<i>In vitro</i>production of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene

Pravica, Vera; Asderakis, Argiris; Perrey, Chris; Hajeer, Ali H.; Sinnott, Paul J.; Hutchinson, Ian V.

doi:10.1046/j.1365-2370.1999.00122.x

Cited by 424 publications

(326 citation statements)

References 13 publications

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“…Two a chains and a b chain (from a gene on chromosome 21) are required for functional activity of the receptor, eg induction by IFNg of class II antigens and activation of macrophage bactericidal and tumoricidal effects. Among the IFNg polymorphisms, Pravica et al 25 have shown that the level of INFg expressed from PBMC stimulated with mitogens varies with microsatellite allele genotype, homozygous (2/2) subject being the highest producers.…”

Section: Discussionmentioning

confidence: 99%

Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome

Helbig¹,

Heatley

Harris³

et al. 2003

Genes Immun

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Acute primary Q fever is followed by various chronic sequelae. These include subacute Q fever endocarditis, granulomatous reactions in various organs or a prolonged debilitating post-infection fatigue syndrome (QFS). The causative organism, Coxiella burnetii, persists after an initial infection. The differing chronic outcomes may reflect variations within cytokine and accessory immune control genes which affect regulation of the level of persistence. As a preliminary test of the concept we have genotyped QFS patients and controls for gene variants spanning 15 genes and also examined HLA-B and DR frequencies. QFS patients exhibited a significantly increased frequency of HLA-DR-11 compared with controls and also significant differences in allelic variant frequencies within the NRAMP, and IFNg genes. These results indicate a possible genetic role in the expression of overt chronic Q fever. Further studies will be undertaken to increase sample sizes, to survey other forms of chronic Q fever and to examine Q fever patients who have recovered without sequelae.

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Section: Discussionmentioning

confidence: 99%

Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome

Helbig¹,

Heatley

Harris³

et al. 2003

Genes Immun

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“…Several regulatory genetic elements associated with differences in secretion have recently been identified in the genes coding for a number of different cytokines. [1][2][3][4][5][6] These regulatory polymorphisms are therefore thought to be at least partially responsible for interindividual differences in their ability to cope with a given challenge to the immune system. Different cytokine genotypes directly reflect high-and low-responsive cytokine promoters.…”

Section: Introductionmentioning

confidence: 99%

Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used

et al. 2004

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“…1,2 Several studies have reported associations between IFNG polymorphisms and susceptibility to disease. The first intron of the IFNG gene contains a highly polymorphic CA-repeat microsatellite, whose 12 CA-repeat allele is associated with high levels of IFNg production in vitro 3 and has been associated with resistance or susceptibility to various diseases including rheumatoid arthritis, 4 allograft fibrosis in lung transplant recipients, 5 acute graft-versus-host disease 6 and asthma. 7 This microsatellite allele has been associated with a singlenucleotide polymorphism (SNP) allele IFNG þ 874T, which coincides with a putative NF-kB binding site, 8 and has been associated with resistance to tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region

et al. 2005

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Interferon-gamma, encoded by IFNG, is a key immunological mediator that is believed to play both a protective and a pathological role in malaria. Here, we investigate the relationship between IFNG variation and susceptibility to malaria. We began by analysing West African and European haplotype structure and patterns of linkage disequilibrium across a 100 kb genomic region encompassing IFNG and its immediate neighbours IL22 and IL26. A large case-control study of severe malaria in a West Africa population identified several weak associations with individual single-nucleotide polymorphisms in the IFNG and IL22 genes, and defined two IL22 haplotypes that are, respectively, associated with resistance and susceptibility. These data provide a starting point for functional and genetic analysis of the IFNG genomic region in malaria and other infectious and inflammatory conditions affecting African populations.

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In vitroproduction of IFN-γ correlates with CA repeat polymorphism in the human IFN-γ gene

Cited by 424 publications

References 13 publications

Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome

Variation in immune response genes and chronic Q fever. Concepts: preliminary test with post-Q fever fatigue syndrome

Mosaics of gene variations in the Interleukin-10 gene promoter affect interleukin-10 production depending on the stimulation used

Investigation of malaria susceptibility determinants in the IFNG/IL26/IL22 genomic region

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