<i>In Vitro – In Vivo</i> Evaluation of Antiurolithiatic activity of piperine from <i>Piper nigrum</i>

Suvarna, Yenduri; Rahaman, Sohanur

doi:10.5958/0974-360x.2020.00011.6

Cited by 10 publications

(6 citation statements)

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“…Several studies [43][44][45][46][47][48] have reported, in vitro, the effect of hydroxyanthraquinones, sulfated polysaccharides, L-arginine, vitamin E, DADS, DATS, betulin, and piperin on the prevention of nephrolithiasis formation using the crystallization process in human urine, titrimetric, conductometric titration, and crystal development in cell culture assays.…”

Section: In Vitro Investigationsmentioning

confidence: 99%

“…Recently, [48] evaluated, in vitro, the effect of piperine at different concentrations (10 and 20 mg/kg) using the titrimetric method and aggregation assay. At 20 mg/kg, piperine significantly inhibited the crystallization than piperine at 10 mg/kg compared to cystone (standard drug).…”

Section: In Vitro Investigationsmentioning

confidence: 99%

“…The nephrolithiasis effect of the in vivo approach of taraxasterol, betulin, lupeol, khellin, visnagin, crocin, piperine, berberine, oleanolic acid, vitamin E, selenium, DADS, DATS, and rottlerin (Figure 5) was investigated by several researchers (Table 4) using several animal models, including oral administration of EG, EG with ammonium chloride, pyridoxine-deficient diet (PDD), or using the implantation of a foreign body (zing disc and glass bead) to mimic the etiology of urinary stone formation in humans [24,46,[48][49][50][51][52][53][54][55][56][57][58][59][60].…”

Section: In Vivo Investigationsmentioning

confidence: 99%

“…The prophylactic and curative effect of crocin, the main water-soluble carotenoid of Crocus sativus, was evaluated by [59] at different concentrations (10, 20, and 40 mg/kg/day) in urolithiasis rats. In the Furthermore, two authors evaluated, in vivo, the effect of two alkaloids (berberine and piperine) on CaOx urolithiasis in rats [48,56]. Bashir et al [56] evaluated the preventive and curative effects of berberine.…”

Section: In Vivo Investigationsmentioning

confidence: 99%

“…These findings suggest that khellin nephrolithiasis activity is mediated by a combination of antioxidant, diuretic, hypocalciuric, and urinealkalinizing activities. Recently, Suvarna et al [48] have evaluated, in vivo, the urolithiasis effect of piperine against hyperoxaluria induced in Wistar rats. The results showed that this alkaloid ameliorated the serum parameters (calcium, urea, uric acid, and creatinine) and urine parameters (calcium and oxalate) [48].…”

Section: In Vivo Investigationsmentioning

confidence: 99%

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Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

et al. 2021

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Urolithiasis is a disease characterized by the formation of stones, which are crystalline accretions that form in the urinary tract from minerals dissolved in the urine. Moreover, it is considered to be a complex and multifactorial disease, requiring treatment. Unfortunately, current treatments are insufficient or may induce several side effects. In fact, medicinal plants are among the anti-litholytic treatments that are strongly recommended by many studies. Indeed, these natural resources contain bioactive molecules of different natures, such as flavonoids, terpenoids, alkaloids, and phenolic acids, which have recently demonstrated very important anti-litholytic effects. The molecular mechanisms involved are multiple and variable, and can reach cellular and molecular levels. In this review, we have discussed in depth the work that has studied the bioactive molecules of medicinal plants and their major potential against urolithiasis. Scientific databases, including Web of Science, PubMed, and Google Scholar, were searched from their inception until April 2021.The cellular and molecular mechanisms are presented and discussed. Some mechanisms of action related to these bioactive compounds are highlighted. This review could provide a scientific starting point for further studies on urolithiasis and natural bioactive compounds, especially flavonoids.

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Section: In Vitro Investigationsmentioning

confidence: 99%

Section: In Vitro Investigationsmentioning

confidence: 99%

Section: In Vivo Investigationsmentioning

confidence: 99%

Section: In Vivo Investigationsmentioning

confidence: 99%

Section: In Vivo Investigationsmentioning

confidence: 99%

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Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

et al. 2021

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Synthesis, characterization, and molecular docking studies of novel hippuric acid anhydrides as potential antiurolithic, analgesic and free radical scavenging agents

Munawar,

ur Rehman Khan,

Nadeem

et al. 2024

Journal of Saudi Chemical Society

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Determination of Ocular Irritancy Potential of Ophthalmic products using HET-CAM Method

2021

RJPT

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Objective: The research is about the stability of ophthalmic products as they start to produce irritancy effects during their shelf life. The aim of the present study is to assess the stability of certain ophthalmic products by the HET-CAM (Hen’s Egg Test-Chorioallatonic membrane) Method. Method: Incubated Eggs were utilized for performing the HET-CAM assay according to the protocol prescribed by ICCVAM (The Inter agency Coordinating Committee on the Validation of Alternative Methods). Results: Calculation of various irritancy factors like hemorrhage time, vascular lysis time and coagulation time and to calculate HET-CAM score. Statistical interpretation of the data obtained by one-way ANOVA. Conclusion: Results have shown that the few ophthalmic products are slight and moderate irritants. None of the products are strong irritants. However further studies to be conducted to confirm the potential and safety of the products.

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In Vitro – In Vivo Evaluation of Antiurolithiatic activity of piperine from Piper nigrum

Cited by 10 publications

References 0 publications

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

Litholytic Activities of Natural Bioactive Compounds and Their Mechanism Insights

Synthesis, characterization, and molecular docking studies of novel hippuric acid anhydrides as potential antiurolithic, analgesic and free radical scavenging agents

Determination of Ocular Irritancy Potential of Ophthalmic products using HET-CAM Method

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