The CEF Panel of the European Food Safety Authority was requested to evaluate 80 flavouring substances in the Flavouring Group Evaluation 08, Revision 4, using the Procedure in Commission Regulation (EC) No 1565/2000. Since the publication of the last revision of this FGE, the EFSA has been requested to evaluate additional toxicological data submitted for two flavouring substances, one substance 2,5-dihydroxy-2,5-dimethyl-1,4-dithiane .006], which support the evaluation of the candidate substance 2,5-dihydroxy-1,4-dithiane .134] and one on the candidate substance spiro(2,4-dithia-1-methyl-8-oxabicyclo[3.3.0]octane-3,3'-(1'-oxa-2'-methyl)-cyclopentane) and spiro(2,4-dithia-6-methyl-7-oxabicyclo[3.3.0]octane-3,3'-(1'-oxa-2'-methyl)-cyclopentane) .007], which have been included in the present revision of FGE.08. For the substances methyl methanethiosulphonate ], 2-methylbutane-2-thiol ], 2-methylpropane-2-thiol .174], ethyl-2-mercapto-2-methyl propanoate .304] and 2,4,4-trimethyl-1,3-oxathiane there is an indication of a genotoxic potential in vitro. Therefore, without further genotoxicity data, the Panel concluded that the Procedure could not be applied to these five substances. For four substances, 3-mercaptooctanal 4 Editorial changes have been made on pages 1 and 2. The changes do not affect the overall conclusions of the opinion. To avoid confusion, the original version of the Opinion has been removed from the website, but it is available on request.Flavouring Group Evaluation 08, Revision 5EFSA Journal 2012;10(7):2837 2 one ] no data on use as flavouring substances in Europe are available and no intake figures could be calculated, which preclude the evaluation of the four substances using the Procedure. The remaining 71 substances were evaluated through a stepwise approach that integrates information on the structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that 59 substances do not rise safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. For 12 substances 12.094, 12.097, 12.100, 12.112, 12.116, 12.120, 12.164, 12.167, 12.199, 15.102 and 15.125 no: 15.007] has been reconsidered after submission of an explanatory note from EFFA.Additional information on specifications and/or stereoisomeric/positional composition submitted for 12.163, 12.164, 12.250, 12.266, 12.277, 12.278, 12.298, 12.300, 12.301, 12.302, 12.305, 12.306, 15.007, 15.056, 15.110, 15.134, 16.062, 16.114 and 16.122] has also been included.The present FGE.08Rev5 deals with 80 flavouring substances in total. These are divided into 11 subgroups:Subgroup I) Acyclic sulphides: 12.099, 12.117, 12.124, 12.127, 12.129, 12.152, 12.158, 12.163, 12.166, 12.177, 12.178, 12.181, 12.182, 12.183, 12.214, 12.277, 12.298, 12.299 and 12.306] Subgroup II) Cyclic sulphides: 15.102 and 15.125] Subgroup III) Monothiols: 12.135, 12.136, 12.172, 12.174, 12.180, 12.191, 12.205, 12.250, 12.2...