<i>In Vivo</i> Imaging-Guided Photothermal/Photoacoustic Synergistic Therapy with Bioorthogonal Metabolic Glycoengineering-Activated Tumor Targeting Nanoparticles

Du, Lili; Qin, Huan; Ma, Teng; Zhang, Tao; Xing, Da

doi:10.1021/acsnano.7b03226

Cited by 166 publications

(110 citation statements)

References 75 publications

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“…The photoacoustic (PA) shockwave, created by the cavitation (growth and collapse) of nanobubbles and microbubbles around nanoparticles heated by laser pulses, produces a strong and localized mechanical disruption of the tissue it comes into contact with . Our previous studies have demonstrated that a PA shockwave can be effective in producing localized cytotoxicity in nanoparticle‐targeted cells . The application of a nanoparticle activated by a pulsed laser to produce a PA shockwave is referred to as PA therapy.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood–Brain Barrier Permeability Upregulating Nanoparticle

Chen

Wen

et al. 2019

Adv Funct Materials

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Glioblastoma is an extremely difficult clinical indication with very few therapeutic choices. In this study, a nanoparticle is constructed featuring high red absorbance and selective penetration of the blood-brain barrier (BBB) at the tumor site. This nanoparticle can provide timely activation of the adenosine receptor on the BBB to allow self-passage and accumulation in the tumor. The nanoparticle converts pulsed laser energy into a shockwave via photoacoustic (PA) cavitation to achieve localized mechanical damage and thus yields a precision antitumor effect. In addition to its therapeutic function, the nanoparticle-mediated PA process can also generate images that provide valuable information regarding tumor depth, size, and vascular morphology to inform treatment planning and monitoring. The results show that the nanoparticles can be efficiently delivered into the glioblastoma via intravenous infusion and this PA shockwave therapy can selectively destroy glioblastoma tumors with no observable side effects on normal tissue. MCF-7 cells stained with CFSE, compared to the minimal signal in the U87-MG cells (Figure 4C, second column and fourth column). After PA therapy, U87-MG cells with Den-RCG/CGS/ Cy5.5 were destructed ( Figure 4C, first column, marked with the arrows). While the adjacent MCF-7 cells morphology maintain intact. These results suggest that, with a proper dosimetry, PA therapy could be a precise method to treat glioblastoma with minimal damage to the adjacent tissue.

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Section: Introductionmentioning

confidence: 99%

Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood–Brain Barrier Permeability Upregulating Nanoparticle

Chen

Wen

et al. 2019

Adv Funct Materials

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“…Unsurprisingly, glycoengineering represents an enabling technology for various biomedical applications, namely, both live cell, and extracellular vesicle labeling/tracking, drug‐based cancer theranostics, as well as cell‐based chemo‐ and immunotherapies . Despite an impressive body of literature on these recent advances, tissue engineering concepts exploiting this biomachinery phenomenon are still at their youth.…”

Section: Cell‐rich Assembliesmentioning

confidence: 99%

Advanced Bottom‐Up Engineering of Living Architectures

et al. 2019

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Bottom‐up tissue engineering is a promising approach for designing modular biomimetic structures that aim to recapitulate the intricate hierarchy and biofunctionality of native human tissues. In recent years, this field has seen exciting progress driven by an increasing knowledge of biological systems and their rational deconstruction into key core components. Relevant advances in the bottom‐up assembly of unitary living blocks toward the creation of higher order bioarchitectures based on multicellular‐rich structures or multicomponent cell–biomaterial synergies are described. An up‐to‐date critical overview of long‐term existing and rapidly emerging technologies for integrative bottom‐up tissue engineering is provided, including discussion of their practical challenges and required advances. It is envisioned that a combination of cell–biomaterial constructs with bioadaptable features and biospecific 3D designs will contribute to the development of more robust and functional humanized tissues for therapies and disease models, as well as tools for fundamental biological studies.

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“…Recently, several probes including photosensitizers (PSs) and photoacoustic agents that combine imaging and therapeutic functions have been introduced to tumors for imaging or image‐guided therapy based on bio‐orthogonal labeling . Owing to intrinsic signals from the probes, it is almost not possible to differentiate the target, such as tumors from normal organs or tissues during the initial several hours upon probe administration.…”

Section: Figurementioning

confidence: 99%

A Light‐Up Probe with Aggregation‐Induced Emission for Real‐Time Bio‐orthogonal Tumor Labeling and Image‐Guided Photodynamic Therapy

Mao

Kenry

et al. 2018

Angewandte Chemie

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Bio‐orthogonal tumor labeling is more effective in delivering imaging agents or drugs to a tumor site than active targeting strategy owing to covalent ligation. However, to date, tumor‐specific imaging through bio‐orthogonal labeling largely relies on body clearance to differentiate target from the intrinsic probe signal owing to the lack of light‐up probes for in vivo bio‐orthogonal labeling. Now the first light‐up probe based on a fluorogen with aggregation‐induced emission for in vivo bio‐orthogonal fluorescence turn‐on tumor labeling is presented. The probe has low background fluorescence in aqueous media, showing negligible non‐specific interaction with normal tissues. Once it reacts with azide groups introduced to tumor cells through metabolic engineering, the probe fluorescence is lightened up very quickly, enabling rapid tumor‐specific imaging. The photosensitizing ability was also used to realize effective image‐guided photodynamic tumor therapy.

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In Vivo Imaging-Guided Photothermal/Photoacoustic Synergistic Therapy with Bioorthogonal Metabolic Glycoengineering-Activated Tumor Targeting Nanoparticles

Cited by 166 publications

References 75 publications

Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood–Brain Barrier Permeability Upregulating Nanoparticle

Photoacoustic Therapy for Precise Eradication of Glioblastoma with a Tumor Site Blood–Brain Barrier Permeability Upregulating Nanoparticle

Advanced Bottom‐Up Engineering of Living Architectures

A Light‐Up Probe with Aggregation‐Induced Emission for Real‐Time Bio‐orthogonal Tumor Labeling and Image‐Guided Photodynamic Therapy

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