<i>In vivo</i> biocompatibility of ZIF-8 for slow release <i>via</i> intranasal administration

Kumari, Sunita; Howlett, Thomas; Ehrman, Ryanne N.; Koirala, Shailendra; Trashi, Orikeda; Trashi, Ikeda; Wijesundara, Yalini H.; Gassensmith, Jeremiah J.

doi:10.1039/d3sc00500c

Cited by 17 publications

(17 citation statements)

References 42 publications

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“…More recently, Kumari et al demonstrated how coating liposomes in ZIF and delivering them intranasally into mice can extend the bioresidency half-life of the liposomes by over four times. 171 Further, they were able to deliver up to 1 mg of uncoated ZIF-8 directly into the intranasal cavity and observed no tissue damage to the delicate turbinate structures in the sinuses, nor loss of pulmonary function or elevation of liver and kidney enzymes, showing this route as being highly compatible with MOF delivery. These efforts�although nascent and still in the stage of fundamental discovery� show potential for the possible marriage of all aforementioned benefits of MOFs as vaccine carriers along with being able to exploit them as a tool for mucosal delivery.…”

Section: Needle-free Deliverymentioning

confidence: 92%

“…These results were impressive as they were able to deliver up to 8 mg into the lungs and, according to histopathological analyses, without damaging the tissues. More recently, Kumari et al demonstrated how coating liposomes in ZIF and delivering them intranasally into mice can extend the bioresidency half-life of the liposomes by over four times . Further, they were able to deliver up to 1 mg of uncoated ZIF-8 directly into the intranasal cavity and observed no tissue damage to the delicate turbinate structures in the sinuses, nor loss of pulmonary function or elevation of liver and kidney enzymes, showing this route as being highly compatible with MOF delivery.…”

Section: Advantages Of Using Mofs/cofs To Fill the Gap In Current Vac...mentioning

confidence: 99%

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The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Wijesundara,

Howlett,

Kumari

et al. 2024

Chem. Rev.

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The immune system's complexity and ongoing evolutionary struggle against deleterious pathogens underscore the value of vaccination technologies, which have been bolstering human immunity for over two centuries. Despite noteworthy advancements over these 200 years, three areas remain recalcitrant to improvement owing to the environmental instability of the biomolecules used in vaccines�the challenges of formulating them into controlled release systems, their need for constant refrigeration to avoid loss of efficacy, and the requirement that they be delivered via needle owing to gastrointestinal incompatibility. Nanotechnology, particularly metal−organic frameworks (MOFs) and covalent organic frameworks (COFs), has emerged as a promising avenue for confronting these challenges, presenting a new frontier in vaccine development. Although these materials have been widely explored in the context of drug delivery, imaging, and cancer immunotherapy, their role in immunology and vaccine-related applications is a recent yet rapidly developing field. This review seeks to elucidate the prospective use of MOFs and COFs for biomaterial stabilization, eliminating the necessity for cold chains, enhancing antigen potency as adjuvants, and potentializing needle-free delivery of vaccines. It provides an expansive and critical viewpoint on this rapidly evolving field of research and emphasizes the vital contribution of chemists in driving further advancements. CONTENTS 1. Introduction to Vaccines and Immuno-Therapeutics and Current Limitations in the Landscape of Vaccine Technology 3013 2. Unique Structural Features of MOFs/COFs 3015 3. Advantages of Using MOFs/COFs To Fill the Gap in Current Vaccine Technology 3017 3.1. Thermodynamic Stability of MOFs 3017 3.2. Kinetic Lability 3019 3.3. Functional Modification 3019 3.4. Needle-Free Delivery 3019 4.

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Section: Needle-free Deliverymentioning

confidence: 92%

Section: Advantages Of Using Mofs/cofs To Fill the Gap In Current Vac...mentioning

confidence: 99%

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Wijesundara,

Howlett,

Kumari

et al. 2024

Chem. Rev.

