In Vivo Efficacy of a Novel, Sutureless Coaptation Device for Repairing Peripheral Nerve Defects

Conductive and alignment-optimized porous fiber conduits with electrical stimulation for peripheral nerve regeneration

“…When the sciatic nerve is damaged in rats, there may be a loss of innervation in the GM and a potential shift towards protein degradation in muscle protein homeostasis. This could result in reduced muscle cell volume, weight loss, neovascularization, and increased connective tissue proliferation [ 83 ]. The GMs in all groups exhibited atrophy compared to the healthy sides ( Fig.…”

MRI and Ultrasound Visualization of a Nerve Repair Implant Containing Nitinol

“…7 In preclinical testing, NT has been shown to provide superior nerve conduction recovery and comparable axon regeneration efficacy when compared with microsuture or conduit-assisted repairs. 4 Despite recent advancements in magnetic resonance imaging (MRI) and ultrasound technology, postoperative imaging of the nerve repair site is infrequently obtained in routine clinical practice. Although diagnostic imaging cost and complexity are undoubtedly contributing factors, another challenge arises from the difficulty in identifying the suture material that delineates the neurorrhaphy repair site.…”

“…The current standard for direct nerve repair is microsuture neurorrhaphy, a technique requiring advanced technical skills and with varying repair efficacy, ranging from 24% to 81%, 3 in part due to difficulties in nerve approximation. 4 Proper fascicular alignment, nerve coaptation without tension, and nerve stump debridement are crucial factors that impact outcomes.…”

“…designed to grip and stabilize tissue, are embedded within a thin, flexible backing layer of decellularized porcine small intestinal submucosa (SIS). 4 (See figure, Supplemental Digital Content 1, which displays NT structure and application in nerve repair. A, NT contains columns of nitinol microhooks integrated within a biologic backing layer.…”