<i>In vivo</i> and <i>in vitro</i> approaches in understanding the differences between Caucasian and African skin types: specific involvement of the papillary dermis

Girardeau‐Hubert, Sarah; Piégay, Hervé; Asselineau, Daniel

doi:10.1111/j.1365-4632.2012.05553.x

Cited by 21 publications

(21 citation statements)

References 11 publications

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“…16,23 However, currently there is no consensus regarding dermal ECM composition in these different groups. Furthermore, the dermal ECM of both Eurasian and Far East Asian skin is relatively deficient in fibrillar collagens I and III.…”

Section: Discussionmentioning

confidence: 99%

“…Previous comparative studies have focused on the differences between Eurasian and African skin types only, and our data on epidermal morphometrics and collagen VII distribution at the DEJ are consistent with their findings. 16,23 However, currently there is no consensus regarding dermal ECM composition in these different groups. Previous studies have employed disparate methods to characterize the histology of Eurasian and African skin using biopsies of photoprotected and photoexposed skin from young and old participants, resulting in poorly controlled datasets.…”

Section: Discussionmentioning

confidence: 99%

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Geographical ancestry is a key determinant of epidermal morphology and dermal composition

et al. 2014

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We demonstrate that fundamental differences exist in skin structure and composition in individuals of diverse geographical ancestry. Disparate environmental pressures encountered by ancestral human populations living at different latitudes may have driven adaptations in skin structure and composition. Further research into the functional significance and clinical consequences of these differences is warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Geographical ancestry is a key determinant of epidermal morphology and dermal composition

et al. 2014

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“…These studies have identified differences in epidermal thickness and morphology, dermoepidermal junction (DEJ) interdigitation and dermal ECM composition. [15][16][17] While these comparisons help to define histology of healthy skin, they provide no functional information on its biomechanical behaviour. Previous attempts to characterize skin biomechanics in black African and white Northern European cohorts have been largely inconclusive due to contradictory findings between different studies.…”

Section: What Does This Study Add?mentioning

confidence: 99%

“…Recent comparative studies of young, photoprotected skin from black African and white Northern European cohorts have attempted to understand at the histological level what are considered to be the defining characteristics of ‘healthy skin’ in these diverse cohorts. These studies have identified differences in epidermal thickness and morphology, dermoepidermal junction (DEJ) interdigitation and dermal ECM composition …”

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confidence: 99%

Organization of the dermal matrix impacts the biomechanical properties of skin

et al. 2017

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Summary Background Human skin has the crucial roles of maintaining homeostasis and protecting against the external environment. Skin offers protection against mechanical trauma due to the reversible deformation of its structure; these biomechanical properties are amenable to dynamic testing using noninvasive devices. Objectives To characterize the biomechanical properties of young, black African/African‐Caribbean and white Northern European skin from different anatomical sites, and to relate underlying skin architecture to biomechanical function. Methods Using cutometry and ballistometry, the biomechanical properties of buttock and dorsal forearm skin were determined in black African/African‐Caribbean (n = 18) and white Northern European (n = 20) individuals aged 18–30 years. Skin biopsies were obtained from a subset of the volunteers (black African/African‐Caribbean, n = 5; white Northern European, n = 6) and processed for histological and immunohistochemical detection of the major elastic fibre components and fibrillar collagens. Results We have determined that healthy skin from young African and white Northern European individuals has similar biomechanical properties (F3): the skin is resilient (capable of returning to its original position following deformation, R1), exhibits minimal fatigue (R4) and is highly elastic (R2, R5 and R7). At the histological level, skin with these biomechanical properties is imbued with strong interdigitation of the rete ridges at the dermoepidermal junction (DEJ) and candelabra‐like arrays of elastic fibres throughout the papillary dermis. Dramatic disruption to this highly organized arrangement of elastic fibres, effacement of the rete ridges and alterations to the alignment of the fibrillar collagens is apparent in the white Northern European forearm and coincides with a marked decline in biomechanical function. Conclusions Maintenance of skin architecture – both epidermal morphology and elastic fibre arrangement – is essential for optimal skin biomechanical properties. Disruption to underlying skin architecture, as observed in the young white Northern European forearm, compromises biomechanical function.

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“…Comparative studies of young black and white individuals have attempted to understand at the histologic level what is considered to be the defining characteristics of healthy skin. Such studies have identified differences in epidermal thickness and morphology, DEJ interdigitation and dermal extracellular matrix (ECM) composition (Girardeau et al, 2009;Girardeau-Hubert et al, 2012;Langton et al, 2014). Skin biomechanical function has also been assessed in diverse cohorts and identified that skin architecture-both epidermal morphology and elastic fiber arrangement-are essential for providing skin's optimal biomechanical properties (Langton et al, 2017b).…”

Section: Introductionmentioning

confidence: 99%

Aging in Skin of Color: Disruption to Elastic Fiber Organization Is Detrimental to Skin’s Biomechanical Function

Langton

Alessi

Hann

et al. 2019

Journal of Investigative Dermatology

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Skin aging is a complex process involving the additive effects of time-dependent intrinsic aging and changes elicited via skin's interaction with the environment. Maintaining optimal skin function is essential for healthy aging across global populations; yet most research focuses on lightly pigmented skin (Fitzpatrick phototypes IeIII), with little emphasis on skin of color (Fitzpatrick phototypes VeVI). Here, we explore the biomechanical and histologic consequences of aging in black African-American volunteers. We found that healthy young buttock and dorsal forearm skin was biomechanically resilient, highly elastic, and characterized histologically by strong interdigitation of rete ridges, abundant organized fibrillar collagen, and plentiful arrays of elastic fibers. In contrast, intrinsically aged buttock skin was significantly less resilient, less elastic, and was accompanied by effacement of rete ridges with reduced deposition of both elastic fibers and fibrillar collagens. In chronically photoexposed dorsal forearm, significant impairment of all biomechanical functions was identified, with complete flattening of rete ridges and marked depletion of elastic fibers and fibrillar collagens. We conclude that in skin of color, both intrinsic aging and photoaging significantly impact skin function and composition, despite the additional photoprotective properties of increased melanin. Improved public health advice regarding the consequences of chronic photoexposure and the importance of multimodal photoprotection use for all is of global significance.

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In vivo and in vitro approaches in understanding the differences between Caucasian and African skin types: specific involvement of the papillary dermis

Abstract: Background Most of the identified differences between Caucasian and African skin types

Cited by 21 publications

References 11 publications

Geographical ancestry is a key determinant of epidermal morphology and dermal composition

Geographical ancestry is a key determinant of epidermal morphology and dermal composition

Organization of the dermal matrix impacts the biomechanical properties of skin

Aging in Skin of Color: Disruption to Elastic Fiber Organization Is Detrimental to Skin’s Biomechanical Function

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