<i>In vitro</i> metabolism of progesterone by canine hair follicle cells

Bamberg, E.; Aichinger, Amanda; Wünsch, Gerda

doi:10.1111/j.1365-3164.2005.00450.x

Cited by 10 publications

(5 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have shown that cortisol can be detected in hair . Skin from humans and dogs is able to produce cortisol. The source of the hormone is not clear, and various possibilities have been considered in the literature (for example see Skobowiat et al .)…”

Section: Discussionmentioning

confidence: 99%

Measurement of cortisol in dog hair: a noninvasive tool for the diagnosis of hypercortisolism

Ouschan

Kuchar

Möstl

2013

Veterinary Dermatology

View full text Add to dashboard Cite

Background -The clinical signs of hyperadrenocorticism (hypercortisolism) in dogs are known to be caused by chronic overexposure to glucocorticoids. The quantification of cortisol in serum, saliva or urine reflects the cortisol concentration at the time of sample collection, but in suspected hyperadrenocorticism it may be preferable to examine a long-term parameter of cortisol production.Hypothesis/Objectives -There is a need for a noninvasive method to monitor the long-term production of cortisol in dogs. It seems possible that measuring cortisol levels in hair could represent such a method.Animals -Hair was collected from 12 dogs with hyperadrenocorticism and from 10 healthy control dogs.Methods -Immunoreactive cortisol, cortisone and corticosterone concentrations were determined by enzyme immunoassay. High-performance liquid chromatography was performed to test the validity of the cortisol assay.Results -Levels of immunoreactive cortisol, cortisone and corticosterone were significantly higher in dogs with hyperadrenocorticism than in control dogs. The difference was most pronounced for the cortisol level.Conclusions and clinical importance -The determination of cortisol in hair offers the advantage that sampling is easier and less invasive than taking blood, urine, faeces or saliva. Measuring cortisol in hair may represent a valuable tool for the diagnosis of hyperadrenocorticism in dogs.

show abstract

Section: Discussionmentioning

confidence: 99%

Measurement of cortisol in dog hair: a noninvasive tool for the diagnosis of hypercortisolism

Ouschan

Kuchar

Möstl

2013

Veterinary Dermatology

View full text Add to dashboard Cite

show abstract

“…Later studies (Keckeis et al 2012;Stubsjoen et al 2015) also suggest a possibility of local production of cortisol and intrafollicular autonomous cortisol synthesis. In addition, canine hair follicle cells in vitro are able to metabolise progesterone to cortisol (Bamberg et al 2005).…”

Section: Stress Hormonesmentioning

confidence: 99%

Analysis of cortisol in dog hair - a potential biomarker of chronic stress: a review

Mesarčová¹,

Kottferová²,

Skurková³

et al. 2017

Vet. Med.

View full text Add to dashboard Cite

Cortisol, which is produced in the adrenal glands, is an endogenous glucocorticoid hormone that delivers its hormonal message to cells by acting on glucocorticoid receptors. It is one of the main stress hormones responsible for stress responses in animals and humans, and its overproduction is characteristic of certain diseases. While acute stress disorder can be evaluated by means of measuring the cortisol concentration in blood and urine, chronic stress disorder can be detected by monitoring the cortisol concentration in fur or hair. Hair collection is simple, inexpensive and non-invasive, and can be performed easily and rapidly; thus, it appears to be a suitable method for determining the level of stress in dogs from shelters, abused dogs or dogs involved in different types of animal interactions. Since it is a relatively new method, monitoring cortisol in hair or fur requires further research in order to definitively prove its efficacy, and possibly to determine reference range values for different breeds of dogs.

show abstract

“…Canine hair follicles have been shown to express sex steroid receptors, 21 and their cells were shown to metabolize sex steroids. 22,23 Human hair follicles have been reported to function both as an estrogen target and as an estrogen source. 24 In conclusion, the findings of the present study support the use of deslorelin as an option for the treatment of intact male dogs with hair cycle arrest.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, given that the pathogenesis of hair cycle arrest is still unclear, either adrenal gland‐derived hormones or other factors related to the hair follicle behaviour might be involved. Canine hair follicles have been shown to express sex steroid receptors, and their cells were shown to metabolize sex steroids . Human hair follicles have been reported to function both as an estrogen target and as an estrogen source …”

Section: Discussionmentioning

confidence: 99%