<i>In Vivo</i> Cancer Targeting and Imaging-Guided Surgery with Near Infrared-Emitting Quantum Dot Bioconjugates

Li, Yan; Li, Zhe; Wang, Xiaohui; Liu, Fengjun; Cheng, Ying-Sheng; Zhang, Bingbo; Shi, Donglu

doi:10.7150/thno.4690

Cited by 59 publications

(43 citation statements)

References 52 publications

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“…In vivo, the margins of tumor and the tumor itself were visualized and distinguished by the resulted QDs. Moreover, the tumor resection was successfully visualized through NIR imaging 83 . Except for the inorganic contrast agents, some dyes also can be used to monitor the pathway of polymeric nanoparticles in vivo.…”

Section: Polymeric/quantum Dotsmentioning

confidence: 99%

Polymeric multifunctional nanomaterials for theranostics

et al. 2015

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Nanocarriers provide a platform to integrate therapy and diagnostics, which is an emerging direction in medical practice. Beyond simply therapeutic functionality, theranostic nanomaterials have been designed to deliver multiple components and imaging agents, facilitating simultaneous and synergistic diagnosis and therapies. In this article, polymeric materials with diverse functionalities and properties for manufacturing theranostic nanomaterials are discussed and compared. We focused on recent advancements in polymeric multifunctional nanomaterials for synergistic theranostics. The drugs and imaging agents were encapsulated within and/or conjugated to the surface of the nanocarriers, according to the fabrication process and carrier type. In parallel with therapy, polymeric multifunctional nanomaterials can be exploited to exhibit distinctive magnetic, electrical, and optical properties for concomitant imaging. This has been accomplished by incorporating various imaging agents, such as fluorescent dyes, biomarkers, quantum dots, metal composites, and magnetic nanoparticles. We discussed theranostic nanomaterial synthesis, carrier fabrication and its applications. By presenting this comprehensive review of the state-of-the-art, we demonstrated that polymeric multifunctional nanomaterials exhibit distinctive advantages and features in theranostics. DisciplinesBiomechanics and Biotransport | Nanoscience and Nanotechnology | Polymer This is an Accepted Manuscript, which has been through the Royal Society of Chemistry peer review process and has been accepted for publication.Accepted Manuscripts are published online shortly after acceptance, before technical editing, formatting and proof reading. Using this free service, authors can make their results available to the community, in citable form, before we publish the edited article. We will replace this Accepted Manuscript with the edited and formatted Advance Article as soon as it is available.You can find more information about Accepted Manuscripts in the Information for Authors.

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Section: Polymeric/quantum Dotsmentioning

confidence: 99%

Polymeric multifunctional nanomaterials for theranostics

et al. 2015

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“…NIR NPs undoubtedly will play a critical role in targeted surgery. One of the classic applications of nanometer-sized NIRF probes is intraoperative assessment of the sentinel lymph node (SLN) for the presence of tumor cells by local injection of nanoprobes[42], or identification of tumor by nanoprobes such as QDs functionalized with arginine-glycine-aspartic (RGD) peptide[43]. Certain nanoprobes have demonstrated efficacy in cellular imaging of tissue samples in clinic[44].…”

Section: Target-specific Fluorescent Probes: the Driving Force Formentioning

confidence: 99%

Fluorescent imaging of cancerous tissues for targeted surgery

Bu¹,

Shen

Cheng

2014

Advanced Drug Delivery Reviews

108

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To maximize tumor excision and minimize collateral damage is the primary goal of cancer surgery. Emerging molecular imaging techniques have to “image-guided surgery” developing into “molecular imaging-guided surgery”, which is termed “targeted surgery” in this review. Consequently, the precision of surgery can be advanced from tissue-scale to molecule-scale, enabling “targeted surgery” to be a component of “targeted therapy”. Evidence from numerous experimental and clinical studies has demonstrated significant benefits of fluorescent imaging in targeted surgery with preoperative molecular diagnostic screening. Fluorescent imaging can help to improve intraoperative staging and enable more radical cytoreduction, detect obscure tumor lesions in special organs, highlight tumor margins, better map lymph node metastases, and identify important normal structures intraoperatively. Though limited tissue penetration of fluorescent imaging and tumor heterogeneity are two major hurdles for current targeted surgery, multimodality imaging and multiplex imaging may provide potential solutions to overcome these issues, respectively. Moreover, though many fluorescent imaging techniques and probes have been investigated, targeted surgery remains at a proof-of-principle stage. The impact of fluorescent imaging on cancer surgery will likely be realized through persistent interdisciplinary amalgamation of research in diverse fields.

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“…b NIR imaging-guided surgery performed 48 h after injection; and c the solid tumor precisely removed. From Li et al (2012) Indeed, the particles showed very high optical absorption coefficient, the highest T1 relaxivity reported for a nanoparticles at the time (3 9 10 6 m/ Ms), and a unique Raman signature, which allowed their detection in vitro at picomolar concentration with both MRI and optoacoustic techniques and femtomolar concentration with Raman imaging. Since the astonishing detectability, authors attempted to verify threshold levels also in vivo through subcutaneous injection of the particles dispersed in matrigel in living mice founding that Raman imaging, thanks to absence of tissue background signal, maintained the best detection thresholds (50 pM), while the two other techniques required higher concentrations (Fig.…”

Section: Hard Nanoparticles-based Systemsmentioning

confidence: 99%

Hard and soft nanoparticles for image-guided surgery in nanomedicine

Locatelli¹,

Monaco²,

Franchini³

2015

J Nanopart Res

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The use of hard and/or soft nanoparticles for therapy, collectively called nanomedicine, has great potential in the battle against cancer. Major research efforts are underway in this area leading to development of new drug delivery approaches and imaging techniques. Despite this progress, the vast majority of patients who are affected by cancer today sadly still need surgical intervention, especially in the case of solid tumors. An important perspective for researchers is therefore to provide even more powerful tools to the surgeon for pre-and post-operative approaches. In this context, image-guided surgery, in combination with nanotechnology, opens a new strategy to win this battle. In this perspective, we will analyze and discuss the recent progress with nanoparticles of both metallic and biomaterial composition, and their use to develop powerful systems to be applied in image-guided surgery.

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In Vivo Cancer Targeting and Imaging-Guided Surgery with Near Infrared-Emitting Quantum Dot Bioconjugates

Cited by 59 publications

References 52 publications

Polymeric multifunctional nanomaterials for theranostics

Polymeric multifunctional nanomaterials for theranostics

Fluorescent imaging of cancerous tissues for targeted surgery

Hard and soft nanoparticles for image-guided surgery in nanomedicine

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