In VivoComparison of Hard Tissue Regeneration with Human Mesenchymal Stem Cells Processed with Either the FICOLL Method or the BMAC Method

Abstract

MSCs harvested from bone marrow aspirate in combination with bovine bone matrix particles can form lamellar bone and provide a reliable base for dental implants. The closed BMAC system is suited to substitute the open FICOLL system in bone regeneration procedures.

Mesenchymal Stem Cells for Optimizing Bone Volume at the Dental Implant Recipient Site

“…Recent literatures have showed the potential benefits of using a cocktail of mononuclear cells without expanding them in vitro before reimplantation [36] (Figure 5). Therefore, there are also various systems developed for harvesting of MSCs from bone marrow.…”

“…Therefore, there are also various systems developed for harvesting of MSCs from bone marrow. One of these is the bone marrow-derived MNCs isolation by synthetic poylsaccharid (FICOLL), technique, which is currently accepted as the gold standard [36,37]. The FICOLL method might present a useful technique for hospitals; however, the system is a time-consuming one, and a good manufacturing practice (GMP) laboratory is required.…”

“…To ensure the clinical use in operating facilities without GMP possibilities, closed systems such as closed bone marrow aspirate concentrate (SmartPReP2 Bone Marrow Aspirate Concentrate System; BMAC; Harvest Technologies GmbH) system were developed [38]. Saurbier et al [36] have compared new bone formation in maxillary sinus augmentation procedures using biomaterial associated with MSCs separated by FICOLL and BMAC and observed a higher proportion of hard tissue in the BMAC group.…”

Dental Kök Hücre Kaynaklari Ve Kemi̇k Doku Rejenerasyonunda Kullanilma Potansi̇yelleri̇

“…62 Sauerbier ve arkadaşları mezenkim kök hücrelerinin implanta destek sağlayabilecek kemiği oluşturduğunu bildirmişlerdir. 63 Yamada ve ark.nın 67 çalışmalarında; mezenkim kök hücresi kemik-implant ara yüzeyinde temas alanı elde edilmiştir. [64][65][66] Marei ve arkadaşları mezenkimal kök hücre uygulamalarında kemik rejenerasyonun elde edildiğini bildirmiştir.…”

Traditional and Current Treatment Methods from Apexification to Apexogenesis

“…Sauerbier ve ark. 28 , mezenkimal kök hücreleri (MSC) içeren biyomateryallerin maksiller sinüs augmentasyonunda yeterli kemik rejenerasyonunu sağladığını bildirmişlerdir. Ji ve ark.…”