In vivoandin vitroanalysis of the role of the Prc protease in inducing mucoidy inPseudomonas aeruginosa
Alexis G. Sommerfield,
Michelle Wang,
Julia Mamana
et al.
Abstract:InPseudomonas aeruginosa,alginate biosynthesis gene expression is inhibited by the transmembrane anti-sigma factor MucA, which sequesters the AlgU sigma factor. Cell envelope stress initiates cleavage of the MucA periplasmic domain by site-1 protease AlgW, followed by further MucA degradation to release AlgU. However, after colonizing the lungs of people with cystic fibrosis,P. aeruginosaconverts to a mucoid form that produces alginate constitutively. Mucoid isolates often havemucAmutations, with the most comm… Show more
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