<i>In vitro</i>study on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes

Ji, Xiaofei; Ding, Baodong; Wu, Xiaoyou; Liu, Fengyi; Yang, Fengqi

doi:10.1080/00498254.2020.1842941

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…CYP450s have also been considered the major mediator of herb-herb interactions. Cryptotanshinone was metabolized by CYP3A4, which was demonstrated to be inhibited by ophiopogonin D in a concentration-dependent with the IC50 value of 8.08 μM (Ji et al, 2021;Zeng et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…CYP450s have also been considered the major mediator of herb‐herb interactions. Cryptotanshinone was metabolized by CYP3A4, which was demonstrated to be inhibited by ophiopogonin D in a concentration‐dependent with the IC50 value of 8.08 μM (Ji et al, 2021; Zeng et al, 2018). Although the experimental concentration of ophiopogonin D in the present study is much lower than the reported IC50 value, the inhibitory effect of ophiopogonin D on the activity of CYP3A4 might occur, which would mediate the interaction during the co‐administration.…”

Section: Discussionmentioning

confidence: 99%

“…In previous studies, cytochrome P450 enzymes (CYP450s) were considered the main factor mediating herb‐herb or drug–drug interactions. Ophiopogonin D has been demonstrated to inhibit the activity of CYP3A4, 2C9, and 2E1 in an in vitro study (Ji et al, 2021). The metabolism of cryptotanshinone was characterized as mediated by CYP3A4, 1A2, and 2C19 (Zeng et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Effect of ophiopogonin D on the pharmacokinetics and transport of cryptotanshinone during their co‐administration and the potential mechanism

Wang

Chen

2023

Chem Biol Drug Des

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Cryptotanshinone and ophiopogonin D are sourced from herbs with similar indications. It is necessary to evaluate their interaction to provide a reference for their clinical prescriptions. The co‐administration of cryptotanshinone (30 and 60 mg/kg) and ophiopogonin D was carried out in Sprague–Dawley rats and the pharmacokinetics of cryptotanshinone were analyzed. The Caco‐2 cells were employed to evaluate the transport of cryptotanshinone, and the metabolic stability was studied in the rat liver microsomes. Ophiopogonin D significantly increased the Cmax (from 5.56 ± 0.26 to 8.58 ± 0.71 μg/mL and from 15.99 ± 1.81 to 185.12 ± 1.43 μg/mL), half‐life (21.72 ± 10.63 vs. 11.47 ± 3.62 h and 12.58 ± 5.97 vs. 8.75 ± 2.71 h) and decreased the clearance rate (0.697 ± 0.36 vs. 1.71 ± 0.15 L/h/kg) and (60 mg/kg and 0.101 ± 0.02 vs. 0.165 ± 0.05 L/h/kg) of cryptotanshinone. In vitro, ophiopogonin D significantly suppressed the transport of cryptotanshinone with the decreasing efflux rate and enhanced the metabolic stability with the reducing intrinsic clearance. The combination of cryptotanshinone and ophiopogonin D induced prolonged exposure and suppressed the transport of cryptotanshinone, which indicated the decreased bioavailability of cryptotanshinone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effect of ophiopogonin D on the pharmacokinetics and transport of cryptotanshinone during their co‐administration and the potential mechanism

Wang

Chen

2023

Chem Biol Drug Des

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4-O-galloylalbiflorin inhibits the activity of CYP3A, 2C9, and 2D in human liver microsomes

Sun

et al. 2021

Xenobiotica

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Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

Cheng

2021

IJMS

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Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection; the pathophysiology of sepsis is complex. The incidence of sepsis is steadily increasing, with worldwide mortality ranging between 30% and 50%. Current treatment approaches mainly rely on the timely and appropriate administration of antimicrobials and supportive therapies, but the search for pharmacotherapies modulating the host response has been unsuccessful. Chinese herbal medicines, i.e., Chinese patent medicines, Chinese herbal prescriptions, and single Chinese herbs, play an important role in the treatment of sepsis through multicomponent, multipathway, and multitargeting abilities and have been officially recommended for the management of COVID-19. Chinese herbal medicines have therapeutic actions promising for the treatment of sepsis; basic scientific research on these medicines is increasing. However, the material bases of most Chinese herbal medicines and their underlying mechanisms of action have not yet been fully elucidated. This review summarizes the current studies of Chinese herbal medicines used for the treatment of sepsis in terms of clinical efficacy and safety, pharmacological activity, phytochemistry, bioactive constituents, mechanisms of action, and pharmacokinetics, to provide an important foundation for clarifying the pathogenesis of sepsis and developing novel antisepsis drugs based on Chinese herbal medicines.

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In vitrostudy on the effect of ophiopogonin D on the activity of cytochrome P450 enzymes

Cited by 3 publications

References 31 publications

Effect of ophiopogonin D on the pharmacokinetics and transport of cryptotanshinone during their co‐administration and the potential mechanism

Effect of ophiopogonin D on the pharmacokinetics and transport of cryptotanshinone during their co‐administration and the potential mechanism

4-O-galloylalbiflorin inhibits the activity of CYP3A, 2C9, and 2D in human liver microsomes

Research Progress in Chinese Herbal Medicines for Treatment of Sepsis: Pharmacological Action, Phytochemistry, and Pharmacokinetics

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