“…FK 3000 is a morphinane type alkaloid having anti-herpes simplex virus activity in vitro and in vivo by inhibiting viral DNA synthesis. [6][7][8] In addition, we found that FK 3000 also had anti-HIV activity (IC 100 ϭ7.8 mg/ml, CC 0 ϭ15.6 mg/ml) but no inhibi-tory activity against HIV-1 PR, suggesting that it targets a stage of the viral life cycle, different from that mediated by PR. When all the conjugates were tested for their anti-HIV activity and PR inhibitory activity, the triterpene-FK 3000 conjugates (2f, 4f, 6f) showed neither inhibitory activity against HIV-1 PR nor anti-HIV activity.…”