In vitro susceptibility of dermatophytes isolated from patients with end‐stage renal disease: a case–control study

Abstract

Although the therapeutic efficacy of antifungals is well known for dermatophytosis in general population, limited data exist for patients with chronic kidney disease. The objectives of this study were to determine the dermatophyte species causing infection in patients with end-stage renal disease (ESRD) and in vitro susceptibility of isolated dermatophytes to antifungals. A total of 87 patients with ESRD who undergoing haemodialysis and 105 patients with normal renal function suspected with dermatophytosis were included. Skin scrapings or nail clippings were examined by direct microscopy and cultured on Sabouraud agar. In vitro antifungal susceptibility tests were performed using a broth microdilution method. Dermatophyte infections were identified in 32.2% of haemodialysis patients and in 29.5% of controls (P > 0.05). In both groups, Trichophyton rubrum was the most frequently isolated. Mean MIC values of the all studied antifungals for all of isolated dermatophyte strains from patients with ESRD were similar to those obtained in control group (P > 0.05). Terbinafine (TBF) had the lowest mean MIC values for all tested dermatophytes in both groups. We consider that TBF should be the treatment of choice for dermatophytosis in patients with chronic kidney disease, but the dose should be adjusted according to creatinine clearance and should be monitored for side effects.

Prevalence and epidemiology of tinea pedis and toenail onychomycosis and antifungal susceptibility of the causative agents in patients with type 2 diabetes in Turkey

“…have been reported as representing the most common yeast pathogen of onychomycosis in several In dermatophytosis, systemic treatment is generally considered to be the most successful approach; the management of dermatophytic skin and nail infections in diabetes patients is based on oral antifungal therapy. 17,23,24 The present study also identified TRB as having the lowest and FLU had the highest MIC values for all dermatophyte strains tested. 21 A Cochrane review revealed that TRB was significantly more effective in tinea pedis than griseofulvin, and TRB and ITRA were more effective than placebo.…”

“…22 Similarly, in vitro studies revealed that TRB had the lowest and FLU had the highest MIC values against dermatophytes. 17,23,24 The present study also identified TRB as having the lowest and FLU had the highest MIC values for all dermatophyte strains tested.…”

Dermatophytes and Dermatophytosis in Cluj-Napoca, Romania—A 4-Year Cross-Sectional Study

“…During recent decades, insufficient studies have been performed and published regarding the ecology, epidemiology, and etiology of dermatophytosis in Romania. Very little information is available about the etiology of superficial fungal infections in Romania: several old studies, performed between 1968 and 1973 in Bucharest (South-Eastern Romania) [ 14 , 15 , 16 ], and only one relatively recent study [ 17 ], published in 2015, concerning the area of Brasov, in Central Romania.…”

In vitro activities of 15 antifungal drugs against a large collection of clinical isolates of Microsporum canis

“…12 M. canis is among the best-known agents of human tinea capitis, tinea corporis and tinea manum in different geographical areas; however, it has been rarely associated with tinea unguium and tinea faciei. [13][14][15] Previous studies have documented low in vitro susceptibility towards fluconazole, itraconazole, ketoconazole, terbinafine, naftifine, griseofulvin and ciclopirox [16][17][18] ; clinical isolates of T rubrum and T interdigitale that are resistant to allylamines, particularly terbinafine, with point mutations in the squalene epoxidase-encoding gene, have also been reported. [19][20][21] Owing to problems with molecular identification, the distinction between the anthropophilic T interdigitale and zoophilic T mentagrophytes leads to some taxonomical confusion.…”