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“…The high extent of 20 nm NPs' structural degradation upon exposure to DIFP down to ultrasmall 7 nm NPs should be considered beneficial to avoid NP bioaccumulation facilitating their body clearance. 23 The size dependence of ZIF structural degradation is also reflected in the high linker release with [mIm] reaching 0.05 M for the nanometer-sized particles (Table S3). ZIF Nerve Agent Detoxification: Dual P−F Bond Breakdown and AChE Reactivation.…”

Section: ■ Experimental Sectionmentioning

confidence: 98%

“…It is noteworthy that the structural degradation is advantageous since it prevents the accumulation of nanoparticles (NPs) in the body . Indeed, in vivo biosafety of ZIF-8 NPs and degradation products thereof has been recently demonstrated …”

Section: Introductionmentioning

confidence: 99%

“…22 Indeed, in vivo biosafety of ZIF-8 NPs and degradation products thereof has been recently demonstrated. 23 In addition, zinc-azolate MOFs (including some examples of ZIFs) have been shown to exhibit catalytic activity toward the degradation of organophosphorus compounds, mimicking the active site of phosphohydrolase enzymes as a consequence of a suitable balance of Zn Lewis acidity and linker basicity. 24−27 However, all previous reports require strong basic buffered media (pH 9−11) to exhibit hydrolase-like activity, which is far from physiological conditions (pH 7.4).…”

Section: ■ Introductionmentioning

confidence: 99%

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Organophosphate Detoxification and Acetylcholinesterase Reactivation Triggered by Zeolitic Imidazolate Framework Structural Degradation

Martin-Romera,

Borrego-Marin,

Jabalera-Ortiz

et al. 2024

ACS Appl. Mater. Interfaces

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Organophosphate (OP) toxicity is related to inhibition of acetylcholinesterase (AChE) activity, which plays a key role in the neurotransmission process. In this work, we report the ability of different zinc zeolitic imidazolate frameworks (ZIFs) to behave as potential antidotes against OP poisoning. The Zn−L coordination bond (L = purine, benzimidazole, imidazole, or 2methylimidazole) is sensitive to the G-type nerve agent model compounds diisopropylfluorophosphate (DIFP) and diisopropylchlorophosphate, leading to P−X (X = F or Cl) bond breakdown into nontoxic diisopropylphosphate. P−X hydrolysis is accompanied by ZIF structural degradation (Zn−imidazolate bond hydrolysis), with the concomitant release of the imidazolate linkers and zinc ions representing up to 95% of ZIF particle dissolution. The delivered imidazolate nucleophilic attack on the OP@AChE adduct gives rise to the recovery of AChE enzymatic function. P−X bond breakdown, ZIF structural degradation, and AChE reactivation are dependent on imidazolate linker nucleophilicity, framework topology, and particle size. The best performance is obtained for 20 nm nanoparticles (NPs) of Zn(2-methylimidazolate) 2 (sod ZIF-8) exhibiting a DIFP degradation half-life of 2.6 min and full recovery of AChE activity within 1 h. 20 nm sod ZIF-8 NPs are not neurotoxic, as proven by in vitro neuroblastoma cell culture viability tests.

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Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

Wang,

Walden,

Ettlinger

et al. 2023

Adv Funct Materials

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Metal–organic framework (MOF) materials are gaining significant interest in biomedical research, owing to their high porosity, crystallinity, and structural and compositional diversity. Their versatile hybrid organic/inorganic chemistry endows MOFs with the capacity to retain organic (drug) molecules, metals, and gases, to effectively channel electrons and photons, to survive harsh physiological conditions such as low pH, and even to protect sensitive biomolecules. Extensive preclinical research has been carried out with MOFs to treat several pathologies and, recently, their integration with other biomedical materials such as stents and implants has demonstrated promising performance in regenerative medicine. However, there remains a significant gap between MOF preclinical research and translation into clinically and societally relevant medicinal products. Here, the intrinsic features of MOFs are outlined and their suitability to specific biomedical applications such as detoxification, drug and gas delivery, or as (combination) therapy platforms is discussed. Furthermore, relevant examples of how MOFs have been engineered and evaluated in different medical indications, including cancer, microbial, and inflammatory diseases is described. Finally, the challenges facing their translation into the clinic are critically examined, with the goal of establishing promising research directions and more realistic approaches that can bridge the translational gap of MOFs and MOF‐containing (nano)materials.

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In vivo biocompatibility of ZIF-8 for slow release via intranasal administration

Abstract: Studying the toxicity of zeolitic imidazolate framework-8 (ZIF-8) in context of intranasal administration will help researchers in building depot platforms for this non-invasive route of delivery.

Cited by 17 publications

References 42 publications

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Organophosphate Detoxification and Acetylcholinesterase Reactivation Triggered by Zeolitic Imidazolate Framework Structural Degradation

Biomedical Metal–Organic Framework Materials: Perspectives and Challenges

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