In vivoantiplasmodial activities of aqueous extract ofBridelia ferrugineastem bark againstPlasmodium berghei bergheiin mice

Mbah, Chukwuemeka C.; Akuodor, Godwin Christian; Anyalewechi, N A; Iwuanyanwu, T. C.; Osunkwo, U. A.

doi:10.3109/13880209.2011.592537

Cited by 21 publications

(12 citation statements)

References 28 publications

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“…This could be due to recrudescence Key: + = present, -= absent of P. berghei parasites after apparent cure. 21 According to Mbah et al, 22 the curative property of potential antimalarial agents of plantbased origin should be detectable during screening for antimalarial activity. Thus, the ability of the extract to decrease parasitemia levels and prolong survival time suggests that it has antimalarial activity.…”

Section: Resultsmentioning

confidence: 99%

Antimalarial Activity of the Methanol Aerial Extract of Alysicarpus glumaceus (Vahl) DC. in Plasmodium berghei Infected Mice

Olorukooba¹,

Khan²,

Madu³

2019

TJNPR

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Article history:Medicinal plants are a potential source of affordable and effective drugs used in the treatment of many diseases. The plant Alysicarpus glumaceus has been used in traditional medicine for the treatment of many ailments including; thrush, sore, asthma, burn, and fever. The present study was designed to investigate the antimalarial activity of the methanol aerial extract of Alysicarpus glumaceus in Plasmodium berghei infected mice using suppressive, curative and prophylactic models. Phytochemical screening using standard procedures and acute toxicity studies via the oral route in mice were also conducted. Results from the phytochemical screening revealed the presence of glycosides, saponins, tannins, flavonoids, triterpenes, and alkaloids. The oral mean lethal dose (LD50) was estimated to be greater than 5,000 mg/kg in mice. The methanol aerial extract of Alysicarpus glumaceus at doses of 250, 500 and 1,000 mg/kg produced a significant (p<0.05) dose-dependentchemosuppression in the suppressive, curative and prophylactic tests respectively. There was a statistically significantly (p<0.05) prolongation of mean survival time in the extract treated mice in the curative study. The results of this investigation suggest that the methanol aerial extract of Alysicarpus glumaceus contains bioactive constituents with antimalarial activity.

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Section: Resultsmentioning

confidence: 99%

Antimalarial Activity of the Methanol Aerial Extract of Alysicarpus glumaceus (Vahl) DC. in Plasmodium berghei Infected Mice

Olorukooba¹,

Khan²,

Madu³

2019

TJNPR

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“…In vivo antiplasmodial study 9,10,11,12 Suppressive study: This was the four-day suppressive study adopting the methods of Akuodor et al and David et al with slight modification. Thirty healthy albino wistar rats (male or female) were inoculated intraperitoneally with infected blood suspension (0.2 mL) containing 1 × 107 NK65 Plasmodium falcipuram.…”

Section: Infection Of Wistar Rats With Plasmodium Falcipurammentioning

confidence: 99%

Antiplasmodial Activity of Caesalpinia Crista Seed Extracts

Reddy

Kuber²

2018

J. Drug Delivery Ther.

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Objective: To evaluate antiplasmodial activity of Caesalpinia crista seed extracts Methods: Antiplasmodial activity of the seed extracts of Caesalpinia crista against rodent malaria infections in chloroquine sensitive Plasmodium falcipuram strain was investigated, and oral acute toxicity of seed extracts of Caesalpinia crista was also evaluated. Results: The findings of this study revealed significant (P < 0.05) and dose dependent decrease in parasitaemia in the parasitized groups treated with varying doses of the extract (50-200 mg/kg p.o.) in both suppressive and curative tests. There was also significant decrease in parasitaemia density in the chloroquine treated group. The alcoholic extract was found no toxicity in wistar rats and the oral LD50 was determined to be greater than 5000 mg/kg. Conclusion: Seed extracts of Caesalpinia crista extract possesses potent antiplasmodial activity and may therefore, serve as potential sources of new antimalarial agents Keywords: Plasmodium falcipuram, Caesalpinia crista, Plant extracts, Phytochemicals, Toxicity tests, malaria.

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“…The stem bark was extracted by maceration in hot distilled water as previously reported [10]. The bark was cleaned and scales removed.…”

Section: Preparation Of Crude Extractmentioning

confidence: 99%

“…In Nigeria, it is commonly found in the Savannah and other more humid regions of Africa. The aqueous stem bark extract has been reported to demonstrate antiinflammatory, antipyretic and analgesic activities in vivo and in vitro [9] as well as significant antiplasmodial activity against Plasmodium berghei berghei in mice [10].…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Characterization of Aqueous Stem Bark Extract of Bridelia ferruginea Benth (Euphorbiaceae)

Mbah¹,

Builders²,

Akuodor³

et al. 2012

Trop. J. Pharm Res

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In vivoantiplasmodial activities of aqueous extract ofBridelia ferrugineastem bark againstPlasmodium berghei bergheiin mice

Abstract: The findings show that aqueous stem bark extract of Bridelia ferruginea possesses considerable antiplasmodial activity which can be developed in malaria therapy.

Cited by 21 publications

References 28 publications

Antimalarial Activity of the Methanol Aerial Extract of Alysicarpus glumaceus (Vahl) DC. in Plasmodium berghei Infected Mice

Antimalarial Activity of the Methanol Aerial Extract of Alysicarpus glumaceus (Vahl) DC. in Plasmodium berghei Infected Mice

Antiplasmodial Activity of Caesalpinia Crista Seed Extracts

Pharmaceutical Characterization of Aqueous Stem Bark Extract of <i>Bridelia ferruginea</i> Benth (Euphorbiaceae)

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