In vivo Antioxidant and Hepato-Protective Properties of Stem Bark Methanol Extract of Vitex doniana

Abstract

The harmful effects that accompany the use of orthodox antioxidant medicine have necessitated the hunt for inherent antioxidants from plants extracts. In the present study, the in vivo antioxidant and hepato-protective activities of Vitex doniana against carbon tetrachloride (CCl4) induced liver damage in albino rats were investigated. The hepato-protective activities of the methanol extract of Vitex doniana stem bark were compared with Silymarin, a known hepatoprotective drug. Twenty-five (25) male albino adult rats were grouped into five (5) each. Group 1 and 2 was used as the normal and negative control respectively. Group 3-5 were treated with 200 mg/kg, 400 mg/kg methanol extract of Vitex doniana stem bark and 100 mg/kg Silymarin respectively. Results indicated that elevated levels of serum ALT, AST and ALB, and reduced serum SOD, GST and CAT in CCl4-hepatotoxic rats was an evidence of impairment in liver function. Administration of methanol extract of Vitex doniana stem bark (200 and 400 mg/kg body weight) and standard control drug Silymarin (100 mg/kg) have no significant (P>0.05) effect on CCl4- induced elevations of the ALT and AST levels while the reduction in albumin concentration, total proteins, SOD, GST and CAT due to CCl4 was reversed. In conclusion, Vitex doniana exhibited significant antioxidant and hepatoprotective properties in CCL4 induced liver damage in rat, and thus could be used and incorporated in the development of new and effective antioxidant drugs.

Remote Sensing and in-Situ-Based Assessment of Greenhouse Gases in Nigeria

“…This is more so with the very limited information available with respect to the subject matter. In recent years, there has been the development of greenhouse gases observing satellites which are a technology deployed to 142 aid effective monitoring of greenhouse gas emissions (Lawal et al, 2023) This explains why utilizing satellite data to estimate a flux of greenhouse gas in the atmosphere has become a trending issue (Platonova & Klimova, 2021). Apart from the cost implications of this endeavour, it portends to be a reliable source of ascertaining the quantity of greenhouse gases emissions.…”