In Vivo Evaluation of Inorganic Nanoparticle Complexes against CCL4 Induced Hepatotoxicity

Abstract

Background: Combination of different chemotherapy drugs and nanoparticles as a carrier have shown promising delivery system in cancer treatment. Doxorubicin is considered as a potent anticancer drug. However, it’s off target activities and possible side effects, make its use limited. Recently, in the field of nanomedicine, different nanoconjugates have been developed as a unique platform for the delivery of therapeutic drugs. Objective: The aim of present study was to evaluate the best possible combination for efficient delivery of DOX with combination of gold, silver and zinc oxide nanoparticles to target site against carbon tetrachloride induced rat hepatotoxicity. Methodology: Effect of different conjugates administrated for 14 consecutive days was evaluated. Results: In comparison to DOX, Au:DOX, ZnoO:DOX and Ag:DOX showed less sign of liver fibrosis as evaluated by serum enzymes and histo-pathological analysis. However, among all the conjugates, Ag: DOX conjugate showed most significant results. The serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase values were (111.2 ± 38.21, 323.2 ± 46.88 and 303.6 ± 73.80 respectively) very close to control group (72.2 ± 19.41, 368 ± 59.78 and 259.4 ± 61.54 respectively). Conclusion: Our results demonstrated that Ag: DOX may exhibit hepato-protective activity against CCl4 induced liver damage.

Remodeling the hepatic fibrotic microenvironment with emerging nanotherapeutics: a comprehensive review

“…For example, metal oxide NPs (for example. Ag, ZnO, TiO2) induce M1 inflammatory cytokines in a dose-dependent manner [128,129].In addition, Au NPs are more effective than Ag NPs related to particle size [130]. Moreover, NPs not only induce polarization of macrophages but also reprogram them [131] SPION, glycocalyx-mimicking [132] and carbosilane dendrimer [133] induced a shift of M2 macrophages to M1 phenotype and restored the activity of CD8 + T cells, resulting in an immunological memory effect.…”

Comparison of the protective effects of CS/TPP and CS/HPMCP nanoparticles containing berberine in ethanol-induced hepatotoxicity in rat

“…Additionally, the protective effects of selenium nanoparticles were also observed in histopathological samples in preclinical models of hepatoxicity [ 26 ]. In another study by Tabbasam et al, the researchers investigated the protective effects of inorganic nanoparticle complexes against carbon tetrachloride-induced hepatotoxicity in preclinical mouse models [ 27 ]. In detail, these researchers generated three different types of nanoparticles (gold, silver, and zinc oxide) all loaded with doxorubicin.…”

“…According to the results, nanoparticle-assisted delivery of doxorubicin resulted in a reduced level of liver fibrosis. Moreover, they reported that silver nanoparticles loaded with doxorubicin outperformed the other types of nanoparticles by mediating the level of hepatic enzymes closest to the control group [ 27 ]. Overall, it was reported that drug-loaded silver nanoparticles demonstrated remarkable protective effects against carbon tetrachloride-induced hepatotoxicity [ 27 ].…”

“…Moreover, they reported that silver nanoparticles loaded with doxorubicin outperformed the other types of nanoparticles by mediating the level of hepatic enzymes closest to the control group [ 27 ]. Overall, it was reported that drug-loaded silver nanoparticles demonstrated remarkable protective effects against carbon tetrachloride-induced hepatotoxicity [ 27 ]. Based on these findings, we proposed that nanoparticles may be beneficial for the treatment of hepatoxicity.…”

Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity

“…Recently, a plethora of inorganic nanomaterials have been investigated for possible use as nanocarriers for liver fibrosis therapy. Among these, Au, Ag or Pt nanoparticles (NPs), which exhibit good biocompatibility with negligible toxic side effects, have been exploited 24 , 25 . Interestingly, owing to the synergistic effect of two components, bimetallic nanoalloys tend to exhibit superior chemical properties and better catalytic performance than single-component NPs.…”