<i>In vivo</i> assessment of cytological changes by means of reflectance confocal microscopy – demonstration of the effect of topical vitamin <scp>E</scp> on skin irritation caused by sodium lauryl sulfate

Casari, Alice; Farnetani, Francesca; Pace, Barbara De; Losi, A.; Pittet, Jean Christophe; Pellacani, Giovanni; Longo, Caterina

doi:10.1111/cod.12613

Cited by 11 publications

(7 citation statements)

References 17 publications

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“…Non‐invasive study of skin morphology is of utmost importance to the understanding of the skin's changes in physiological and pathological conditions. Understanding different skin types and conditions, and monitoring changes created by the application of topical products, has become increasingly fundamental in providing scientific validation of product claims in cosmetic science 29–35 …”

Section: Discussionmentioning

confidence: 99%

“…The absence of any damage and alteration of tissue allows for the study of tissue dynamics and the effects of interventions on skin at different times and on cosmetically sensitive areas. Consequently, there has been an increasing use of these imaging modalities in the dermo‐cosmetic field and industry to study skin pathophysiology, to test skin care products and to test the effects of various therapies 29–35 …”

Section: Introductionmentioning

confidence: 99%

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A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

Ciardo

Pezzini

Guida

et al. 2021

Experimental Dermatology

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Non‐invasive reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) have been extended to the dermo‐cosmetic field, for skin pathophysiology understanding and therapeutics monitoring. However, standardized methodology and parameters to interpret structures and changes in these settings are still lacking. Present study aimed to propose a validated standard methodology and a list of defined parameters for objective non‐pathological skin assessments in the cosmetically sensitive cheekbone area of the face. OCT and RCM quantitative, semi‐quantitative and qualitative features were considered for assessments. Validation process included 50 sets of images divided into two age groups. Inter‐rater reliability was explored to assess the influence of the proposed methodology. Quantitative OCT parameters of “epidermal thickness,” “density and attenuation coefficients” and “vascular density” were considered and calculated. Severity scales were developed for semi‐quantitative OCT features of “disruption of collagen” and “vascular asset,” while extent scales were produced for semi‐quantitative RCM “irregular honeycomb,” “mottled pigmentation” and “polycyclic papillary contours.” Qualitative assessment was obtained for RCM type of collagen, and comparison between age groups was performed for all features considered. Severity visual scales assistance proved excellent inter‐rater agreement across all semi‐quantitative and qualitative domains. The assistance of shareable software systems allows for objective OCT quantitative parameters measurement. The use of standard reference scales, within a defined assessment methodology, offers high inter‐rater reliability and thus reproducibility for semi‐quantitative and qualitative OCT and RCM parameters. Taken together, our results may represent a starting point for a standardized application of RCM and OCT in dermo‐cosmetic research and practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

Ciardo

Pezzini

Guida

et al. 2021

Experimental Dermatology

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“…Topical l ‐ascorbic acid, the most biologically active and well‐studied form of vitamin C, is a multifunctional ingredient best known for its preventative antioxidant and photoprotective benefits 1,2 . Vitamin E is a lipophilic antioxidant known for its beneficial effects on the skin, including photoprotection, hydration, and accelerated epithelialization, among others 3 . Evidence suggests that both vitamins C and E protect the skin against UV radiation and may have additive or synergistic protective effects, with a fourfold increase in antioxidant protection factor when used together 4 .…”

Section: Introductionmentioning

confidence: 99%

A serum containing vitamins C & E and a matrix‐repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto‐perception

Lintner

Gerstein²,

Solish

2020

J of Cosmetic Dermatology

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Background Allegations on the benefits of incorporating vitamin C, vitamin E, and combinations thereof in topical skincare formulations are mostly based on in vitro and ex vivo experiments and/or limited protocols of specific stress conditions (pollution, UV exposure, laser irradiation,…). Objective To evaluate the instrumentally measurable effects and quantitative consumer perceptions of a protective and reparative serum on a panel of volunteers under normal nonstressed conditions of use, employing FOITS technology and innovative self‐assessment methods. Method In an open‐label study women of ≥40 years with visible signs of photoaging applied a serum comprising l‐ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide‐38 to the face once daily for 56 days. Skin roughness and isotropy changes were evaluated on days 0, 28, and 56, visual instrumental evaluation of skin‐tone parameters was assessed on days 0 and 56. Subjects completed self‐assessment questionnaires every third day of the trial period for radiance, homogeneity, and wrinkle appearance. Results Skin‐roughness parameters decreased significantly by 8%‐9% (P < .05) and subjects experienced a significant increase in skin isotropy (P < .05). Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles. Conclusion The study confirms statistically significant correlation between objectively measured and quantitative subjectively perceived benefits of the bespoke serum containing antioxidants and a matrix‐restoring peptide.

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“…Interestingly, a peculiar histopathological finding of irritant contact dermatitis, which is the disruption of the stratum corneum with detached corneocytes and parakeratosis, correlated to detached corneocytes in the stratum corneum and targetoid keratinocytes within the stratum granulosum-spinosum with a bright broadened interkeratinocytic border and a central bright spot in RCM. [28][29][30][31]…”

Section: Spongiotic Dermatitismentioning

confidence: 99%

Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review

et al. 2021

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Background/Objectives: Non-invasive skin imaging features of main skin inflammatory and autoimmune diseases have been reported, although a comprehensive review of their correlation with histopathologic features is currently lacking. Therefore, the aim of this paper was to review the correlation of dermoscopic, reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) criteria of main inflammatory and autoimmune skin diseases with their corresponding histopathologic criteria correlation.Conclusions: Although the role of RCM and OCT has yet to be defined in clinical practice, noninvasive skin imaging shows promising results on inflammatory and autoimmune skin diseases, due to the correlation with histopathologic features.

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In vivo assessment of cytological changes by means of reflectance confocal microscopy – demonstration of the effect of topical vitamin E on skin irritation caused by sodium lauryl sulfate

Abstract: Reflectance confocal microscopy is useful in the objective assessment of irritative skin damage.

Cited by 11 publications

References 17 publications

A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

A plea for standardization of confocal microscopy and optical coherence tomography parameters to evaluate physiological and para‐physiological skin conditions in cosmetic science

A serum containing vitamins C & E and a matrix‐repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto‐perception

Dermoscopy, confocal microscopy and optical coherence tomography features of main inflammatory and autoimmune skin diseases: A systematic review

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