<i>In vitro</i> inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes

Zhang, Ning; Liu, Jing; Chen, Zhixia; Dou, Wenwen

doi:10.1080/13880209.2019.1656257

Cited by 15 publications

(12 citation statements)

References 33 publications

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“…It also showed potential effects in downregulating the immune system in mice [17]. A study by Zhang [66]. The glycosyloxyflavone apiin was measured at a high concentration (5 µg/L) in a water sample from the Bode catchment but was also obtained in two water samples from ELP at an average concentration of 2.9 µg/L.…”

Section: Distribution Of the Identified Metabolites In River Watersmentioning

confidence: 99%

Non-target screening for detecting the occurrence of plant metabolites in river waters

2020

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Background In surface waters, using liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS), typically large numbers of chemical signals often with high peak intensity remain unidentified. These chemical signals may represent natural compounds released from plants, animals and microorganisms, which may contribute to the cumulative toxic risk. Thus, attempts were made to identify natural compounds in significant concentrations in surface waters by identifying overlapping LC-HRMS peaks between extracts of plants abundant in the catchment and river waters using a non-target screening (NTS) work flow. Results The result revealed the presence of several thousands of overlapping peaks between water—and plants from local vegetation. Taking this overlap as a basis, 12 SPMs from different compound classes were identified to occur in river waters with flavonoids as a dominant group. The concentrations of the identified compounds ranged from 0.02 to 5 µg/L with apiin, hyperoside and guanosine with highest concentrations. Most of the identified compounds exceeded the threshold for toxicological concern (TTC) (0.1 µg/L) for non-genotoxic and non-endocrine disrupting chemicals in drinking water often by more than one order of magnitude. Conclusion Our results revealed the contribution of chemicals eluted from the vegetation in the catchment to the chemical load in surface waters and help to reduce the number of unknowns among NTS high-intensity peaks detected in rivers. Since secondary plant metabolites (SPMs) are often produced for defence against other organisms and since concentrations ranges are clearly above TTC a contribution to toxic risks on aquatic organisms and impacts on drinking water safety cannot be excluded. This demands for including these compounds into monitoring and assessment of water quality.

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Section: Distribution Of the Identified Metabolites In River Watersmentioning

confidence: 99%

Non-target screening for detecting the occurrence of plant metabolites in river waters

2020

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“…It also showed potential effects in downregulating the immune system in mice (Guan et al 2014). A study by Zhang et al showed that kaempferitrin competitively inhibited human liver microsomal Cytochrome P450 1A2 activity at an IC 50 of 11 mg/L in vitro (Zhang et al 2019).…”

Section: Distribution Of the Identi Ed Metabolites In River Watersmentioning

confidence: 99%

Non-target screening for detecting the occurrence of plant metabolites in river waters

Nanusha

Krauß

Brack

2020

Preprint

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Background: In surface waters, using liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS), typically large numbers of chemical signals often with high peak intensity remain unidentified. These chemical signals may represent natural compounds released from plants, animals and microorganisms, which may contribute to the cumulative toxic risk. Thus, attempts were made to identify natural compounds in significant concentrations in surface waters by identifying overlapping LC-HRMS peaks between extracts of plants abundant in the catchment and river waters using a non-target screening (NTS) work flow. Results: The result revealed the presence of several thousands of overlapping peaks between water – and plants from local vegetation. Taking this overlap as a basis, 12 SPMs from different compound classes were identified to occur in river waters with flavonoids as a dominant group. The concentrations of the identified compounds ranged from 0.02 to 5 µg/L with apiin, hyperoside and guanosine with highest concentrations. Most of the identified compounds exceeded the threshold for toxicological concern (TTC) (0.1 µg/L) for non-genotoxic and non-endocrine disrupting chemicals in drinking water often by more than one order of magnitude. Conclusion: Our results revealed the contribution of chemicals eluted from the vegetation in the catchment to the chemical load in surface waters and help to reduce the number of unknowns among NTS high-intensity peaks detected in rivers. Since secondary plant metabolites (SPMs) are often produced for defence against other organisms and since concentrations ranges are clearly above TTC a contribution to toxic risks on aquatic organisms and impacts on drinking water safety cannot be excluded. This demands for including these compounds into monitoring and assessment of water quality.

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“…Nicoti orin was found to protect against memory dysfunction and oxidative stress in multi-infarct dementia model rats (Huang et al 2007;Harborne and Baxter 1999). A study by Zhang et al showed that kaempferitrin competitively inhibited human liver microsomal Cytochrome P450 1A2 activity (Zhang et al 2019).…”

Section: Flavonoidsmentioning

confidence: 99%

Occurrence of Emerging Contaminants of Plant Origin in River Waters from Vejle, Denmark

Nanusha¹,

Krauß²,

Soerensen³

et al. 2020

Preprint

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Background: A large number of chemicals are constantly introduced to surface water from anthropogenic and natural sources. So far, unlike anthropogenic pollutants, naturally occurring compounds are not included in environmental monitoring programs due to limited knowledge on their occurrence and effects in the environment. Since first studies suggest that natural compounds might contribute to mixture risks in aquatic ecosystems and for drinking water production, there is a need to increase empirical evidence on the occurrence of these compounds in aquatic systems. To this end, we performed target screening on 160 toxic secondary plant metabolites (PSMs), prioritized in silico for their likelihood of occurrence, persistence, toxicity and mobility in river waters, using liquid chromatography coupled to high resolution mass spectrometry (LC-HRMS). The samples were collected during rain events from three Danish rivers from an area covered by grassland, forest and agricultural crops. Results: In total, 27 targets belonging to different compound classes such as alkaloids, coumarins and flavonoids were detected, among them 12 compounds, which have not been reported in surface waters before. The most prominent compound class was the group of alkaloids with 41 % of the detected targets, many of them detected in more than 80 % of the samples. Individual compound concentrations were up to several hundred ng/L with the neurotoxic alkaloid coniine from poison hemlock and the flavonoid daidzein reaching highest maximum concentrations. Conclusions: The measured natural toxin concentrations are well within the range of those of synthetic environmental contaminants and need to be considered for the assessment of potential risks on aquatic organisms and drinking water production.

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In vitro inhibitory effects of kaempferitrin on human liver cytochrome P450 enzymes

Cited by 15 publications

References 33 publications

Non-target screening for detecting the occurrence of plant metabolites in river waters

Non-target screening for detecting the occurrence of plant metabolites in river waters

Non-target screening for detecting the occurrence of plant metabolites in river waters

Occurrence of Emerging Contaminants of Plant Origin in River Waters from Vejle, Denmark

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