In vitroovicidal and larvicidal activities of aqueous and ethanolic extracts of stem bark ofNauclea latifolia(Rubiaceae) onHeligmosomoides bakeri(Nematoda, Heligmosomatidae)

Josué, Wabo Pone; Payne, VK; Alidou, M. Ngangout; Claire, Komtangi Marie; Jeannette, Yondo; Gertrude, Mbogning Tayo; Mbida, Mpoame; Bilong, Charles Félix Bilong

doi:10.5958/j.0975-4261.4.4.034

Cited by 3 publications

(2 citation statements)

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“…Ethanol extracts were obtained using the procedure described by Josué et al [ 13 ]. Briefly, 100 g of stored powder was macerated in 1.5 L of 95% (v/v) ethanol for 72 hours with occasional stirring.…”

Section: Methodsmentioning

confidence: 99%

Antimalarial and Antioxidant Activities of Ethanolic Stem Bark Extract of Terminalia macroptera in Swiss Albino Mice Infected with Plasmodium berghei

Sidiki

Nadia

Cédric

et al. 2023

Journal of Parasitology Research

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Background. Reduction of oxidative stress during malaria infection is considered as being of great benefit so long as treatment and drug development approaches are concerned. This study had the aim of evaluating the antimalarial and antioxidant activities of the ethanolic extract of Terminalia macroptera in Swiss albino mice infected with the Plasmodium berghei NK65 strain. Methods. In vivo, the antiplasmodial activity of the plant ethanolic extract was tested in a four-day suppressive and curative assay using P. berghei in Swiss albino mice. The extract was administered to the mice at doses of 125, 250, and 500 mg/kg per day. Then, parameters, such as parasite suppression and survival time of the mice, were evaluated. Furthermore, the effect of plant extract on liver damage, oxidative stress indicators, and lipid profile changes in P. berghei-infected mice were studied. Results. Administration of T. macroptera significantly suppressed P. berghei infection by 55.17%, 70.69%, and 71.10% at doses of 125, 250, and 500 mg/kg, respectively, whereas chloroquine had 84.64% suppression relative to the untreated group 1% Dimethyl sulfoxide (1% DMSO) at day 4 (post-infection) in the four-day suppressive test. This suppression activity rate was dose-dependent. The curative test also presented a significant reduction in parasitemia and an extension of the survival time of the treated groups. Treatment of infected parasitized mice with the extract of T. macroptera had a significant ( p < 0.05 ) reduction in parameters, such as total protein, aspartate aminotransferase, and alanine aminotransferase. Infection may also lead to a significant increase in the enzymatic activity of liver catalase and superoxide dismutase compared with the normal control group. The non-enzymatic antioxidant activity in parasitized mice was significantly reduced in malondialdehyde and increased in glutathione and nitric oxide when compared with the normal control group. Conclusions. These findings support the ethnobotanical use of T. macroptera stem bark as an antimalarial remedy coupled with antioxidant activity. However, further in vivo toxicity tests are required to ascertain its safety.

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Section: Methodsmentioning

confidence: 99%

Antimalarial and Antioxidant Activities of Ethanolic Stem Bark Extract of Terminalia macroptera in Swiss Albino Mice Infected with Plasmodium berghei

Sidiki

Nadia

Cédric

et al. 2023

Journal of Parasitology Research

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“…Heligmosomatidae) (Josué et al, 2012) e o extrato aquoso de Palicourea marcgravii A. St.-Hil. Que causou a mortalidade dos ovos da mosca-negra-dos-citros (Aleurocanthus woglumi Ashby (Hemiptera: Aleyrodidae)) (Pena, 2012).…”

Section: Toxicidade Sobre Ovos De P Xylostellaunclassified

Extratos aquosos de Psychotria sp. interferem na biologia de Plutella xylostella

Silva

Fioratti

Faca

et al. 2021

RSD

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Extratos botânicos com propriedades inseticidas buscam minimizar os problemas provocados pelo uso incorreto e muitas vezes exagerado dos agrotóxicos. Dependendo da concentração utilizada e do método de extração, certos extratos podem provocar diversas reações sobre os insetos-daninhos. Sendo assim, o presente trabalho teve por objetivo avaliar a toxicidade dos extratos aquosos elaborados por maceração e infusão de Psychotria capillacea, Psychotria deflexa e Psychotria leiocarpa sobre ovos, larvas e pupas de Plutella xylostella. Foram utilizados sete tratamentos para avaliar a toxicidade dos extratos, sendo: 1) infusão P. capillacea, 2) infusão de P. deflexa, 3) infusão de P. leiocarpa, 4) maceração P. capillacea, 5) maceração de P. deflexa, 6) maceração de P. leiocarpa e 7) água destilada (controle). Larvas de terceiro instar de P. xylostella e pupas com até três dias de formação receberam aplicação tópica dos tratamentos, enquanto fragmentos de couve contendo ovos desse inseto foram imersos nos tratamentos. Os resultados demonstraram que os extratos aquosos por infusão e maceração de P. capillacea e P. leiocarpa e P. deflexa não apresentaram toxicidade significativa sobre as larvas e pupas de P. xylostella, enquanto extratos elaborados por maceração reduziram a sobrevivência de ovos desse inseto. Observou-se que os extratos macerados causaram a mortalidade nas primeiras 46 horas e as infusões foram mais efetivas após esse período. Sendo assim, outros testes devem ser realizados para elucidar a eficiência dos extratos de Psychotria sobre os parâmetros biológicos e comportamentais de P. xylostella, tendo em vista que novas técnicas de extração devem ser exploradas.

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Assessment of Anticoccidial and Antioxidant Efficacy of Methanolic Extract of Pentaclethra macrophylla on Rabbits

Cedric¹,

Payne²,

Ch³

et al. 2018

Research J. of Veterinary Sciences

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In vitroovicidal and larvicidal activities of aqueous and ethanolic extracts of stem bark ofNauclea latifolia(Rubiaceae) onHeligmosomoides bakeri(Nematoda, Heligmosomatidae)

Cited by 3 publications

References 0 publications

Antimalarial and Antioxidant Activities of Ethanolic Stem Bark Extract of Terminalia macroptera in Swiss Albino Mice Infected with Plasmodium berghei

Antimalarial and Antioxidant Activities of Ethanolic Stem Bark Extract of Terminalia macroptera in Swiss Albino Mice Infected with Plasmodium berghei

Extratos aquosos de Psychotria sp. interferem na biologia de Plutella xylostella

Assessment of Anticoccidial and Antioxidant Efficacy of Methanolic Extract of Pentaclethra macrophylla on Rabbits

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