<i>In vivo</i> assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging

Xie, Zhihua; Yang, Yanqing; He, Yang; Shu, Chengyou; Chen, Dong; Zhang, Jinke; Chen, Jingqin; Liu, Chengbo; Sheng, Zonghai; Liu, Huadong; Liu, Jie; Gong, Xiaojing; Liu, Song; Dong, Shaohong

doi:10.7150/thno.41211

Cited by 56 publications

(39 citation statements)

References 43 publications

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“…In this study, ApoE -/mice were placed in a carotid artery neck ring combined with a high-fat diet to establish an animal model of carotid atherosclerosis (survival rate after surgery was 100%) to explore the mechanism of BBR in improving the disease. Studies have shown that high-fat diet feeding increases the blood viscosity of mice, while the placement of the collar affects local blood circulation, which is based on local changes in the hemodynamic state of the carotid artery, which leads to carotid atherosclerosis [29]. Therefore, this animal model is similar to the pathophysiological conditions of human atherosclerosis and is considered a suitable research object [30][31][32].…”

Section: Discussionmentioning

confidence: 99%

Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway

Song

Chen

2021

Bioengineered

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Atherosclerosis, a multifactorial vascular disease resulting from lipid metabolism disorders, features chronic inflammatory damage resulting from endothelial dysfunction, which usually affects multiple arteries. The carotid artery is a common site for clinical atherosclerosis evaluation. The aortic root is the standard site for quantifying atherosclerosis in mice. Due to the adverse reactions of first-line drugs, it is necessary to discover new drugs to prevent and treat atherosclerosis. Berberine (BBR) is one of the most promising natural products derived from herbal medicine Coptidis Rhizoma (Huanglian) that features significant anti-atherosclerosis properties. However, overall BBR mechanism against carotid atherosclerosis has not been clearly discovered. Our work aimed to investigate potential BBR mechanism in improving carotid atherosclerosis in ApoE knockout mice. Here, we proved that in ApoE -/mice receiving high-fat diet for 12 weeks, BBR can reduce serum lipid levels, improve intimal hyperplasia, and antagonize carotid lipid accumulation, which may be achieved through regulating the PI3K/AKT/mTOR signaling pathway, regulating autophagy, promoting cell proliferation and inhibiting cell apoptosis. In summary, these data indicate that BBR can ameliorate carotid atherosclerosis. Therefore, it could be a promisingly therapeutic

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Section: Discussionmentioning

confidence: 99%

Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway

Song

Chen

2021

Bioengineered

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“…It is notable that IVPA offered three-dimensional position information as well as accurate photoacoustic signals of the components. The obtained comprehensive information is valuable in assessing the severity and vulnerability of atherosclerotic plaques and potentially enabling the development of improved interventional treatment for atherosclerosis [ 54 ]. Although the imaging system was successfully applied in lipid and neovascularization detection, the in vivo identification of lipids was not achieved in this study due to the high absorption of blood and water at 1720 nm.…”

Section: Discussionmentioning

confidence: 99%

IVUS\IVPA hybrid intravascular molecular imaging of angiogenesis in atherosclerotic plaques via RGDfk peptide-targeted nanoprobes

Lin

Xie

et al. 2021

Photoacoustics

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Current intravascular imaging modalities face hurdles in the molecular evaluation of progressed plaques. This study aims to construct a novel hybrid imaging system (intravascular ultrasound/intravascular photoacoustic, IVPA/IVUS) via RGDfk peptide-targeted nanoparticles for monitoring angiogenesis in progressed atherosclerotic plaques in a rabbit model. An atherosclerotic rabbit model was induced by abdominal aorta balloon de-endothelialization followed by a high-fat diet. A human serum albumin (HSA)-based nanoprobe modified with RGDfk peptide was constructed by encapsulating indocyanine green (ICG) via electrostatic force (ICG-HSA-RGDfk NPs, IHR-NPs). A hybrid intravascular imaging system that combined IVUS and IVPA was self-assembled for RGDfk visualization within atherosclerotic plaques in the rabbit abdominal aorta. Through IHR-NPs and the hybrid IVUS/IVPA imaging platform, multiple comprehensive pieces of information on progressed plaques, including anatomical information, composition information and molecular information, can be obtained simultaneously, which may improve the precise diagnosis of plaque characteristics and the evaluation of early interventions for atherosclerosis.

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“…Other studies aimed to increase the specificity of OAI for identification of carotid atherosclerosis by targeted approaches. An example is a study which used CD36-labeled semiconducting polymer nanoparticles in combination with OAI to identify the extent of the inflammation of carotid atherosclerosis in mice [ 56 ]. CD36 is a membrane glycoprotein present on various inflammatory cell types including monocytes, macrophages, endothelial cells, adipocytes, and platelets, which are all significantly involved in atherogenic processes [ 113 ].…”

Section: Optoacoustic Imaging Of Inflammation: Applicationsmentioning

confidence: 99%

Optoacoustic Imaging in Inflammation

et al. 2021

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Optoacoustic or photoacoustic imaging (OAI/PAI) is a technology which enables non-invasive visualization of laser-illuminated tissue by the detection of acoustic signals. The combination of “light in” and “sound out” offers unprecedented scalability with a high penetration depth and resolution. The wide range of biomedical applications makes this technology a versatile tool for preclinical and clinical research. Particularly when imaging inflammation, the technology offers advantages over current clinical methods to diagnose, stage, and monitor physiological and pathophysiological processes. This review discusses the clinical perspective of using OAI in the context of imaging inflammation as well as in current and emerging translational applications.

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In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging

Cited by 56 publications

References 43 publications

Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway

Berberine inhibited carotid atherosclerosis through PI3K/AKTmTOR signaling pathway

IVUS\IVPA hybrid intravascular molecular imaging of angiogenesis in atherosclerotic plaques via RGDfk peptide-targeted nanoprobes

Optoacoustic Imaging in Inflammation

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