<i>In Vitro</i>Permeation Study of Hinokitiol: Effects of Vehicles and Enhancers

Joo, Hyang Hee; Kim, Jin‐Chul; Lee, Hyeon Yong

doi:10.1080/10717540701827626

Cited by 6 publications

(2 citation statements)

References 14 publications

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“…18) These results suggest that the binary SCL system could enhance stability compared with the SCL of single compound similar to glassy co-amorphous systems. 11,12,19) Therefore KET-ETH (2 : 1) SCL was selected and evaluated as a suitable formulation from the viewpoint of physical stability.…”

Section: Crystal Form Of Scls After Recrystallization Induced By Stimmentioning

confidence: 99%

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A Novel Binary Supercooled Liquid Formulation for Transdermal Drug Delivery

Hirakawa

Ueda

Wakabayashi

et al. 2020

Biological & Pharmaceutical Bulletin

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The aim of this study was to prepare binary supercooled liquid (SCL) by intermolecular interaction and apply this formulation to transdermal drug delivery. Ketoprofen (KET) and ethenzamide (ETH) were selected as binary SCL component. Thermal analysis of physical mixtures of KET and ETH showed decreases in melting points and glass transition below room temperature, thereby indicating formation of KET-ETH SCL. Intermolecular interactions between KET and ETH in the SCL were evaluated from Fourier transform (FT)-IR spectra. KET-ETH SCL maintained SCL state at 25°C with silica gel over 31 d and at 40°C/89% relative humidity (RH) over 7 d. KET SCL and KET-ETH SCL showed similar permeability of KET for hairless mice skin, which was twofold higher than that of KET aqueous suspension. Our findings suggest that the SCL state could enhance the skin permeation of drugs and the binary SCL formed by intermolecular interaction could also improve the stability of the SCL. The binary SCL system could become a new drug form for transdermal drug delivery.

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Section: Crystal Form Of Scls After Recrystallization Induced By Stimmentioning

confidence: 99%

“…9,10) Several researchers have shown that a co-amorphous system improved stability of the amorphous state compared with that of single compound. 11,12) Hence SCL based on the co-amorphous approach, which stabilizes the thermodynamically unstable state by intermolecular interactions, should also improve the stability of the SCL state.…”

Section: Introductionmentioning

confidence: 99%