In vivo inhibition of the rat primary antibody response to antigenic stimulation by somatostatin

Abstract

Summary Somatostatin inhibits in vitro lymphocyte prohferative responses from a variety of species including human, mouse and rat. The immunoinhibitory effects of somatostatin are thought to involve binding to specific cell surface .somatostatin receptors on immunocompetent cells. This report describes an IM vivo immunoinhibitory effect of somatostatin on the rat pophteal lymph node lymphocyte primary antibody response to sheep red blood cell (SRBC) stimulation. Infusion of somatostatin immediately following SRBC injection into the hind feet of rats had a dose-related inhibitory effect. At the highest concentration used, 10 nmol/L, the level of inhibition was similar to that previously described following neonatal capsaicin treatment of rats. This suggests that neonatal capsaicin treatment may lead to decreased primary antibody responses to SRBC by a selective effect on tachykinin containing nerves and a lesser effect on somatostatin containing nerves. Tbe immunoinhibitory effect of somatostatin was reversed by co-infusion of neurokinin A but not substance P, botb of which have been shown to stimulate tbis response. This suggests tbe possibility tbat multiple tacbykinin receptors are involved in the modulation of the SRBC primary antibody response in vii'O. These results present evidence for an in viuo immunomodulatory role of somatostatin.

Relationship between Selection for Humoral Immune Response and Productive and Reproductive Traits in Fayoumi Male of Chicken

“…Also Davis , (1998) found that endocrine system is the main regulator of different environmental factors affecting immunity of birds , since , it help birds to successfully compete the viral challenges. This was also observed by many authors who claimed that hormones can modulate the immune system responses (Eglezos et al , 1993 andTrout andMashaly, 1995).…”

Neuropeptide receptors as potential drug targets in the treatment of inflammatory conditions

“…According to the current literature, neuropeptide receptors and the potential clinical relevance of the ligand SST 28 Neurogenic inflammation in rats, inhibits proliferation, chemotaxis, cytokine and immunoglobulin secretion of lymphocytes, monocytes and macrophages, murine EAE, rabbit acute pancreatitis [127,[132][133][134][135]147] sst2 sst3 sst5…”

“…A nonpeptide selective sst4 receptor agonist, J-2156, exhibited efficacy in similar animal models [128,131]. Somatostatin also decreases proliferation, chemotaxis and cytokine and immunoglobulin secretion by lymphocytes, monocytes and macrophages [132][133][134][135]. The beneficial effects of the SST analogues octreotide and pasireotide in murine antigen-induced arthritis were found to be mediated via sst2 and sst1 receptors, respectively [136].The sst4-receptorselective analogue J-2156 was also reported to inhibit the CFA-induced arthritis in the rat [131].…”

The role of cortistatin in the human immune system

“…In vivo treatment with octreotide completely abrogates IgG2 but not IgG1 or IgM secretion from granuloma cells (Blum et al, 1993). In vivo treatment of rats with somatostatin diminishes the number of antigen-specific plasma cells formed during a primary immune response, pointing to an effect on B cell activation, proliferation and/or differentiation (Eglezos et al, 1993). In vitro differentiation of human peripheral blood B lymphocytes into plasma cells is shown to be reduced by octreotide, indicating the involvement of sst 2 and/or sst 5 .…”