In Vivo Assessment of Astrocyte Reactivity in Patients with Progressive Supranuclear Palsy
Kosei Hirata,
Kiwamu Matsuoka,
Kenji Tagai
et al.
Abstract:ObjectiveAlthough astrocytic pathology is a pathological hallmark of progressive supranuclear palsy (PSP), its pathophysiological role remains unclear. This study aimed to assess astrocyte reactivity in vivo in patients with PSP. Furthermore, we investigated alterations in brain lactate levels and their relationship with astrocyte reactivity.MethodsWe included 30 patients with PSP‐Richardson syndrome and 30 healthy controls; in patients, tau deposition was confirmed through 18F‐florzolotau positron emission to… Show more
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