<i>In Vivo</i>Efficacy of a Chimeric Peptide Derived from the Conserved Region of the M Protein against Group C and G Streptococci

Nordström, Therése; Malcolm, Jessica; Magor, Graham; Good, Michael F.; Batzloff, Michael R.

doi:10.1128/cvi.00140-12

Cited by 3 publications

(2 citation statements)

References 32 publications

(9 reference statements)

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“…Although published data on preclinical efficacy of vaccine candidates in SDSE is limited beyond preliminary data on the J8 peptide 47 , the prevalence of conserved antigens suggest there may be cross-species effects of vaccines intended to target S. pyogenes . However, the sequence-based approach used in this study does not consider potential conserved structural epitopes which may confer antibody cross-reactivity or cross-opsonisation to divergent alleles.…”

Section: Discussionmentioning

confidence: 99%

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

Xie,

Morris,

Hayes

et al. 2024

Nat Commun

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Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes. More than 75% of core genes are shared between the two species with one third demonstrating evidence of cross-species recombination. Twenty-five percent of mobile genetic element (MGE) clusters and 16 of 55 SDSE MGE insertion regions were shared across species. Assessing potential cross-protection from leading S. pyogenes vaccine candidates on SDSE, 12/34 preclinical vaccine antigen genes were shown to be present in >99% of isolates of both species. Relevant to possible vaccine evasion, six vaccine candidate genes demonstrated evidence of inter-species recombination. These findings demonstrate previously unappreciated levels of genomic overlap between these closely related pathogens with implications for streptococcal pathobiology, disease surveillance and prevention.

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Section: Discussionmentioning

confidence: 99%

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

Xie,

Morris,

Hayes

et al. 2024

Nat Commun

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show abstract

“…Over 25% of MGE insertion regions and MGE clusters were found to be conserved across Although published data on preclinical efficacy of vaccine candidates in SDSE is limited beyond preliminary data on the J8 peptide 46 , the prevalence of conserved antigens suggest there may be cross-species effects of vaccines intended to target S. pyogenes. However, the sequence-based approach used in this study does not consider potential conserved structural epitopes which may confer antibody cross-reactivity or cross-opsonisation to divergent alleles.…”

Section: Discussionmentioning

confidence: 99%

Inter-species gene flow drives ongoing evolution ofStreptococcus pyogenesandStreptococcus dysgalactiaesubsp.equisimilis

Xie

Morris

Hayes

et al. 2023

Preprint

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Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes. More than 75% of core genes are shared between the two species with one third demonstrating evidence of cross-species recombination. Twenty-five percent of mobile genetic element (MGE) clusters and 16 of 55 SDSE MGE insertion regions were found across species. Assessing potential cross-protection from leading S. pyogenes vaccine candidates on SDSE, 12/34 preclinical vaccine antigen genes were shown to be present in >99% of isolates of both species. Relevant to possible vaccine evasion, six vaccine candidate genes demonstrated evidence of inter-species recombination. These findings demonstrate previously unappreciated levels of genomic overlap between these closely related pathogens with implications for streptococcal pathobiology, disease surveillance and prevention.

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Streptococcus dysgalactiae subsp. equisimilis infection and its intersection with Streptococcus pyogenes

Xie,

Davies,

Tong

2024

Clin Microbiol Rev

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SUMMARY Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an increasingly recognized cause of disease in humans. Disease manifestations range from non-invasive superficial skin and soft tissue infections to life-threatening streptococcal toxic shock syndrome and necrotizing fasciitis. Invasive disease is usually associated with co-morbidities, immunosuppression, and advancing age. The crude incidence of invasive disease approaches that of the closely related pathogen, Streptococcus pyogenes . Genomic epidemiology using whole-genome sequencing has revealed important insights into global SDSE population dynamics including emerging lineages and spread of anti-microbial resistance. It has also complemented observations of overlapping pathobiology between SDSE and S. pyogenes , including shared virulence factors and mobile gene content, potentially underlying shared pathogen phenotypes. This review provides an overview of the clinical and genomic epidemiology, disease manifestations, treatment, and virulence determinants of human infections with SDSE with a particular focus on its overlap with S. pyogenes . In doing so, we highlight the importance of understanding the overlap of SDSE and S. pyogenes to inform surveillance and disease control strategies.

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In VivoEfficacy of a Chimeric Peptide Derived from the Conserved Region of the M Protein against Group C and G Streptococci

Cited by 3 publications

References 32 publications

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis

Inter-species gene flow drives ongoing evolution ofStreptococcus pyogenesandStreptococcus dysgalactiaesubsp.equisimilis

Streptococcus dysgalactiae subsp. equisimilis infection and its intersection with Streptococcus pyogenes

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