<i>In Vitro</i> Immunostimulating Activity of the Dried Sap from Fermented Thai Rice on Human and Murine Neutrophils

Manosroi, Aranya; Lohcharoenkal, Warangkana; Ruksiriwanich, Warintorn; Kietthanakorn, Bang-on; Manosroi, Worapaka; Manosroi, Jiradej

doi:10.1166/asl.2012.4265

Cited by 3 publications

(4 citation statements)

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Section: Anti-inflammatory Activitymentioning

confidence: 87%

“…Nevertheless, in earlier research, polysaccharide from this mushroom escalated NO, IL-1β, IL-6, and TNF-α production [13], activated IL-1β, and IL-18 secretion in LPS-induced macrophages [14], and IL-1β, IL-6, and IL-18 were enhanced in colitis mice [43]. Recently published studies reported that the bioactive compounds from various sources could regulate the immune system [39,[44][45][46][47][48]. This result agreed with a previous study, showing that crude polysaccharide from D. indusiata extracts could reduce inflammatory cytokines (IL-1β, IL-6, and TNF-α) in antibiotic-induced intestinal dysbiosis in mice [41].…”

Section: Anti-inflammatory Activitymentioning

confidence: 89%

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High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

Nazir

Linsaenkart

Khantham

et al. 2021

JoF

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Dictyophora indusiata or Phallus indusiatus is widely used as not only traditional medicine, functional foods, but also, skin care agents. Biological activities of the fruiting body from D. indusiata were widely reported, while the studies on the application of immature bamboo mushroom extracts were limited especially in the wound healing effect. Wound healing process composed of 4 stages including hemostasis, inflammation, proliferation, and remodelling. This study divided the egg stage of bamboo mushroom into 3 parts: peel and green mixture (PGW), core (CW), and whole mushroom (WW). Then, aqueous extracts were investigated for their nucleotide sequencing, biological compound contents, and wound healing effect. The anti-inflammatory determination via the levels of cytokine releasing from macrophages, and the collagen stimulation activity on fibroblasts by matrix metalloproteinase-2 (MMP-2) inhibitory activity were determined to serve for the wound healing process promotion in the stage 2–4 (wound inflammation, proliferation, and remodelling of the skin). All D. indusiata extracts showed good antioxidant potential, significantly anti-inflammatory activity in the decreasing of the nitric oxide (NO), interleukin-1 (IL-1), interleukin-1 (IL-6), and tumour necrosis factor-α (TNF-α) secretion from macrophage cells (p < 0.05), and the effective collagen stimulation via MMP-2 inhibition. In particular, CW extract containing high content of catechin (68.761 ± 0.010 mg/g extract) which could significantly suppress NO secretion (0.06 ± 0.02 µmol/L) better than the standard anti-inflammatory drug diclofenac (0.12 ± 0.02 µmol/L) and their MMP-2 inhibition (41.33 ± 9.44%) was comparable to L-ascorbic acid (50.65 ± 2.53%). These findings support that CW of D. indusiata could be an essential natural active ingredient for skin wound healing pharmaceutical products.

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Section: Anti-inflammatory Activitymentioning

confidence: 87%

Section: Anti-inflammatory Activitymentioning

confidence: 89%

High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

Nazir

Linsaenkart

Khantham

et al. 2021

JoF

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“…The DPPH radical scavenging capacity of each extract was carried out according to the previous method [ 74 ] with slight modifications. In brief, 150 μL of freshly prepared DPPH solution (0.1 mM) was mixed with 50 μL of different concentrations of trolox (0.02–0.4 mg/mL) or extract solution in a 96-well plate.…”

Section: Methodsmentioning

confidence: 99%

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

Khantham

Linsaenkart

Chaitep

et al. 2022

Plants

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Androgenetic alopecia (AGA), a hair loss disorder, is a genetic predisposition to sensitive androgens, inflammation, and oxidative stress. Unfortunately, current treatments with synthetic medicines contain a restricted mechanism along with side effects, whereas the bioactive constituents of plant extracts are multifunctional, with fewer side effects. The massive amounts of rice husk and bran are agricultural wastes that may cause pollution and environmental problems. Owing to these rationales, the local rice variety, Bue Bang 3 CMU (BB3CMU), which is grown in northern Thailand, was evaluated for the valuable utilization of rice by-products, husk (BB3CMU-H) and bran (BB3CMU-RB) extracts, for AGA treatment regarding antioxidant, anti-inflammatory, anti-androgenic activities, and the characterization of bioactive compounds. Our study verified that BB3CMU-H had the highest level of polyphenols, contributing to its greater antioxidant activity. Conversely, BB3CMU-RB was the predominant source of tocopherols, resulting in better anti-androgenic activities regarding the downregulation of steroid 5α-reductase genes (SRD5A). Notably, anti-inflammation via the attenuation of nitric oxide productions was observed in BB3CMU-H (0.06 ± 0.13 μM) and BB3CMU-RB (0.13 ± 0.01 μM), which were significantly comparable to diclofenac sodium salt (0.13 ± 0.19 μM). Therefore, the combination of BB3CMU-H and BB3CMU-RB could be utilized in cosmeceutical and pharmaceutical applications for AGA patients.

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“…Individual fatty acids were quantified in terms of g/100 g of extract. The DPPH radical scavenging capacity of the extract was measured using the previous method [24]. In a 96-well plate, 0.1 mM DPPH solution was mixed with trolox (0.02-0.4 mg/mL) or extract solution.…”

Section: Determination Of Free Fatty Acidsmentioning

confidence: 99%

Effects of Bioactive Composition in Oryza sativa L. cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells

et al. 2023

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The aim of this study is to identify the effects of KDML105 bran extract on gene expression involving the hair cycle in HFDPCs and investigate its bioactive constituents, antioxidant, and anti-inflammatory activities. The content of tocopherols, γ-oryzanol, phytic acid, and phenolic compounds was quantified by liquid chromatography. Free fatty acids were determined using gas chromatography. Antioxidant capacities were estimated by DPPH, ABTS, and metal chelating assay. The nitric oxide (NO) production was determined by Griess reaction. Gene expression was measured by semi-quantitative RT-PCR. The major compounds in the extract were α- and γ-tocopherol, phytic acid, γ-oryzanol, chlorogenic acid, o-coumaric acid, palmitic acid, oleic acid, and linoleic acid, giving its antioxidant capacities. The nitrite level in lipopolysaccharide-induced macrophages (2.76 ± 0.13 μM) was significantly mitigated by the extract (0.81 ± 0.11 μM). Additionally, SRD5A2 and TGFB1 expressions in HFDPCs were downregulated, whereas CTNNB1 and VEGF genes were upregulated after treatment with the extract. KDML105 extract ameliorated oxidative stress and NO production. According to the gene expression study, KDML105 bran extract may be involved in the induction and maintenance of the anagen phase and angiogenesis in the hair growth pathway. Therefore, KDML105 bran extract might be a promising source of anti-hair loss substances.

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In Vitro Immunostimulating Activity of the Dried Sap from Fermented Thai Rice on Human and Murine Neutrophils

Cited by 3 publications

References 0 publications

High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

Effects of Bioactive Composition in Oryza sativa L. cv. KDML105 Bran Extract on Gene Expression Related to Hair Cycle in Human Hair Follicle Dermal Papilla Cells

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