detection using a portable OCT system with a handheld surgical imaging probe

Erickson-Bhatt, Sarah J.; Nolan, Ryan M.; Shemonski, Nathan D.; Adie, Steven G.; Putney, Jeffrey; Darga, Donald; McCormick, Daniel T.; Cittadine, Andrew J.; Marjanović, Marina; Chaney, Eric J.; Monroy, Guillermo L.; South, Fredrick A.; Carney, P. Scott; Cradock, Kimberly A.; Liu, Z. George; Ray, Partha S.; Boppart, Stephen A.

doi:10.1117/12.2040315

Cited by 7 publications

(5 citation statements)

References 19 publications

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“…Furthermore, the presence of positive margins, which can be up to 30% , generally leads to further surgical resections with associated morbidity, resource utilization, anxiety, and delay. Optical biopsies have been recently used to potentially replace the current assessments where a pathologist examines the rim of normal tissue around the cancer to confirm it is clear of any cancer cells as the current pathological assessment remains time consuming and labor intensive and is not readily transferable to routine practice .…”

Section: Introductionmentioning

confidence: 99%

Time‐resolved fluorescence (TRF) and diffuse reflectance spectroscopy (DRS) for margin analysis in breast cancer

Shalaby

Al-Ebraheem

et al. 2018

Lasers Surg Med

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The work detailed in the main study showed the tr-FRS system has the potential to differentiate malignant from normal breast tissue in women undergoing surgery for known invasive ductal carcinoma. With further work, this successful outcome may result in the development of an accurate intraoperative real-time margin assessment system. Lasers Surg. Med. 50:236-245, 2018. © 2018 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Time‐resolved fluorescence (TRF) and diffuse reflectance spectroscopy (DRS) for margin analysis in breast cancer

Shalaby

Al-Ebraheem

et al. 2018

Lasers Surg Med

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“…Several pilot studies have explored the application of OCT to breast cancer imaging, including preclinical animal studies [17,18], human tissue imaging [19,20], and intraoperative imaging [21]. Currently a handheld OCT probe is being evaluated for in vivo margin assessment which allows tissue within the surgical cavity to be imaged prior to resection [22,23]. Other OCT techniques can also be used for breast imaging, including fullfield OCT for margin assessment [24], and OCT needle probes for biopsy assessment [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

South¹,

Chaney²,

Marjanović³

et al. 2014

Biomed. Opt. Express

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Successful treatment of breast cancer typically requires surgical removal of the tumor. Optical coherence tomography (OCT) has been previously developed for real-time imaging of the surgical margin. However, it can be difficult to distinguish between normal stromal tissue and cancer tissue based on scattering intensity and structure alone. Polarization-sensitive optical coherence tomography (PS-OCT) is sensitive to form birefringence of biological tissue. We report on the development of a high-speed PS-OCT system and imaging of ex vivo human breast tissue, showing enhanced contrast between healthy and cancerous tissues based upon collagen content confirmed with corresponding histology. These results demonstrate the feasibility of using PS-OCT to supplement structural OCT as a possible method for intraoperative tumor margin evaluation. References and links 1. American Cancer Society, Breast Cancer Facts & Figs. 2013 (American Cancer Society, Atlanta, GA, 2013. 2. B. Fisher, S. Anderson, J. Bryant, R. G. Margolese, M. Deutsch, E. R. Fisher, J.-H. Jeong, and N. Wolmark, "Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer," N. Engl. J. Med. 347(16), 1233-1241 (2002). 3. U. Veronesi, N. Cascinelli, L. Mariani, M. Greco, R. Saccozzi, A. Luini, M. Aguilar, and E. Marubini, "Twentyyear follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer," N. Engl. J. Med. 347(16), 1227-1232 (2002). 4. P. Ananthakrishnan, F. L. Balci, and J. P. Crowe, "Optimizing surgical margins in breast conservation," Int. J. Surg. Oncol. 2012, 585670 (2012 J. Keely, "Aligned collagen is a prognostic signature for survival in human breast carcinoma," Am. ©2014 Optical Society of America

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“…Additionally, a handheld OCT scanner [72] for intra-operatively assessing margins in excised breast tumor samples is currently being commercialized by Diagnostic Photonics, Inc. [73]. This scanner is also capable of assessing tissue within the excision cavity after tumor removal.…”

Section: Oct For Margin Assessmentmentioning

confidence: 99%

A review of optical coherence tomography in breast cancer

Scolaro

McLaughlin

Kennedy

et al. 2014

Photonics &Amp; Lasers in Medicine

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Optical coherence tomography (OCT) is a medical imaging modality that opens up new opportunities for imaging in breast cancer. It provides two-and threedimensional micro-scale images of tissue structure from bulk tissue, in vivo or freshly excised without labeling or staining, is capable of video-rate acquisition speeds, and is compatible with compact imaging probes. In this paper, the authors briefly describe OCT technology and describe in detail its capabilities for imaging breast cancer. Potential applications identified in current research are discussed, particularly in the assessment of excised breast tumors. It is concluded that OCT shows promise for margin assessment and biopsy guidance but that much more research and validation is required to confirm its level of utility. Zusammenfassung: Die optische Kohärenztomographie (optical coherence tomography, OCT) ist ein medizinisches Bildgebungsverfahren, das neue Möglichkeiten für die Bildgebung bei Brustkrebs eröffnet. Es liefert zweiund dreidimensionale Bilder im Mikrometerbereich; erlaubt die Darstellung von Gewebestrukturen großer Gewebevolumen, in vivo oder frisch exzidiert, ohne Markierung oder Färbung; arbeitet fast mit Videoaufnahmegeschwindigkeit und ist mit kompakten Imaging-Sonden kompatibel. Im vorliegenden Übersichtsartikel wird die OCT-Technologie kurz vorgestellt und deren Potential zur Bildgebung von Brustkrebs dargestellt. Mögliche Anwendungen, die derzeit Gegenstand aktueller Forschung sind, werden identifiziert und diskutiert, insbesondere ihr Einsatz zur Beurteilung exzidierter Brusttumoren. Die Autoren kommen zu dem Schluss, dass die OCT sich vielversprechend zeigt für die Tumorrandbestimmung und Biopsie-Führung, aber noch weitere Forschungsarbeit für die Validierung erforderlich ist, um den Grad des Nutzens zu bestätigen.

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In vivointra-operative breast tumor margin detection using a portable OCT system with a handheld surgical imaging probe

Cited by 7 publications

References 19 publications

Time‐resolved fluorescence (TRF) and diffuse reflectance spectroscopy (DRS) for margin analysis in breast cancer

Time‐resolved fluorescence (TRF) and diffuse reflectance spectroscopy (DRS) for margin analysis in breast cancer

Differentiation of ex vivo human breast tissue using polarization-sensitive optical coherence tomography

A review of optical coherence tomography in breast cancer

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