“…Our previous investigations, demonstrating quite unusual haemodynamic and capillary effects of the endothelins in muscle tissue (Ekelund et al, 1993;Ekelund, 1994), suggested that they might be of importance in long-term, rather than short-term, regulation of vascular tone in vivo, perhaps especially during pathophysiological conditions. From the present results, it may be concluded that ETB-receptor stimulation is responsible for the dilator response, and can contribute to the constrictor response, elicited by the endothelins in skeletal muscle in vivo.…”