In vitro retardation and modulation of human insulin amyloid fibrillation by Fe³⁺ and Cu²⁺ ions

Abstract

Metal ions of the later part of the first-row transition series (Fe, Co, Ni, Cu, and Zn) can form bonds through the carboxylate, hydroxyl, thiol, and imidazole side chains of...

Cu(II) Specifically Disassembles Insulin Amyloid Nanostructures via Direct Interaction with Cross-β Fibrils

“…24,25 For example, Fe(III)-and Ni(II)-based complexes have shown inhibitory effect on insulin fibrillation. 25,26 Insulin hormone is an important supplement for type II diabetic patients; 27 however, there is also a growing concern regarding the amyloid related health risks due to insulin aggregation in the syringe vials and formation of amyloid structures at the site of repeated insulin injection. 28,29 The imbalance in the level of Cu(II) ions causes diabetic-linked complications, and studies have confirmed increased diabetic cases due to Cu(II) deficiency.…”

“…Hence, in this study, we examined the antiamyloid effect of Cu(II) on insulin. Recent studies have indicated that different metal ions have shown their affinity for insulin which can influence the conformational and aggregation properties of insulin. , For example, Fe(III)- and Ni(II)-based complexes have shown inhibitory effect on insulin fibrillation. , Insulin hormone is an important supplement for type II diabetic patients; however, there is also a growing concern regarding the amyloid related health risks due to insulin aggregation in the syringe vials and formation of amyloid structures at the site of repeated insulin injection. , The imbalance in the level of Cu(II) ions causes diabetic-linked complications, and studies have confirmed increased diabetic cases due to Cu(II) deficiency. , …”