<i>In Vivo</i>Effects of Chicken Interferon-γ During Infection with<i>Eimeria</i>

Lowenthal, John W.; York, Jennifer J.; O’Neil, Terri E.; Rhodes, Steven; Prowse, Stephen J.; Strom, Alexander; Digby, Matthew R.

doi:10.1089/jir.1997.17.551

Cited by 113 publications

(52 citation statements)

References 23 publications

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“…There is a correlation between resistance to these diseases and early and higher IFN-γ production. A high level of IFN-γ production has also been shown in chicken strains that are resistant to coccidiosis [20,90,139]. These observations suggest that chicken lines with an enhanced IFN-γ response are more resistant to some viral and parasitic infections.…”

Section: Cytokinesmentioning

confidence: 76%

Immunological basis of differences in disease resistance in the chicken

Zekarias

Huurne²,

Landman

et al. 2002

Vet. Res.

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-Genetic resistance to diseases is a multigenic trait governed mainly by the immune system and its interactions with many physiologic and environmental factors. In the adaptive immunity, T cell and B cell responses, the specific recognition of antigens and interactions between antigen presenting cells, T cells and B cells are crucial. It occurs through a network of mediator proteins such as the molecules of the major histocompatibility complex (MHC), T cell receptors, immunoglobulins and secreted proteins such as the cytokines and antibodies. The diversity of these proteins that mainly is due to an intrinsic polymorphism of the genes causes phenotypic variation in disease resistance. The well-known linkage of MHC polymorphism and Marek's disease resistance difference represents a classic model revealing immunological factors in resistance differences and diversity of mediator molecules. The molecular bases in any resistance variation to infectious pathogens are vaguely understood. This paper presents a review of the major immune mediators involved in resistance and susceptibility to infectious diseases and their functional mechanisms in the chicken. The genetic interaction of disease resistance with production traits and the environment is mentioned. et les interactions entre les cellules présentant des antigènes, les cellules T et B, sont cruciales. Cela se produit à travers un réseau de protéines médiatrices telles que les molécules du complexe majeur d'histocompatibilité (CMH), les récepteurs des cellules T, les immunoglobulines et les protéines sé-crétées telles que les cytokines et les anticorps. La diversité de ces protéines, qui est surtout due au polymorphisme intrinsèque des gènes, entraîne une variation phénotypique dans la résistance aux maladies. Le lien bien connu entre le polymorphisme du CMH et les différences dans la résistance à la maladie de Marek représente un modèle classique révélant les facteurs immunologiques dans les différences de résistance et la diversité dans les molécules médiatrices. Les bases moléculaires impliquées dans toute variation de résistance aux pathogènes infectieux sont à peu près comprises. Cet article présente une synthèse sur les principaux médiateurs de l'immunité impliqués dans la résis-tance et la sensibilité aux maladies infectieuses chez le poulet et leurs mécanismes fonctionnels. L'interaction génétique entre la résistance aux maladies et les traits de production et l'environnement est mentionnée.

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Section: Cytokinesmentioning

confidence: 76%

Immunological basis of differences in disease resistance in the chicken

Zekarias

Huurne²,

Landman

et al. 2002

Vet. Res.

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“…Therefore, ChIFN-γ probably work for Th1 immune response as reported in mammalian model [4,15]. In chickens, IL- 12 has not yet been cloned, but the cloning of chicken IL-18, which will work synergistically with IL-12, has recently been described [18]. If IL-12 of chicken is cloned in future, it seems that co-administration of IL-12 and IL-18 will increase IFN-γ production and work for Th1 responses showing a strong adjuvant activity even in chickens.…”

Section: Discussionmentioning

confidence: 88%

“…Lowenthal et al [11] showed enhancement of antibody responses in chickens co-administered of ChIFN-γ with sheep red blood cells. Lowenthal et al [12] also reported in vivo effects of ChIFN-γ administration during infection with Eimeria. So far most reports on ChIFN-γ and disease deal with coccidiosis [9,10,25].…”

mentioning

confidence: 97%

Adjuvant Effect of Chicken Interferon-.GAMMA. for Inactivated Salmonella Enteritidis Antigen

Takehara

Kobayashi

Ruttanapumma

et al. 2003

The Journal of Veterinary Medical Science

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ABSTRACT. The adjuvant effect of chicken interferon-γ (ChIFN-γ) was examined for protecting chickens against intestinal colonization of Salmonella Enteritidis (SE) following oral exposure. Ten 7-week-old chickens per group were immunized with inactivated SE twice with or without co-administration of ChIFN-γ intramuscularly, and all chickens were challenged with SE. Sera collected from immunized groups with or without ChIFN-γ, and from unimmunized group were measured for SE antibody by agglutination test. The levels of antibodies were raised by 1 week post-immunization and did not show any difference between groups with and without ChIFN-γ. No antibodies were detected in unimmunized group before challenge. Fecal samples from each group were cultured at 1, 4, 7, and 13 days postchallenge to determine the incidence of intestinal colonization and the numbers of SE shed into the environment. Co-administration of ChIFN-γ, significantly reduced the incidence of intestinal colonization (P<0.05). At 13 days post-challenge, the bacterial counts of SE in organs were also reduced in ChIFN-γ administered group. These data suggest co-administration of ChIFN-γ with SE antigen enhances protection against SE challenge without acceleration of antibody production.

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“…These results suggest that IFN-a protected the birds directly due to its intrinsic antiviral activity; whereas IFN-g protected the birds indirectly by potentiating the host immune response. Similarly, birds administered recombinant chicken IFN-g prophylactically before a coccidial challenge were found to have an increased weight gain and decreased oocyst production (Lowenthal et al, 1997;Lillehoj & Choi, 1998). The in ovo injection of recombinant cMGF reduced mortality due to Escherichia coli in the hatcher (Johnston et al, 1995).…”

Section: Cytokines As Therapeutic Agentsmentioning

confidence: 99%

Cytokines and prevention of infectious diseases in poultry: A review

Kogut

2000

Avian Pathology

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Cytokines are soluble, low molecular weight polypeptides and glycopeptides produced by a broad range of cell types of haematopoietic and nonhaematopoietic origin that have suppressive or enhansive effects on cellular proliferation, differentiation, activation, and motility. Like hormones, cytokines mediate cellular responses through autocrine, paracrine, and endocrine activities. Both inflammatory responses and specific immune responses to invasive microbes, which were evolved to protect the host from pathogens, are controlled by a complex network of cytokines. As regulators of the initiation and maintenance of host defenses, cytokines ultimately determine the type of response generated and the effector mechanisms generated to mediate resistance. As effector molecules, cytokines are produced transiently and locally to control the amplitude and duration of the response. Likewise, excessive or insufficient production of a cytokine or cytokines may contribute significantly to the pathophysiology of disease. Therefore, cytokines play pivotal but paradoxical roles in both in the regulation of inflammation and immunity. The use of exogenous cytokines against infectious agents in poultry medicine has centered on: (a) their use as adjuvants for vaccines, (b) their direct effects on inducing protection against infections and/or the undesired effects of immune responses elicited by pathogens, and (c) their ability to stimulate the ontogeny and activation of neonatal host defenses. This monograph will review what has been reported about the use of cytokines in poultry in these three main areas.

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In VivoEffects of Chicken Interferon-γ During Infection withEimeria

Cited by 113 publications

References 23 publications

Immunological basis of differences in disease resistance in the chicken

Immunological basis of differences in disease resistance in the chicken

Adjuvant Effect of Chicken Interferon-.GAMMA. for Inactivated Salmonella Enteritidis Antigen

Cytokines and prevention of infectious diseases in poultry: A review

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