In vitro study of drug loading on polymer‐free oxide films of metallic implants

Abstract

Traditionally, a drug that is loaded onto a metallic surface has to use various polymer bondings as its platform. Unfortunately, polymer coatings on a metallic surface cause numerous problems after implantation, such as late thrombosis, inflammation, and restenosis. This research was conducted to investigate whether an oxide layer can be used as a polymer-free platform for drug loading, especially for cardiovascular stents. The interaction and loading of heparin onto different oxide films on 316LVM stainless steel wire was confirmed in vitro by experimental studies using linear voltammetry, electrochemical impedance spectroscopy, and electron spectroscopy for chemical analysis. The eluting of heparin from heparinized surface was studied by using high-performance liquid chromatography, and activated clotting time in addition to linear voltammetry and electron spectroscopy for chemical analysis analyses. Experimental results show that amorphous oxide could be a potential substitute for the polymer coating of drug-loaded stents for minimizing metallic corrosion, inflammation, late thrombosis, and restenosis.

High‐Z Nanostructured Ceramics in Radiotherapy: First Evidence of Ta2O5‐Induced Dose Enhancement on Radioresistant Cancer Cells in an MV Photon Field

“…Tantalum metal has a relatively high atomic number ( Z = 73), which is advantageous for dose enhancement; is a known biocompatible material, having been used in orthopedic surgery and consequently, is non‐toxic to healthy cells. Furthermore, its combination with oxygen is based on the notion that the oxide may provide a linkage for the NSP to be functionalized and made to target tumor cells . TaO x NPs have been created and functionalized through PEGylation, a technique that improves biocompatibility and antifouling activity.…”

Mechanism of degradation of AgCL coating on biopotential sensors

“…14,15 Variation of resistance and phase angle was observed for the new and used EKG electrodes indicating the inconsistent properties of the AgCl coatings. These inconsistent properties could be originated from the inconsistent thickness of AgCl on EKG electrode, degradation of AgCl coating during exposure to sweat, and/or the presence of nonuniform AgCl coatings on EKG electrodes.…”

A mathematical model for predicting drug release from a biodurable drug‐eluting stent coating

“…The porcine stented arterial segments were excised at different time points, and the amount of residual drug on the stent was measured using high‐performance liquid chromatography technique. The description of this technique, which is very commonly used to determine release rates of drugs from stent coatings,20–22 is not discussed here. The residual amount of drug in the stent coating at a particular time point is subtracted from the total amount of drug in the stent at time t = 0 to determine the amount of drug released from the stent till that time point.…”